Search Results - "Randall, Justin R."

Methyltransferase DnmA is responsible for genome-wide N6-methyladenosine modifications at non-palindromic recognition sites in Bacillus subtilis by Nye, Taylor M, van Gijtenbeek, Lieke A, Stevens, Amanda G, Schroeder, Jeremy W, Randall, Justin R, Matthews, Lindsay A, Simmons, Lyle A

“…The genomes of organisms from all three domains of life harbor endogenous base modifications in the form of DNA methylation. In bacterial genomes, methylation…”
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The sliding clamp tethers the endonuclease domain of MutL to DNA by Pillon, Monica C, Babu, Vignesh M P, Randall, Justin R, Cai, Jiudou, Simmons, Lyle A, Sutton, Mark D, Guarné, Alba

“…The sliding clamp enhances polymerase processivity and coordinates DNA replication with other critical DNA processing events including translesion synthesis,…”
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Mutagenic cost of ribonucleotides in bacterial DNA by Schroeder, Jeremy W., Randall, Justin R., Hirst, William G., O’Donnell, Michael E., Simmons, Lyle A.

“…Replicative DNA polymerases misincorporate ribonucleoside triphosphates (rNTPs) into DNA approximately once every 2,000 base pairs synthesized. Ribonucleotide…”
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RNase H genes cause distinct impacts on RNA:DNA hybrid formation and mutagenesis genome wide by Schroeder, Jeremy W, Hurto, Rebecca L, Randall, Justin R, Wozniak, Katherine J, Timko, Taylor A, Nye, Taylor M, Wang, Jue D, Freddolino, Peter L, Simmons, Lyle A

“…RNA:DNA hybrids compromise replication fork progression and genome integrity in all cells. The overall impacts of naturally occurring RNA:DNA hybrids on genome…”
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Synthetic antibacterial discovery of symbah-1, a macrocyclic β-hairpin peptide antibiotic by Randall, Justin R., Davidson, Gillian, Fleeman, Renee M., Acosta, Santos A., Riddington, Ian M., Cole, T. Jeffrey, DuPai, Cory D., Davies, Bryan W.

“…The rapid development and spread of antibiotic resistance necessitate the development of novel strategies for antibiotic discovery. Symbah-1, a synthetic…”
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Mining for novel antibiotics by Randall, Justin R, Davies, Bryan W

“…•Exploration of new microbial habitats provides opportunity for antibiotic discovery.•Computational approaches advance detection of hidden antibiotic…”
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Discovery of Antimicrobial Peptide Macrocycles Through Bacterial Display by Randall, Justin R, DuPai, Cory D, Davies, Bryan W

“…Peptide macrocycles exhibit great ability to inhibit bacterial growth making them a promising new avenue for antimicrobial discovery. Surface Localized…”
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Using display technologies to identify macrocyclic peptide antibiotics by Randall, Justin R, Wang, Xun, Groover, Kyra E, O'Donnell, Angela C, Davies, Bryan W

“…Antibiotic resistant bacterial infections are now a leading cause of global mortality. While drug resistance continues to spread, the clinical antibiotic…”
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Substrate Specificity for Bacterial RNases HII and HIII Is Influenced by Metal Availability by Randall, Justin R, Hirst, William G, Simmons, Lyle A

“…We tested the activities of four predicated RNase H enzymes, including two RNase HI-type enzymes, in addition to RNase HII (RnhB) and RNase HIII (RnhC), on…”
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RNase HIII Is Important for Okazaki Fragment Processing in Bacillus subtilis by Randall, Justin R, Nye, Taylor M, Wozniak, Katherine J, Simmons, Lyle A

“…RNA-DNA hybrids are common in chromosomal DNA. Persistent RNA-DNA hybrids result in replication fork stress, DNA breaks, and neurological disorders in humans…”
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Development of a Selective and Stable Antimicrobial Peptide by Groover, Kyra E., Randall, Justin R., Davies, Bryan W.

“…Antimicrobial peptides (AMPs) are presented as potential scaffolds for antibiotic development due to their desirable qualities including broad-spectrum…”
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Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity by Randall, Justin R., Vieira, Luiz C., Wilke, Claus O., Davies, Bryan W.

“…Many antimicrobial peptides directly disrupt bacterial membranes yet can also damage mammalian membranes. It is therefore central to their therapeutic use that…”
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Binding of the regulatory domain of MutL to the sliding β-clamp is species specific by Almawi, Ahmad W, Scotland, Michelle K, Randall, Justin R, Liu, Linda, Martin, Heather K, Sacre, Lauralicia, Shen, Yao, Pillon, Monica C, Simmons, Lyle A, Sutton, Mark D, Guarné, Alba

“…Abstract The β-clamp is a protein hub central to DNA replication and fork management. Proteins interacting with the β-clamp harbor a conserved clamp-binding…”
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Ribonucleotides in bacterial DNA by Schroeder, Jeremy W, Randall, Justin R, Matthews, Lindsay A, Simmons, Lyle A

“…In all living cells, DNA is the storage medium for genetic information. Being quite stable, DNA is well-suited for its role in storage and propagation of…”
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Adapting antibacterial display to identify serum-active macrocyclic peptide antibiotics by Randall, Justin R, Groover, Kyra E, O'Donnell, Angela C, Garza, Joseph M, Cole, T. Jeffrey, Davies, Bryan W

“…Abstract The lack of available treatments for many antimicrobial-resistant infections highlights the critical need for antibiotic discovery innovation…”
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Designing and identifying β-hairpin peptide macrocycles with antibiotic potential by Randall, Justin R, DuPai, Cory D, Cole, T Jeffrey, Davidson, Gillian, Groover, Kyra E, Slater, Sabrina L, Mavridou, Despoina A I, Wilke, Claus O, Davies, Bryan W

“…Peptide macrocycles are a rapidly emerging class of therapeutic, yet the design of their structure and activity remains challenging. This is especially true…”
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