Search Results - "Rand, Tim A"

The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes by Worringer, Kathleen A., Rand, Tim A., Hayashi, Yohei, Sami, Salma, Takahashi, Kazutoshi, Tanabe, Koji, Narita, Megumi, Srivastava, Deepak, Yamanaka, Shinya

“…Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) promotes a broad array of cellular changes. Here we show that the let-7…”
Get full text

Integration of tumor extrinsic and intrinsic features associates with immunotherapy response in non-small cell lung cancer by Lau, Denise, Khare, Sonal, Stein, Michelle M., Jain, Prerna, Gao, Yinjie, BenTaieb, Aicha, Rand, Tim A., Salahudeen, Ameen A., Khan, Aly A.

“…The efficacy of immune checkpoint blockade (ICB) varies greatly among metastatic non-small cell lung cancer (NSCLC) patients. Loss of heterozygosity at the…”
Get full text

Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity by Rand, T.A, Ginalski, K, Grishin, N.V, Wang, X

“…RNA interference is carried out by the small double-stranded RNA-induced silencing complex (RISC). The RISC-bound small RNA guides the RISC complex to identify…”
Get full text

Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells by Sugiyama, Hayami, Takahashi, Kazutoshi, Yamamoto, Takuya, Iwasaki, Mio, Narita, Megumi, Nakamura, Masahiro, Rand, Tim A., Nakagawa, Masato, Watanabe, Akira, Yamanaka, Shinya

“…Novel APOBEC1 target 1 (Nat1) (also known as “p97,” “Dap5,” and “Eif4g2”) is a ubiquitously expressed cytoplasmic protein that is homologous to the C-terminal…”
Get full text

MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition by Rand, Tim A., Sutou, Kenta, Tanabe, Koji, Jeong, Daeun, Nomura, Masaki, Kitaoka, Fumiyo, Tomoda, Emi, Narita, Megumi, Nakamura, Michiko, Nakamura, Masahiro, Watanabe, Akira, Rulifson, Eric, Yamanaka, Shinya, Takahashi, Kazutoshi

“…Here, we report that MYC rescues early human cells undergoing reprogramming from a proliferation pause induced by OCT3/4, SOX2, and KLF4 (OSK). We identified…”
Get full text

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation by Rand, Tim A., Petersen, Sean, Du, Fenghe, Wang, Xiaodong

“…The mRNA-cleavage step of RNA interference is mediated by an endonuclease, Argonaute2 (Ago2), within the RNA-induced silencing complex (RISC). Ago2 uses one…”
Get full text

R2D2, a Bridge between the Initiation and Effector Steps of the Drosophila RNAi Pathway by Liu, Qinghua, Rand, Tim A., Kalidas, Savitha, Du, Fenghe, Kim, Hyun-Eui, Smith, Dean P., Wang, Xiaodong

“…The RNA interference (RNAi) pathway is initiated by processing long double-stranded RNA into small interfering RNA (siRNA). The siRNA-generating enzyme was…”
Get full text

Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells by Kime, Cody, Rand, Tim A, Ivey, Kathryn N, Srivastava, Deepak, Yamanaka, Shinya, Tomoda, Kiichiro

“…The advent of induced pluripotent stem (iPS) cell technology has revolutionized biomedicine and basic research by yielding cells with embryonic stem (ES)…”
Get more information

Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells by Kime, Cody, Mandegar, Mohammad A, Srivastava, Deepak, Yamanaka, Shinya, Conklin, Bruce R, Rand, Tim A

“…Human pluripotent stem cells (hPS cells) are rapidly emerging as a powerful tool for biomedical discovery. The advent of human induced pluripotent stem cells…”
Get more information

Abstract 2281: A tumor-intrinsic signature involving immunosuppression via MIF-CD74 signaling is associated with overall survival in ICT-treated lung adenocarcinoma by Erbe, Rossin, Stein, Michelle M., Rand, Tim A., Guinney, Justin

“…Introduction: Immune checkpoint therapies (ICT) have changed cancer care, yielding robust and durable responses in a subset of patients. Identifying patients…”
Get full text

A pan-cancer organoid platform for precision medicine by Larsen, Brian M., Kannan, Madhavi, Langer, Lee F., Leibowitz, Benjamin D., Bentaieb, Aicha, Cancino, Andrea, Dolgalev, Igor, Drummond, Bridgette E., Dry, Jonathan R., Ho, Chi-Sing, Khullar, Gaurav, Krantz, Benjamin A., Mapes, Brandon, McKinnon, Kelly E., Metti, Jessica, Perera, Jason F., Rand, Tim A., Sanchez-Freire, Veronica, Shaxted, Jenna M., Stein, Michelle M., Streit, Michael A., Tan, Yi-Hung Carol, Zhang, Yilin, Zhao, Ende, Venkataraman, Jagadish, Stumpe, Martin C., Borgia, Jeffrey A., Masood, Ashiq, Catenacci, Daniel V.T., Mathews, Jeremy V., Gursel, Demirkan B., Wei, Jian-Jun, Welling, Theodore H., Simeone, Diane M., White, Kevin P., Khan, Aly A., Igartua, Catherine, Salahudeen, Ameen A.

“…Patient-derived tumor organoids (TOs) are emerging as high-fidelity models to study cancer biology and develop novel precision medicine therapeutics. However,…”
Get full text

The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Pro-differentiation Genes by Worringer, Kathleen A., Rand, Tim A., Hayashi, Yohei, Sami, Salma, Takahashi, Kazutoshi, Tanabe, Koji, Narita, Megumi, Srivastava, Deepak, Yamanaka, Shinya

“…Reprogramming differentiated cells into induced pluripotent stem cells (iPSCs) promotes a broad array of cellular changes. Here we show that the let-7 family…”
Get full text