Search Results - "Randazzo, James"

A T-dependent antibody response evaluation in CD-1 mice after an acute whole-body inhalation exposure to nickel (II) chloride hexahydrate by Buxton, Samuel, Taylor, Michael D., Weinberg, Jeffrey T., Randazzo, James M., Peachee, Vanessa L., Oller, Adriana

“…Nickel (Ni) in ambient air may vary regionally with contributions from both natural processes and anthropogenic activities. Exposure to Ni compounds in ambient…”
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Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats by Randazzo, James, Zhang, Peng, Makita, Jun, Blessing, Karen, Kador, Peter F

“…Age-related cataract is a worldwide health care problem whose progression has been linked to oxidative stress and the accumulation of redox-active metals…”
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Orally active multi-functional antioxidants are neuroprotective in a rat model of light-induced retinal damage by Randazzo, James, Zhang, Zifeng, Hoff, Michael, Kawada, Hiroyoshi, Sachs, Andrew, Yuan, Yang, Haider, Neena, Kador, Peter

“…Progression of age-related macular degeneration has been linked to iron dysregulation and oxidative stress that induce apoptosis of neural retinal cells. Since…”
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Novel diabetic mouse models as tools for investigating diabetic retinopathy by Kador, Peter F, Zhang, Peng, Makita, Jun, Zhang, Zifeng, Guo, Changmei, Randazzo, James, Kawada, Hiroyoshi, Haider, Neena, Blessing, Karen

“…Mouse models possessing green fluorescent protein (GFP) and/or human aldose reductase (hAR) in vascular tissues have been established and crossed with…”
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Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB) by Kador, Peter F, Randazzo, James, Blessing, Karen, Makita, Jun, Zhang, Peng, Yu, Kuang, Hosoya, Ken-Ichi, Terasaki, T

“…The two most widely investigated animal models for diabetic retinopathy (DR) are the rat and dog. In dogs, aldose reductase (AR) is present only in retinal…”
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Elevated Levels of DNA Strand Breaks Induced by a Base Analog in the Human Cell Line with the P32T ITPA Variant by Waisertreiger, Irina S.-R., Menezes, Miriam R., Randazzo, James, Pavlov, Youri I.

“…Base analogs are powerful antimetabolites and dangerous mutagens generated endogenously by oxidative stress, inflammation, and aberrant nucleotide…”
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Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts by Kador, Peter F, Randazzo, James, Babb, Thomas, Koushik, Kavitha, Takamura, Yoshihiro, Zhu, Wenjun, Blessing, Karen, Kompella, Uday B

“…In the topical delivery of drugs to the lens, drug retention on the eye surface is considered to be important because increased retention on the ocular surface…”
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Evaluation of mixtures of flavor chemicals in a 90-day nose-only exposures in sprague-dawley rats by Oldham, Michael J, Desai, Rahat Wadhwa, Randazzo, James, Walling, Brent E, Lalonde, Guy, Weil, Roxana

“…One of the challenges to using some flavor chemicals in aerosol products is the lack of route of administration specific toxicology data. Flavor chemicals (88)…”
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Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation by Zhang, Peng, Xing, Kuiyi, Randazzo, James, Blessing, Karen, Lou, Marjorie F., Kador, Peter F.

“…In sugar cataract formation in rats, aldose reductase (AR) activity is not only linked to lenticular sorbitol (diabetic) or galactitol (galactosemic) formation…”
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Multifunctional Antioxidants for the Treatment of Age-Related Diseases by Jin, Hongxia, Randazzo, James, Zhang, Peng, Kador, Peter F

“…Analogues of N,N-dimethyl-4-(pyrimidin-2-yl)piperazine-1-sulfonamide possessing a free radical scavenger group (FRS), chelating groups (CHL), or both (FRS +…”
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Topical nutraceutical Optixcare EH ameliorates experimental ocular oxidative stress in rats by Kador, Peter F, Guo, Changmei, Kawada, Hiroyoshi, Randazzo, James, Blessing, Karen

“…Based on the hypothesis that oral nutraceuticals do not adequately reach all ocular tissues in the anterior segment, we evaluated the ability of a 3%…”
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Orally Active Multi-Functional Antioxidants Delay Cataract Formation in Streptozotocin by Randazzo, James, Zhang, Peng, Makita, Jun, Blessing, Karen, Kador, Peter F

“…Background Age-related cataract is a worldwide health care problem whose progression has been linked to oxidative stress and the accumulation of redox-active…”
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Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats by Mulhern, Michael L, Madson, Christian J, Kador, Peter F, Randazzo, James, Shinohara, Toshimichi

“…Many cataractogenic stresses also induce endoplasmic reticulum (ER) stress in lens epithelial cells (LECs), which appears to be one of the universal inducers…”
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Evaluation of the vascular targeting agent combretastatin a-4 prodrug on retinal neovascularization in the galactose-fed dog by Kador, Peter F, Blessing, Karen, Randazzo, James, Makita, Jun, Wyman, Milton

“…Combretastatin A-4 (CA-4) is a vascular targeting agent known to rapidly shut off blood flow in new vessels and, as a result, regress neovascularization. In…”
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Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose by Kador, P.F, Betts, D, Wyman, M, Blessing, K, Randazzo, J

“…To determine effects of a topical formulation of an aldose reductase inhibitor (ARI) on the development of sugar cataracts in dogs fed a diet high in…”
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Development of multi-functional antioxidants for use in cataract and age-related macular degeneration by Randazzo, James Michael

“…Oxidative stress induced by free radicals, including reactive oxygen species (ROS), results from the age-related decrease of antioxidant defenses, accumulation…”
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Age-dependent retinal capillary pericyte degeneration in galactose-fed dogs by Kador, Peter F, Takahashi, Yukio, Akagi, Yoshio, Blessing, Karen, Randazzo, James, Wyman, Milton

“…The galactose-fed beagle develops diabetes-like microvascular changes that are histologically and clinically similar in appearance to all stages of human…”
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Development of multi-functional antioxidants for use in cataract and age-related macular degeneration by Randazzo, James Michael

“…Oxidative stress induced by free radicals, including reactive oxygen species (ROS), results from the age-related decrease of antioxidant defenses, accumulation…”
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High-risk screening treatment of juvenile sex offenders by Randazzo, Joseph James

“…Research on juvenile sex offenders is still in its infancy. Strong correlations have already been drawn between sexually assaultive behavior by this population…”
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