Search Results - "Randall, Troy"

Immunological Functions of the Omentum by Meza-Perez, Selene, Randall, Troy D

“…The omentum is a visceral adipose tissue with unique immune functions. Although it is primarily an adipose tissue, the omentum also contains lymphoid…”
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Bronchus-associated lymphoid tissue (BALT) structure and function by Randall, Troy D

“…Bronchus-associated lymphoid tissue (BALT) is a constitutive mucosal lymphoid tissue adjacent to major airways in some mammalian species, including rats and…”
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Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation by Ballesteros-Tato, André, León, Beatriz, Graf, Beth A., Moquin, Amy, Adams, Pamela Scott, Lund, Frances E., Randall, Troy D.

“…T follicular helper (Tfh) cells promote T cell-dependent humoral immune responses by providing T cell help to B cells and by promoting germinal center (GC)…”
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The establishment of resident memory B cells in the lung requires local antigen encounter by Allie, S. Rameeza, Bradley, John E., Mudunuru, Uma, Schultz, Michael D., Graf, Beth A., Lund, Frances E., Randall, Troy D.

“…Memory B cells are found in lymphoid and non-lymphoid tissues, suggesting that some may be tissue-resident cells. Here we show that pulmonary influenza…”
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Effector and regulatory B cells: modulators of CD4 + T cell immunity by Lund, Frances E, Randall, Troy D

“…Key Points Clinical trial data have revealed that B cell depletion can be an effective therapy for a number of autoimmune diseases that are typically thought…”
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Spiking SARS-CoV-2 antiviral immunity in the respiratory tract by Silva-Sanchez, Aaron, Randall, Troy D.

“…The COVID-19 pandemic enabled the successful launch of mRNA-based vaccines that, when given intramuscularly, elicit spike-specific antibodies and prevent…”
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Specialized immune responses in the peritoneal cavity and omentum by Liu, Mingyong, Silva‐Sanchez, Aaron, Randall, Troy D., Meza‐Perez, Selene

“…The peritoneal cavity is a fluid filled space that holds most of the abdominal organs, including the omentum, a visceral adipose tissue that contains milky…”
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Pulmonary immunity to viruses by Allie, S Rameeza, Randall, Troy D

“…Mucosal surfaces, such as the respiratory epithelium, are directly exposed to the external environment and therefore, are highly susceptible to viral…”
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Inducible Bronchus-Associated Lymphoid Tissue: Taming Inflammation in the Lung by Hwang, Ji Young, Randall, Troy D, Silva-Sanchez, Aaron

“…Following pulmonary inflammation, leukocytes that infiltrate the lung often assemble into structures known as inducible Bronchus-Associated Lymphoid Tissue…”
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Immunity in adipose tissues: Cutting through the fat by Randall, Troy D., Meza‐Perez, Selene

“…Summary Well known functions of adipose tissue include energy storage, regulation of thermogenesis, and glucose homeostasis—each of which are associated with…”
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Resident Memory B Cells by Allie, S Rameeza, Randall, Troy D

“…In mammals, adaptive immunity is mediated by a broadly diverse repertoire of naive B and T lymphocytes that recirculate between secondary lymphoid organs…”
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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection by Botta, Davide, Fuller, Michael J, Marquez-Lago, Tatiana T, Bachus, Holly, Bradley, John E, Weinmann, Amy S, Zajac, Allan J, Randall, Troy D, Lund, Frances E, León, Beatriz, Ballesteros-Tato, André

“…Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is…”
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T Follicular Helper Cell Plasticity Shapes Pathogenic T Helper 2 Cell-Mediated Immunity to Inhaled House Dust Mite by Ballesteros-Tato, André, Randall, Troy D., Lund, Frances E., Spolski, Rosanne, Leonard, Warren J., León, Beatriz

“…Exposure to environmental antigens, such as house dust mite (HDM), often leads to T helper 2 (Th2) cell-driven allergic responses. However, the mechanisms…”
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Role of iBALT in Respiratory Immunity by Silva-Sanchez, Aaron, Randall, Troy D

“…Pulmonary respiration inevitably exposes the mucosal surface of the lung to potentially noxious stimuli, including pathogens, allergens, and particulates, each…”
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FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability by León, Beatriz, Bradley, John E., Lund, Frances E., Randall, Troy D., Ballesteros-Tato, André

“…Here, we test the role of FoxP3 + regulatory T cells (Tregs) in controlling T follicular helper (Tfh) and germinal centre (GC) B-cell responses to influenza…”
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Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion by Nguyen, Doan C., Garimalla, Swetha, Xiao, Haopeng, Kyu, Shuya, Albizua, Igor, Galipeau, Jacques, Chiang, Kuang-Yueh, Waller, Edmund K., Wu, Ronghu, Gibson, Greg, Roberson, James, Lund, Frances E., Randall, Troy D., Sanz, Iñaki, Lee, F. Eun-Hyung

“…Human antibody-secreting cells (ASC) in peripheral blood are found after vaccination or infection but rapidly apoptose unless they migrate to the bone marrow…”
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Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy by Mattapally, Saidulu, Pawlik, Kevin M, Fast, Vladimir G, Zumaquero, Esther, Lund, Frances E, Randall, Troy D, Townes, Tim M, Zhang, Jianyi

“…Background We aim to generate a line of "universal donor" human induced pluripotent stem cells (hi PSC s) that are nonimmunogenic and, therefore, can be used…”
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Development of secondary lymphoid organs by Randall, Troy D, Carragher, Damian M, Rangel-Moreno, Javier

“…Secondary lymphoid organs develop during embryogenesis or in the first few weeks after birth according to a highly coordinated series of interactions between…”
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IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs by Barone, Francesca, Nayar, Saba, Campos, Joana, Cloake, Thomas, Withers, David R., Toellner, Kai-Michael, Zhang, Yang, Fouser, Lynette, Fisher, Benjamin, Bowman, Simon, Rangel-Moreno, Javier, de la Luz Garcia-Hernandez, Maria, Randall, Troy D., Lucchesi, Davide, Bombardieri, Michele, Pitzalis, Costantino, Luther, Sanjiv A., Buckley, Christopher D.

“…The series of events leading to tertiary lymphoid organ (TLO) formation in mucosal organs following tissue damage remain unclear. Using a virus-induced model…”
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Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow by Halliley, Jessica L, Tipton, Christopher M, Liesveld, Jane, Rosenberg, Alexander F, Darce, Jaime, Gregoretti, Ivan V, Popova, Lana, Kaminiski, Denise, Fucile, Christopher F, Albizua, Igor, Kyu, Shuya, Chiang, Kuang-Yueh, Bradley, Kyle T, Burack, Richard, Slifka, Mark, Hammarlund, Erika, Wu, Hao, Zhao, Liping, Walsh, Edward E, Falsey, Ann R, Randall, Troy D, Cheung, Wan Cheung, Sanz, Iñaki, Lee, F Eun-Hyung

“…Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans…”
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