Search Results - "Rancati, Giulia"

Aneuploidy and chromosomal instability in cancer: a jackpot to chaos by Giam, Maybelline, Rancati, Giulia

“…Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of mutations conferring aggressive or drug-resistant phenotypes during…”
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Experimental evolution of a fungal pathogen into a gut symbiont by Tso, Gloria Hoi Wan, Reales-Calderon, Jose Antonio, Tan, Alrina Shin Min, Sem, XiaoHui, Le, Giang Thi Thu, Tan, Tze Guan, Lai, Ghee Chuan, Srinivasan, K G, Yurieva, Marina, Liao, Webber, Poidinger, Michael, Zolezzi, Francesca, Rancati, Giulia, Pavelka, Norman

“…Gut microbes live in symbiosis with their hosts, but how mutualistic animal-microbe interactions emerge is not understood. By adaptively evolving the…”
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Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction by Tamborrini, Davide, Juanes, Maria Angeles, Ibanes, Sandy, Rancati, Giulia, Piatti, Simonetta

“…In many eukaryotic organisms cytokinesis is driven by a contractile actomyosin ring (CAR) that guides membrane invagination. What triggers CAR constriction at…”
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The Mutator Phenotype: Adapting Microbial Evolution to Cancer Biology by Natali, Federica, Rancati, Giulia

“…The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden,…”
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Karyotypic determinants of chromosome instability in aneuploid budding yeast by Zhu, Jin, Pavelka, Norman, Bradford, William D, Rancati, Giulia, Li, Rong

“…Recent studies in cancer cells and budding yeast demonstrated that aneuploidy, the state of having abnormal chromosome numbers, correlates with elevated…”
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The Greatwall kinase safeguards the genome integrity by affecting the kinome activity in mitosis by Bisteau, Xavier, Lee, Joann, Srinivas, Vinayaka, Lee, Joanna H. S., Niska-Blakie, Joanna, Tan, Gifford, Yap, Shannon Y. X., Hom, Kevin W., Wong, Cheng Kit, Chae, Jeongjun, Wang, Loo Chien, Kim, Jinho, Rancati, Giulia, Sobota, Radoslaw M., Tan, Chris S. H., Kaldis, Philipp

“…Progression through mitosis is balanced by the timely regulation of phosphorylation and dephosphorylation events ensuring the correct segregation of…”
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Transcriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53 by Potapova, Tamara A, Seidel, Christopher W, Box, Andrew C, Rancati, Giulia, Li, Rong

“…Tetraploidization, or genome doubling, is a prominent event in tumorigenesis, primarily because cell division in polyploid cells is error-prone and produces…”
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Meeting Report: Experimental and Evolutionary Approaches to Yeast and Other Organisms 2018 by Gresham, David, Rancati, Giulia

“…The 2018 European Molecular Biology Laboratory (EMBL) Experimental and Evolutionary Approaches to Yeast and Other Organisms conference brought together…”
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New perspectives on the role of biological factors in anorexia nervosa: Brain volume reduction or oxidative stress, which came first? by Gaiaschi, Ludovica, Priori, Erica Cecilia, Mensi, Martina Maria, Verri, Manuela, Buonocore, Daniela, Parisi, Sandra, Hernandez, Lilian Nathalie Quintero, Brambilla, Ilaria, Ferrari, Beatrice, De Luca, Fabrizio, Gola, Federica, Rancati, Giulia, Capone, Luca, Andriulo, Adele, Visonà, Silvia Damiana, Marseglia, Gian Luigi, Borgatti, Renato, Bottone, Maria Grazia

“…Anorexia nervosa (AN) is an eating disorder (ED) that has seen an increase in its incidence in the last thirty years. Compared to other psychosomatic…”
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Characterization of a panARS-based episomal vector in the methylotrophic yeast Pichia pastoris for recombinant protein production and synthetic biology applications by Camattari, Andrea, Goh, Amelia, Yip, Lian Yee, Tan, Andy Hee Meng, Ng, Sze Wai, Tran, Anthony, Liu, Gaowen, Liachko, Ivan, Dunham, Maitreya J, Rancati, Giulia

“…Recombinant protein production in the methylotrophic yeast Pichia pastoris largely relies on integrative vectors. Although the stability of integrated…”
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Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells by Trott, Jamie, Tan, Ee Kim, Ong, Sheena, Titmarsh, Drew M., Denil, Simon L.I.J., Giam, Maybelline, Wong, Cheng Kit, Wang, Jiaxu, Shboul, Mohammad, Eio, Michelle, Cooper-White, Justin, Cool, Simon M., Rancati, Giulia, Stanton, Lawrence W., Reversade, Bruno, Dunn, N. Ray

“…Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step…”
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Chromosomal instability-induced senescence potentiates cell non-autonomous tumourigenic effects by He, Qianqian, Au, Bijin, Kulkarni, Madhura, Shen, Yang, Lim, Kah. J., Maimaiti, Jiamila, Wong, Cheng. Kit, Luijten, Monique. N. H., Chong, Han C., Lim, Elaine H., Rancati, Giulia, Sinha, Indrajit, Fu, Zhiyan, Wang, Xiaomeng, Connolly, John. E., Crasta, Karen C.

“…Chromosomal instability (CIN), a high rate of chromosome loss or gain, is often associated with poor prognosis and drug resistance in cancers. Aneuploid,…”
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Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae by Nezi, Luigi, Rancati, Giulia, De Antoni, Anna, Pasqualato, Sebastiano, Piatti, Simonetta, Musacchio, Andrea

“…The spindle assembly checkpoint (SAC) coordinates mitotic progression with sister chromatid alignment. In mitosis, the checkpoint machinery accumulates at…”
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Cancer: a CINful evolution by Targa, Altea, Rancati, Giulia

“…Pioneering studies described cancer as an evolutionary process and detailed its intratumor heterogeneity in patients’ specimens. The development of unbiased…”
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A Chemically Defined Feeder-free System for the Establishment and Maintenance of the Human Naive Pluripotent State by Szczerbinska, Iwona, Gonzales, Kevin Andrew Uy, Cukuroglu, Engin, Ramli, Muhammad Nadzim Bin, Lee, Bertha Pei Ge, Tan, Cheng Peow, Wong, Cheng Kit, Rancati, Giulia Irene, Liang, Hongqing, Göke, Jonathan, Ng, Huck-Hui, Chan, Yun-Shen

“…The distinct states of pluripotency in the pre- and post-implantation embryo can be captured in vitro as naive and primed pluripotent stem cell cultures,…”
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Mad3/BubR1 Phosphorylation during Spindle Checkpoint Activation Depends on both Polo and Aurora Kinases in Budding Yeast by Rancati, Giulia, Crispo, Valentina, Lucchini, Giovanna, Piatti, Simonetta

“…During mitosis the spindle assembly checkpoint (SAC) delays the onset of anaphase and mitotic exit until all chromosomes are bipolarly attached to spindle…”
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Adaptive Evolution: Don’t Fix What’s Broken by Liu, Gaowen, Rancati, Giulia

“…Evolution of budding yeast after the removal of an important component of the polarization machinery, BEM1, followed reproducible evolutionary trajectories…”
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Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer by Pavelka, Norman, Rancati, Giulia, Li, Rong

“…When cells in our body change their genome and develop into cancer, we blame it on genome instability. When novel species conquer inhospitable environments, we…”
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The conditional nature of gene essentiality by Larrimore, Katherine E, Rancati, Giulia

“…Essential genes are classically defined as required for cellular viability and reproductive success. Despite this deceptively simple definition, several lines…”
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Emerging and evolving concepts in gene essentiality by Rancati, Giulia, Moffat, Jason, Typas, Athanasios, Pavelka, Norman

“…Key Points A gene is considered essential if it is required for the reproductive success of a cell or an organism. Gene essentiality is a core concept of…”
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