Search Results - "Randall, P K"

An examination of the decline in fear and disgust during exposure-based treatment by Smits, J.A.J, Telch, M.J, Randall, P.K

“…It has been suggested that disgust plays a prominent role in the fear of spiders. Participants ( N=27) displaying marked spider fear were provided 30 min of…”
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Effects of brain‐derived neurotrophic factor on dopaminergic function and motor behavior during aging by Boger, H. A., Mannangatti, P., Samuvel, D. J., Saylor, A. J., Bender, T. S., McGinty, J. F., Fortress, A. M., Zaman, V., Huang, P., Middaugh, L. D., Randall, P. K., Jayanthi, L. D., Rohrer, B., Helke, K. L., Granholm, A.‐C., Ramamoorthy, S.

“…Brain‐derived neurotrophic factor (BDNF) is critical in synaptic plasticity and in the survival and function of midbrain dopamine neurons. In this study, we…”
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Intravenous cocaine self-administration: individual differences in male and female C57BL/6J mice by Griffin, W.C., Randall, P.K., Middaugh, L.D.

“…This study examined individual differences in male and female C57BL/6J (C57) mice responding for intravenous cocaine reinforcement. The experiment used 4…”
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COMT Genotype Influences the Effect of Alcohol on Blood Pressure: Results From the COMBINE Study by Stewart, Scott H., Oroszi, Gabor, Randall, Patrick K., Anton, Raymond F.

“…Background Heavy drinking can cause chronic hypertension, possibly due to effects on the autonomic nervous system. Catechol- O-methyltransferase (COMT)…”
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Comparison of Local and Systemic Ethanol Effects on Extracellular Dopamine Concentration in Rat Nucleus Accumbens by Microdialysis by Yim, Hyeon Joo, Schallert, Timothy, Randall, Patrick K., Gonzales, Rueben A.

“…To determine the site of action of systemic ethanol on dopaminergic function in the nucleus accumbens, we compared the effect of intraperitoneal (ip) and local…”
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Dissociation Between the Time Course of Ethanol and Extracellular Dopamine Concentrations in the Nucleus Accumbens After a Single Intraperitoneal Injection by Yim, Hyeon Joo, Robinson, Donita L., White, Martha L., Jaworski, Jason N., Randall, Patrick K., Lancaster, Francine E., Gonzales, Rueben A.

“…Background: Dopamine release in the nucleus accumbens has been linked to the reinforcing effects of ethanol, but the time course or relationship of this…”
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Acute ethanol affects phosphorylation state of the NMDA receptor complex: implication of tyrosine phosphatases and protein kinase A by Ferrani-Kile, K., Randall, P.K., Leslie, S.W.

“…Phosphorylation has been shown to regulate N-methyl- d-aspartic acid receptor (NMDAR) function. The inhibitory effect of ethanol on NMDAR function could be…”
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Effect of Prenatal Ethanol Exposure on the Developmental Profile of the NMDA Receptor Subunits in Rat Forebrain and Hippocampus by Hughes, Peter D., Kim, Young-Nam, Randall, Patrick K., Leslie, Steven W.

“…The effects of prenatal ethanol exposure on the NMDARl protein expression (postnatal days 1 and 7) and on the developmental profile of the NMDAR2A and NMDAR2B…”
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NR2B‐deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol by Badanich, K. A., Doremus‐Fitzwater, T. L., Mulholland, P. J., Randall, P. K., Delpire, E., Becker, H. C.

“…The NR2B subunit of N‐methyl d‐aspartate glutamate receptors influences pharmacological properties and confers greater sensitivity to the modulatory effects of…”
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Effects of prenatal ethanol exposure on N-methyl-D-aspartate-mediated calcium entry into dissociated neurons by Lee, Y H, Spuhler-Phillips, K, Randall, P K, Leslie, S W

“…The effects of prenatal ethanol exposure on N-methyl-D-aspartate (NMDA)-activated calcium entry into dissociated neurons were studied. Dissociated brain cells…”
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A longitudinal study of estrous cyclicity in aging C57BL/6J mice: I. Cycle frequency, length and vaginal cytology [Oestrous cycle, aging, vagina, cytology] by Nelson, J F, Felicio, L S, Randall, P K, Sims, C, Finch, C E

“…Cycle frequency, length, and vaginal cytology were measured longitudinally in three cohorts of singly housed virgin mice staggered across a 3-year interval…”
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Stimulation of N-methyl-D-aspartate receptor-mediated calcium entry into dissociated neurons by reduced and oxidized glutathione by Leslie, S W, Brown, L M, Trent, R D, Lee, Y H, Morris, J L, Jones, T W, Randall, P K, Lau, S S, Monks, T J

“…The effects of GSH (gamma-glutamylcysteinylglycine) and GSSG on intracellular calcium levels ([Ca2+]i) were investigated using fura-2-loaded dissociated brain…”
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Drinking to cope, emotional distress and alcohol use and abuse: a ten-year model by Holahan, C J, Moos, R H, Holahan, C K, Cronkite, R C, Randall, P K

“…This study examines the ability of baseline drinking to cope to predict drinking behavior across an ensuing 10-year period. In addition, it examines whether a…”
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Effects of the benzodiazepine antagonist flumazenil in PTSD by Randall, Penny K., Douglas Bremner, J., Krystal, John H., Nagy, Linda M., Heninger, George R., Nicolaou, Andreas L., Charney, Dennis S.

“…Objective: Evidence from preclinical and clinical studies suggests a role for alterations in the benzodiazepine/GABA A receptor complex in stress and anxiety…”
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Repeated perfusion with elevated potassium in in vivo microdialysis—A method for detecting small changes in extracellular dopamine by Ripley, Tamzin L, Jaworski, Jason, Randall, Patrick K, Gonzales, Rueben A

“…As a great deal of variability between subjects is often seen when using the microdialysis technique to measure the effects of depolarizing agents on…”
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NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol by Badanich, K. A., Doremus-Fitzwater, T. L., Mulholland, P. J., Randall, P. K., Delpire, E., Becker, H. C.

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Effect of Ethanol on Extracellular Dopamine in Rat Striatum by Direct Perfusion with Microdialysis by Yim, Hyeon Joo, Schallert, Timothy, Randall, Patrick K., Bungay, Peter M., Gonzales, Rueben A.

“…: The concentration‐related effects of ethanol on extracellular dopamine (DA) in rat striatum were studied by direct perfusion through microdialysis probes in…”
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A quantitative estimate of the role of striatal D-2 receptor proliferation in dopaminergic behavioral supersensitivity: the contribution of mesolimbic dopamine to the magnitude of 6-OHDA lesion-induced agonist sensitivity in the rat by Mandel, R J, Hartgraves, S L, Severson, J A, Woodward, J J, Wilcox, R E, Randall, P K

“…Rats with unilateral depletions of neostriatal dopamine display increased sensitivity to dopamine agonists estimated to be 30 to 100 x in the 6-hydroxydopamine…”
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Alteration of [3H]MK-801 binding associated with the N-methyl-D-Aspartate receptor complex by acute ethanol in rat cortex and hippocampus in vitro by Spuhler-Phillips, K, Gonzalez, J, Randall, P K, Leslie, S W

“…We investigated the effect of ethanol on specific binding of [3H]MK-801 to the intrachannel phencyclidine (PCP) receptor site, as an index of change in the…”
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A partial agonist model used in the allosteric modulation of the NMDA receptor by Robichon, Regine, Randall, Patrick K, Leslie, Steven W

“…We used a partial agonist model to understand further the allosteric modulation of d, l-( E)-2-amino-4-propyl-5-phosphono-3-pentenoic acid ([ 3H]CGP-39653)…”
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