Search Results - "Randall T. Moon"

A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development by Paige, Sharon L., Thomas, Sean, Stoick-Cooper, Cristi L., Wang, Hao, Maves, Lisa, Sandstrom, Richard, Pabon, Lil, Reinecke, Hans, Pratt, Gabriel, Keller, Gordon, Moon, Randall T., Stamatoyannopoulos, John, Murry, Charles E.

“…Directed differentiation of human embryonic stem cells (ESCs) into cardiovascular cells provides a model for studying molecular mechanisms of human…”
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Porous Implants Modulate Healing and Induce Shifts in Local Macrophage Polarization in the Foreign Body Reaction by Sussman, Eric M., Halpin, Michelle C., Muster, Jeanot, Moon, Randall T., Ratner, Buddy D.

“…The foreign body reaction (FBR) to implanted materials is of critical importance when medical devices require biological integration and vascularization to…”
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Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency by Mathieu, Julie, Zhou, Wenyu, Xing, Yalan, Sperber, Henrik, Ferreccio, Amy, Agoston, Zsuzsa, Kuppusamy, Kavitha T., Moon, Randall T., Ruohola-Baker, Hannele

“…Pluripotent stem cells have distinct metabolic requirements, and reprogramming cells to pluripotency requires a shift from oxidative to glycolytic metabolism…”
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High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping by Czerniecki, Stefan M., Cruz, Nelly M., Harder, Jennifer L., Menon, Rajasree, Annis, James, Otto, Edgar A., Gulieva, Ramila E., Islas, Laura V., Kim, Yong Kyun, Tran, Linh M., Martins, Timothy J., Pippin, Jeffrey W., Fu, Hongxia, Kretzler, Matthias, Shankland, Stuart J., Himmelfarb, Jonathan, Moon, Randall T., Paragas, Neal, Freedman, Benjamin S.

“…Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid…”
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Macrophages modulate adult zebrafish tail fin regeneration by Petrie, Timothy A, Strand, Nicholas S, Yang, Chao-Tsung, Tsung-Yang, Chao, Rabinowitz, Jeremy S, Moon, Randall T

“…Neutrophils and macrophages, as key mediators of inflammation, have defined functionally important roles in mammalian tissue repair. Although recent evidence…”
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The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition by Sperber, Henrik, Mathieu, Julie, Wang, Yuliang, Ferreccio, Amy, Hesson, Jennifer, Xu, Zhuojin, Fischer, Karin A., Devi, Arikketh, Detraux, Damien, Gu, Haiwei, Battle, Stephanie L., Showalter, Megan, Valensisi, Cristina, Bielas, Jason H., Ericson, Nolan G., Margaretha, Lilyana, Robitaille, Aaron M., Margineantu, Daciana, Fiehn, Oliver, Hockenbery, David, Blau, C. Anthony, Raftery, Daniel, Margolin, Adam A., Hawkins, R. David, Moon, Randall T., Ware, Carol B., Ruohola-Baker, Hannele

“…For nearly a century developmental biologists have recognized that cells from embryos can differ in their potential to differentiate into distinct cell types…”
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Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4 by Davidson, Kathryn C, Adams, Allison M, Goodson, Jamie M, McDonald, Circe E, Potter, Jennifer C, Berndt, Jason D, Biechele, Travis L, Taylor, Russell J, Moon, Randall T

“…Signal transduction pathways play diverse, context-dependent roles in vertebrate development. In studies of human embryonic stem cells (hESCs), conflicting…”
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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery by Moon, Randall T, Zheng, Ning, Yi, Xianhua, Angers, Stephane, MacCoss, Michael J, Li, Ti

“…Protein ubiquitination is a common form of post-translational modification that regulates a broad spectrum of protein substrates in diverse cellular pathways…”
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A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models by Dai, Xuezhi, James, Richard G, Habib, Tania, Singh, Swati, Jackson, Shaun, Khim, Socheath, Moon, Randall T, Liggitt, Denny, Wolf-Yadlin, Alejandro, Buckner, Jane H, Rawlings, David J

“…Multiple autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, Graves disease, and systemic lupus erythematosus, are associated with an allelic…”
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Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine by Stoick-Cooper, Cristi L, Moon, Randall T, Weidinger, Gilbert

“…While all animals have evolved strategies to respond to injury and disease, their ability to functionally recover from loss of or damage to organs or…”
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Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish by Rabinowitz, Jeremy S., Robitaille, Aaron M., Wang, Yuliang, Ray, Catherine A., Thummel, Ryan, Gu, Haiwei, Djukovic, Danijel, Raftery, Daniel, Berndt, Jason D., Moon, Randall T.

“…Regeneration requires cells to regulate proliferation and patterning according to their spatial position. Positional memory is a property that enables…”
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Wnt5a and Wnt11 are essential for second heart field progenitor development by Cohen, Ethan David, Miller, Mayumi F, Wang, Zichao, Moon, Randall T, Morrisey, Edward E

“…Wnt/β-catenin has a biphasic effect on cardiogenesis, promoting the induction of cardiac progenitors but later inhibiting their differentiation. Second heart…”
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LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1 by Ren, Shuyu, Johnson, Bryce G., Kida, Yujiro, Ip, Colin, Davidson, Kathryn C., Lin, Shuei-Liong, Kobayashi, Akio, Lang, Richard A., Hadjantonakis, Anna-Katerina, Moon, Randall T., Duffield, Jeremy S.

“…Fibrosis of vital organs is a major public health problem with limited therapeutic options. Mesenchymal cells including microvascular mural cells (pericytes)…”
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Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration by Goessling, Wolfram, North, Trista E., Loewer, Sabine, Lord, Allegra M., Lee, Sang, Stoick-Cooper, Cristi L., Weidinger, Gilbert, Puder, Mark, Daley, George Q., Moon, Randall T., Zon, Leonard I.

“…Interactions between developmental signaling pathways govern the formation and function of stem cells. Prostaglandin (PG) E2 regulates vertebrate hematopoietic…”
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Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling by Hofsteen, Peter, Robitaille, Aaron M., Chapman, Daniel Patrick, Moon, Randall T., Murry, Charles E.

“…To reveal the molecular mechanisms involved in cardiac lineage determination and differentiation, we quantified the proteome of human embryonic stem cells…”
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Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells by Ueno, Shuichi, Weidinger, Gilbert, Osugi, Tomoaki, Kohn, Aimee D, Golob, Jonathan L, Pabon, Lil, Reinecke, Hans, Moon, Randall T, Murry, Charles E

“…Understanding pathways controlling cardiac development may offer insights that are useful for stem cell-based cardiac repair. Developmental studies indicate…”
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Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment by Morrone, Seamus, Cheng, Zhihong, Moon, Randall T, Cong, Feng, Xu, Wenqing

“…Axin is a tumor suppressor and a key negative regulator of the Wnt/β-catenin signaling pathway. Axin turnover is controlled by its poly-ADP-ribosylation…”
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Distinct Wnt signaling pathways have opposing roles in appendage regeneration by Stoick-Cooper, Cristi L, Weidinger, Gilbert, Riehle, Kimberly J, Hubbert, Charlotte, Major, Michael B, Fausto, Nelson, Moon, Randall T

“…In contrast to mammals, lower vertebrates have a remarkable capacity to regenerate complex structures damaged by injury or disease. This process, termed…”
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Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells by Hadland, Brandon K, Varnum-Finney, Barbara, Poulos, Michael G, Moon, Randall T, Butler, Jason M, Rafii, Shahin, Bernstein, Irwin D

“…Hematopoietic stem cells (HSCs) first emerge during embryonic development within vessels such as the dorsal aorta of the aorta-gonad-mesonephros (AGM) region,…”
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USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds by Madan, Babita, Walker, Matthew P., Young, Robert, Quick, Laura, Orgel, Kelly A., Ryan, Meagan, Gupta, Priti, Henrich, Ian C., Ferrer, Marc, Marine, Shane, Roberts, Brian S., Arthur, William T., Berndt, Jason D., Oliveira, Andre M., Moon, Randall T., Virshup, David M., Chou, Margaret M., Major, Michael B.

“…The Wnt signaling pathways play pivotal roles in carcinogenesis. Modulation of the cell-surface abundance of Wnt receptors is emerging as an important…”
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