Search Results - "Randazzo, Pietro"
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Psychological distress and quality of life are improved in autoimmune patients through Tandem-Psychotherapy, combining individual hypnosis and eye movement desensitization and reprocessing (EMDR) treatment for trauma, followed by supportive-expressive group therapy
Published in Clinical rheumatology (01-04-2020)“…Objective Autoimmune diseases are associated with psychological distress, resulting in greatly impaired quality of life. Tandem-Psychotherapy comprises…”
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Squalene-Based Nano-Assemblies Improve the Pro-Autophagic Activity of Trehalose
Published in Pharmaceutics (14-04-2022)“…The disaccharide trehalose is a well-established autophagy inducer, but its therapeutic application is severely hampered by its low potency and poor…”
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Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers
Published in Pharmaceutics (20-08-2019)“…The disaccharide trehalose is an autophagy inducer, but its pharmacological application is severely limited by its poor pharmacokinetics properties. Thus,…”
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IncobotulinumtoxinA Injection for Treating Children with Idiopathic Toe Walking: A Retrospective Efficacy and Safety Study
Published in Toxins (13-11-2022)“…There is no gold-standard treatment for idiopathic toe walking (ITW). Some previous evidence suggested that botulinum neurotoxin-A injection might improve ITW…”
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Identification and in vitro characterization of a new series of potent and highly selective G9a inhibitors as novel anti-fibroadipogenic agents
Published in Bioorganic & medicinal chemistry letters (15-09-2022)“…[Display omitted] A new series of in vitro potent and highly selective histone methyl transferase enzyme G9a inhibitors was obtained. In particular, compound…”
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Synthesis and Characterization of Novel Mono- and Bis-Guanyl Hydrazones as Potent and Selective ASIC1 Inhibitors Able to Reduce Brain Ischemic Insult
Published in Journal of medicinal chemistry (24-06-2021)“…Acid-sensitive ion channels (ASICs) are sodium channels partially permeable to Ca2+ ions, listed among putative targets in central nervous system (CNS)…”
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Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators
Published in Bioorganic & medicinal chemistry letters (01-10-2022)“…[Display omitted] Chronic hepatitis B (CHB) is a major worldwide public health problem and novel anti-HBV therapies preventing liver disease progression to…”
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Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors
Published in ACS medicinal chemistry letters (11-05-2023)“…Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is the first reported nonreceptor oncogenic tyrosine phosphatase connecting multiple signal…”
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Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS
Published in ACS medicinal chemistry letters (11-04-2019)“…Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in…”
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