Search Results - "Ranatunga, K."

Temperature Effects on Force and Actin⁻Myosin Interaction in Muscle: A Look Back on Some Experimental Findings by Ranatunga, K W

“…Observations made in temperature studies on mammalian muscle during force development, shortening, and lengthening, are re-examined. The isometric force in…”
Get full text

The Location and Rate of the Phosphate Release Step in the Muscle Cross-Bridge Cycle by Offer, Gerald, Ranatunga, K.W.

“…It is controversial whether the phosphate (Pi) release step in the cross-bridge cycle occurs before or after the first tension-generating step and whether it…”
Get full text

Effects of Hydrostatic-Pressure on Muscle Contraction: A Look Back on Some Experimental Findings by Ranatunga, K W, Geeves, M A

“…Findings from experiments that used hydrostatic pressure changes to analyse the process of skeletal muscle contraction are re-examined. The force in resting…”
Get full text

A large electronic-health-record-based genome-wide study of serum lipids by Hoffmann, Thomas J., Theusch, Elizabeth, Haldar, Tanushree, Ranatunga, Dilrini K., Jorgenson, Eric, Medina, Marisa W., Kvale, Mark N., Kwok, Pui-Yan, Schaefer, Catherine, Krauss, Ronald M., Iribarren, Carlos, Risch, Neil

“…A genome-wide association study (GWAS) of 94,674 ancestrally diverse Kaiser Permanente members using 478,866 longitudinal electronic health record…”
Get full text

Reinterpretation of the Tension Response of Muscle to Stretches and Releases by Offer, Gerald, Ranatunga, K.W.

“…We have reexamined the experimental time courses of tension in frog muscle after rapid length steps. The early tension recoveries are biexponential. After…”
Get full text

The endothermic ATP hydrolysis and crossbridge attachment steps drive the increase of force with temperature in isometric and shortening muscle by Offer, Gerald, Ranatunga, K. W.

“…Key points Muscle performance increases with temperature in a wide variety of animals but has been studied most fully in frogs and mammals. While it has been…”
Get full text

The force-generation process in active muscle is strain sensitive and endothermic: a temperature-perturbation study by Ranatunga, K W, Offer, Gerald

“…In experiments on active muscle, we examined the tension decline and its temperature sensitivity at the onset of ramp shortening and at a range of velocities…”
Get full text

Force and power generating mechanism(s) in active muscle as revealed from temperature perturbation studies by Ranatunga, K. W.

“…The basic characteristics of the process of force and power generation in active muscle that have emerged from temperature studies are examined. This is done…”
Get full text

A Cross-Bridge Cycle with Two Tension-Generating Steps Simulates Skeletal Muscle Mechanics by Offer, Gerald, Ranatunga, K.W.

“…We examined whether cross-bridge cycle models with one or two tension-generating steps can account for the force-velocity relation of and tension response to…”
Get full text

Genetic stock structure of the silky shark Carcharhinus falciformis in the Indo-Pacific Ocean by Li, Chia-Yun Joanne, Tsai, Wen-Pei, Ranatunga, R. R. M. K. P, Samidon, Munandar, Liu, Shang Yin Vanson

“…The silky shark, Carcharhinus falciformis , is a cosmopolitan species commonly caught as a bycatch for longline fisheries. However, the genetic stock structure…”
Get full text

Dr Gerald W. Offer (1938–2019); an appreciation by Bennett, Pauline, Knight, Peter J., Ranatunga, K. W.

Get full text

Crossbridge and filament compliance in muscle: implications for tension generation and lever arm swing by Offer, Gerald, Ranatunga, K. W

“…The stiffness of myosin heads attached to actin is a crucial parameter in determining the kinetics and mechanics of the crossbridge cycle. It has been claimed…”
Get full text

Crossbridge and non-crossbridge contributions to tension in lengthening rat muscle: force-induced reversal of the power stroke by Pinniger, G. J., Ranatunga, K. W., Offer, G. W.

“…Lengthening of active muscle is an essential feature of animal locomotion, but the molecular processes occurring are incompletely understood. We therefore…”
Get full text

Skeletal muscle stiffness and contracture in children with spastic cerebral palsy by Ranatunga, K. W.

Get full text

Assessing the clinical impact of CYP2C9 pharmacogenetic variation on phenytoin prescribing practice and patient response in an integrated health system by Fohner, Alison E, Ranatunga, Dilrini K, Thai, Khanh K, Lawson, Brian L, Risch, Neil, Oni-Orisan, Akinyemi, Jelalian, Aline T, Rettie, Allan E, Liu, Vincent X, Schaefer, Catherine A

“…OBJECTIVETo assess the impact of CYP2C9 variation on phenytoin patient response and clinician prescribing practice where genotype was unknown during treatment…”
Get full text

On lateral transmission of force in active intact muscle by Ranatunga, K. W.

Get full text

Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin‐Induced Cutaneous Adverse Drug Reactions by Fohner, Alison E., Rettie, Allan E., Thai, Khanh K., Ranatunga, Dilrini K., Lawson, Brian L., Liu, Vincent X., Schaefer, Catherine A.

“…The role of cytochrome P450 (CYP)2C9 and CYP2C19 genetic variation in risk for phenytoin‐induced cutaneous adverse drug events is not well understood…”
Get full text

Slc26a9 Is Inhibited by the R-region of the Cystic Fibrosis Transmembrane Conductance Regulator via the STAS Domain by Chang, Min-Hwang, Plata, Consuelo, Sindic, Aleksandra, Ranatunga, Wasantha K., Chen, An-Ping, Zandi-Nejad, Kambiz, Chan, Kim W., Thompson, James, Mount, David B., Romero, Michael F.

“…SLC26 proteins function as anion exchangers, channels, and sensors. Previous cellular studies have shown that Slc26a3 and Slc26a6 interact with the R-region of…”
Get full text

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer by Hoffmann, Thomas J., Passarelli, Michael N., Graff, Rebecca E., Emami, Nima C., Sakoda, Lori C., Jorgenson, Eric, Habel, Laurel A., Shan, Jun, Ranatunga, Dilrini K., Quesenberry, Charles P., Chao, Chun R., Ghai, Nirupa R., Aaronson, David, Presti, Joseph, Nordström, Tobias, Wang, Zhaoming, Berndt, Sonja I., Chanock, Stephen J., Mosley, Jonathan D., Klein, Robert J., Middha, Mridu, Lilja, Hans, Melander, Olle, Kvale, Mark N., Kwok, Pui-Yan, Schaefer, Catherine, Risch, Neil, Van Den Eeden, Stephen K., Witte, John S.

“…Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa—such as…”
Get full text

Muscle fatigue examined at different temperatures in experiments on intact mammalian (rat) muscle fibers by Roots, H, Ball, G, Talbot-Ponsonby, J, King, M, McBeath, K, Ranatunga, K. W

“…Muscle Contraction Group, Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom Submitted 9…”
Get full text