Search Results - "Randell, H."

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo by Hou, Yixuan J, Chiba, Shiho, Halfmann, Peter, Ehre, Camille, Kuroda, Makoto, Dinnon, 3rd, Kenneth H, Leist, Sarah R, Schäfer, Alexandra, Nakajima, Noriko, Takahashi, Kenta, Lee, Rhianna E, Mascenik, Teresa M, Graham, Rachel, Edwards, Caitlin E, Tse, Longping V, Okuda, Kenichi, Markmann, Alena J, Bartelt, Luther, de Silva, Aravinda, Margolis, David M, Boucher, Richard C, Randell, Scott H, Suzuki, Tadaki, Gralinski, Lisa E, Kawaoka, Yoshihiro, Baric, Ralph S

“…The spike aspartic acid-614 to glycine (D614G) substitution is prevalent in global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but…”
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Human nasal and tracheo-bronchial respiratory epithelial cell culture by Fulcher, M Leslie, Randell, Scott H

“…Human airway epithelial (hAE) cell cultures are instrumental for studying basic and applied aspects of respiratory tract biology, disease, and therapy. When…”
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Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function by Hogan, Brigid L.M., Barkauskas, Christina E., Chapman, Harold A., Epstein, Jonathan A., Jain, Rajan, Hsia, Connie C.W., Niklason, Laura, Calle, Elizabeth, Le, Andrew, Randell, Scott H., Rock, Jason, Snitow, Melinda, Krummel, Matthew, Stripp, Barry R., Vu, Thiennu, White, Eric S., Whitsett, Jeffrey A., Morrisey, Edward E.

“…Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have…”
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Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways by Okuda, Kenichi, Chen, Gang, Subramani, Durai B, Wolf, Monroe, Gilmore, Rodney C, Kato, Takafumi, Radicioni, Giorgia, Kesimer, Mehmet, Chua, Michael, Dang, Hong, Livraghi-Butrico, Alessandra, Ehre, Camille, Doerschuk, Claire M, Randell, Scott H, Matsui, Hirotoshi, Nagase, Takahide, O'Neal, Wanda K, Boucher, Richard C

“…MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus layer of human airways. Each mucin has distinct functions and site-specific expression…”
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A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence by Menachery, Vineet D, Yount, Boyd L, Debbink, Kari, Agnihothram, Sudhakar, Gralinski, Lisa E, Plante, Jessica A, Graham, Rachel L, Scobey, Trevor, Ge, Xing-Yi, Donaldson, Eric F, Randell, Scott H, Lanzavecchia, Antonio, Marasco, Wayne A, Shi, Zhengli-Li, Baric, Ralph S

“…Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect…”
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Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection by Menachery, Vineet D, Dinnon, 3rd, Kenneth H, Yount, Jr, Boyd L, McAnarney, Eileen T, Gralinski, Lisa E, Hale, Andrew, Graham, Rachel L, Scobey, Trevor, Anthony, Simon J, Wang, Lingshu, Graham, Barney, Randell, Scott H, Lipkin, W Ian, Baric, Ralph S

“…Traditionally, the emergence of coronaviruses (CoVs) has been attributed to a gain in receptor binding in a new host. Our previous work with severe acute…”
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IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells by Tadokoro, Tomomi, Wang, Yang, Barak, Larry S., Bai, Yushi, Randell, Scott H., Hogan, Brigid L. M.

“…The pseudostratified airway epithelium of the lung contains a balanced proportion of multiciliated and secretory luminal cells that are maintained and…”
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SARS-like WIV1-CoV poised for human emergence by Menachery, Vineet D., Yount, Boyd L., Sims, Amy C., Debbink, Kari, Agnihothram, Sudhakar S., Gralinski, Lisa E., Graham, Rachel L., Scobey, Trevor, Plante, Jessica A., Royal, Scott R., Swanstrom, Jesica, Sheahan, Timothy P., Pickles, Raymond J., Corti, Davide, Randell, Scott H., Lanzavecchia, Antonio, Marasco, Wayne A., Baric, Ralph S.

“…Outbreaks from zoonotic sources represent a threat to both human disease as well as the global economy. Despite a wealth of metagenomics studies,methods to…”
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Chronic E-Cigarette Exposure Alters the Human Bronchial Epithelial Proteome by Ghosh, Arunava, Coakley, Raymond C, Mascenik, Teresa, Rowell, Temperance R, Davis, Eric S, Rogers, Keith, Webster, Megan J, Dang, Hong, Herring, Laura E, Sassano, M Flori, Livraghi-Butrico, Alessandra, Van Buren, Scott K, Graves, Lee M, Herman, Melissa A, Randell, Scott H, Alexis, Neil E, Tarran, Robert

“…E-cigarettes vaporize propylene glycol/vegetable glycerin (PG/VG), nicotine, and flavorings. However, the long-term health effects of exposing lungs to vaped…”
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Pharmacological Rescue of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells by Gentzsch, Martina, Boyles, Susan E, Cheluvaraju, Chaitra, Chaudhry, Imron G, Quinney, Nancy L, Cho, Crescentia, Dang, Hong, Liu, Xuefeng, Schlegel, Richard, Randell, Scott H

“…Well-differentiated primary human bronchial epithelial (HBE) cell cultures are vital for cystic fibrosis (CF) research, particularly for the development of…”
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Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection by Edwards, Caitlin E., Yount, Boyd L., Graham, Rachel L., Leist, Sarah R., Hou, Yixuan J., Dinnon, Kenneth H., Sims, Amy C., Swanstrom, Jesica, Gully, Kendra, Scobey, Trevor D., Cooley, Michelle R., Currie, Caroline G., Randell, Scott H., Baric, Ralph S.

“…Zoonotic coronaviruses represent an ongoing threat, yet the myriads of circulating animal viruses complicate the identification of higher-risk isolates that…”
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Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens by Liu, Xuefeng, Krawczyk, Ewa, Suprynowicz, Frank A, Palechor-Ceron, Nancy, Yuan, Hang, Dakic, Aleksandra, Simic, Vera, Zheng, Yun-Ling, Sripadhan, Praathibha, Chen, Chen, Lu, Jie, Hou, Tung-Wei, Choudhury, Sujata, Kallakury, Bhaskar, Tang, Dean G, Darling, Thomas, Thangapazham, Rajesh, Timofeeva, Olga, Dritschilo, Anatoly, Randell, Scott H, Albanese, Christopher, Agarwal, Seema, Schlegel, Richard

“…This protocol demonstrates how to establish primary epithelial cell cultures in vitro from healthy human tissue and human cancer samples using ROCK inhibitor…”
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Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells by Hawkins, Finn J., Suzuki, Shingo, Beermann, Mary Lou, Barillà, Cristina, Wang, Ruobing, Villacorta-Martin, Carlos, Berical, Andrew, Jean, J.C., Le Suer, Jake, Matte, Taylor, Simone-Roach, Chantelle, Tang, Yang, Schlaeger, Thorsten M., Crane, Ana M., Matthias, Nadine, Huang, Sarah X.L., Randell, Scott H., Wu, Joshua, Spence, Jason R., Carraro, Gianni, Stripp, Barry R., Rab, Andras, Sorsher, Eric J., Horani, Amjad, Brody, Steven L., Davis, Brian R., Kotton, Darrell N.

“…The derivation of tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would have broad reaching implications for regenerative…”
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GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells by Gao, Xia, Bali, Aman S, Randell, Scott H, Hogan, Brigid L M

“…Pseudostratified airway epithelium of the lung is composed of polarized ciliated and secretory cells maintained by basal stem/progenitor cells. An important…”
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Basal cells as stem cells of the mouse trachea and human airway epithelium by Rock, Jason R, Onaitis, Mark W, Rawlins, Emma L, Lu, Yun, Clark, Cheryl P, Xue, Yan, Randell, Scott H, Hogan, Brigid L.M

“…The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5)…”
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Terminal N-Linked Galactose Is the Primary Receptor for Adeno-associated Virus 9 by Shen, Shen, Bryant, Kelli D., Brown, Sarah M., Randell, Scott H., Asokan, Aravind

“…Sialylated glycans serve as cell surface attachment factors for a broad range of pathogens. We report an atypical example, where desialylation increases cell…”
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Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis by Berical, Andrew, Lee, Rhianna E, Randell, Scott H, Hawkins, Finn

“…Mutations in the cystic fibrosis transmembrane conductance regulator ( ) gene cause the life-limiting hereditary disease, cystic fibrosis (CF). Decreased or…”
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A biomimetic multicellular model of the airways using primary human cells by Sellgren, Katelyn L, Butala, Elizabeth J, Gilmour, Brian P, Randell, Scott H, Grego, Sonia

“…Microfluidic cell cultures enable investigation of complex physiological tissue properties and functionalities. For convenience, they are often implemented…”
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Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus by Scobey, Trevor, Yount, Boyd L., Sims, Amy C., Donaldson, Eric F., Agnihothram, Sudhakar S., Menachery, Vineet D., Graham, Rachel L., Swanstrom, Jesica, Bove, Peter F., Kim, Jeeho D., Grego, Sonia, Randell, Scott H., Baric, Ralph S.

“…Severe acute respiratory syndrome with high mortality rates (∼50%) is associated with a novel group 2c betacoronavirus designated Middle East respiratory…”
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Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells by Suprynowicz, Frank A, Upadhyay, Geeta, Krawczyk, Ewa, Kramer, Sarah C, Hebert, Jess D, Liu, Xuefeng, Yuan, Hang, Cheluvaraju, Chaitra, Clapp, Phillip W, Boucher, Richard C, Kamonjoh, Christopher M, Randell, Scott H, Schlegel, Richard

“…The combination of irradiated fibroblast feeder cells and Rho kinase inhibitor, Y-27632, conditionally induces an indefinite proliferative state in primary…”
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