Search Results - "Ranasinghe, Srinika"

HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function by CHEVALIER, Mathieu F, JIILG, Boris, CUTLER, Sam, MCANDREW, Elizabeth, JESSEN, Heiko, PEREYRA, Florencia, ROSENBERG, Eric S, ALTFELD, Marcus, WALKER, Bruce D, STREECK, Hendrik, PYO, Augustine, FLANDERS, Michael, RANASINGHE, Srinika, SOGHOIAN, Damien Z, KWON, Douglas S, RYCHERT, Jenna, LIAN, Jeffrey, MULLER, Matthias I

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HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome by RANASINGHE, Srinika, FLANDERS, Michael, STREECK, Hendrik, CUTLER, Sam, SOGHOIAN, Damien Z, GHEBREMICHAEL, Musie, DAVIS, Isaiah, LINDQVIST, Madelene, PEREYRA, Florencia, WALKER, Bruce D, HECKERMAN, David

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The antiviral efficacy of HIV-specific CD8⁺ T-cells to a conserved epitope is heavily dependent on the infecting HIV-1 isolate by Ranasinghe, Srinika R F, Kramer, Holger B, Wright, Cynthia, Kessler, Benedikt M, di Gleria, Katalin, Zhang, Yonghong, Gillespie, Geraldine M, Blais, Marie-Eve, Culshaw, Abigail, Pichulik, Tica, Simmons, Alison, Rowland-Jones, Sarah L, McMichael, Andrew J, Dong, Tao

“…A major challenge to developing a successful HIV vaccine is the vast diversity of viral sequences, yet it is generally assumed that an epitope conserved…”
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Differential Restriction of Human Immunodeficiency Virus Type 2 and Simian Immunodeficiency Virus SIVmac by TRIM5α Alleles by YLINEN, Laura M. J, KECKESOVA, Zuzana, WILSON, Sam J, RANASINGHE, Srinika, TOWERS, Greg J

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Multilayered defense in HLA-B51-associated HIV viral control by Zhang, YongHong, Peng, YanChun, Yan, HuiPing, Xu, Keyi, Saito, Masumichi, Wu, Hao, Chen, XinYue, Ranasinghe, Srinika, Kuse, Nozomi, Powell, Tim, Zhao, Yan, Li, WeiHua, Zhang, Xin, Feng, Xia, Li, Ning, Leligdowicz, Aleksandra, Xu, XiaoNing, John, Mina, Takiguchi, Masafumi, McMichael, Andrew, Rowland-Jones, Sarah, Dong, Tao

“…Polymorphism in the HLA region of a chromosome is the major source of host genetic variability in HIV-1 outcome, but there is limited understanding of the…”
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Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(L)-1 therapy: an open-label, multicentre, randomised, phase 2 trial by Schoenfeld, Jonathan D, Giobbie-Hurder, Anita, Ranasinghe, Srinika, Kao, Katrina Z, Lako, Ana, Tsuji, Junko, Liu, Yang, Brennick, Ryan C, Gentzler, Ryan D, Lee, Carrie, Hubbard, Joleen, Arnold, Susanne M, Abbruzzese, James L, Jabbour, Salma K, Uboha, Nataliya V, Stephans, Kevin L, Johnson, Jennifer M, Park, Haeseong, Villaruz, Liza C, Sharon, Elad, Streicher, Howard, Ahmed, Mansoor M, Lyon, Hayley, Cibuskis, Carrie, Lennon, Niall, Jhaveri, Aashna, Yang, Lin, Altreuter, Jennifer, Gunasti, Lauren, Weirather, Jason L, Mak, Raymond H, Awad, Mark M, Rodig, Scott J, Chen, Helen X, Wu, Catherine J, Monjazeb, Arta M, Hodi, F Stephen

“…Patients with non-small-cell lung cancer (NSCLC) that is resistant to PD-1 and PD-L1 (PD[L]-1)-targeted therapy have poor outcomes. Studies suggest that…”
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Expansion of HIV-specific T follicular helper cells in chronic HIV infection by Lindqvist, Madelene, van Lunzen, Jan, Soghoian, Damien Z, Kuhl, Bjorn D, Ranasinghe, Srinika, Kranias, Gregory, Flanders, Michael D, Cutler, Samuel, Yudanin, Naomi, Muller, Matthias I, Davis, Isaiah, Farber, Donna, Hartjen, Philip, Haag, Friedrich, Alter, Galit, Schulze zur Wiesch, Julian, Streeck, Hendrik

“…HIV targets CD4 T cells, which are required for the induction of high-affinity antibody responses and the formation of long-lived B cell memory. The depletion…”
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Programming CMV for vaccine vector design: viral vectors that elicit CD8 T-cell responses of unprecedented breadth and promiscuity may aid the design of improved HIV vaccines by Ranasinghe, Srinika, Walker, Bruce D

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A Randomized Trial of Combined PD-L1 and CTLA-4 Inhibition with Targeted Low-Dose or Hypofractionated Radiation for Patients with Metastatic Colorectal Cancer by Monjazeb, Arta M, Giobbie-Hurder, Anita, Lako, Ana, Thrash, Emily M, Brennick, Ryan C, Kao, Katrina Z, Manuszak, Claire, Gentzler, Ryan D, Tesfaye, Anteneh, Jabbour, Salma K, Alese, Olatunji B, Rahma, Osama E, Cleary, James M, Sharon, Elad, Mamon, Harvey J, Cho, May, Streicher, Howard, Chen, Helen X, Ahmed, Mansoor M, Mariño-Enríquez, Adrian, Kim-Schulze, Seunghee, Gnjatic, Sacha, Maverakis, Emanual, Marusina, Alina I, Merleev, Alexander A, Severgnini, Mariano, Pfaff, Kathleen L, Lindsay, James, Weirather, Jason L, Ranasinghe, Srinika, Spektor, Alexander, Rodig, Scott J, Hodi, Stephen F, Schoenfeld, Jonathan D

“…Prospective human data are lacking regarding safety, efficacy, and immunologic impacts of different radiation doses administered with combined PD-L1/CTLA-4…”
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Mechanisms of response and resistance to combined decitabine and ipilimumab for advanced myeloid disease by Penter, Livius, Liu, Yang, Wolff, Jacquelyn O., Yang, Lin, Taing, Len, Jhaveri, Aashna, Southard, Jackson, Patel, Manishkumar, Cullen, Nicole M., Pfaff, Kathleen L., Cieri, Nicoletta, Oliveira, Giacomo, Kim-Schulze, Seunghee, Ranasinghe, Srinika, Leonard, Rebecca, Robertson, Taylor, Morgan, Elizabeth A., Chen, Helen X., Song, Minkyung H., Thurin, Magdalena, Li, Shuqiang, Rodig, Scott J., Cibulskis, Carrie, Gabriel, Stacey, Bachireddy, Pavan, Ritz, Jerome, Streicher, Howard, Neuberg, Donna S., Hodi, F. Stephen, Davids, Matthew S., Gnjatic, Sacha, Livak, Kenneth J., Altreuter, Jennifer, Michor, Franziska, Soiffer, Robert J., Garcia, Jacqueline S., Wu, Catherine J.

“…•Response associates with higher T cell to AML ratio, whereas resistance is marked by insufficient clearing of diseased progenitor cells.•Distinct T-cell…”
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Mitochondrial DNA Mutations Distinguish Individual Donor- and Recipient-Derived Immune Cells Following Matched Unrelated Allogeneic Stem Cell Transplantation by Penter, Livius, Southard, Jackson, Li, Shuqiang, Lareau, Caleb A., Ludwig, Leif S., Cieri, Nicoletta, Maurer, Alexandria, DeAngelo, Daniel J., Ranasinghe, Srinika, Neuberg, Donna S., Sankaran, Vijay G., Soiffer, Robert J., Livak, Kenneth J., Garcia, Jacqueline S., Wu, Catherine J.

“…▪ Reconstitution of donor hematopoiesis after allogeneic hematopoietic stem cell transplantation (HSCT) forms the basis for effective graft-versus-leukemia…”
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HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome by Soghoian, Damien Z, Jessen, Heiko, Flanders, Michael, Sierra-Davidson, Kailan, Cutler, Sam, Pertel, Thomas, Ranasinghe, Srinika, Lindqvist, Madelene, Davis, Isaiah, Lane, Kimberly, Rychert, Jenna, Rosenberg, Eric S, Piechocka-Trocha, Alicja, Brass, Abraham L, Brenchley, Jason M, Walker, Bruce D, Streeck, Hendrik

“…Early immunological events during acute HIV infection are thought to fundamentally influence long-term disease outcome. Whereas the contribution of…”
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Association of HLA-DRB1–restricted CD4+ T cell responses with HIV immune control by Ranasinghe, Srinika, Cutler, Sam, Davis, Isaiah, Lu, Richard, Soghoian, Damien Z, Qi, Ying, Sidney, John, Kranias, Gregory, Flanders, Michael D, Lindqvist, Madelene, Kuhl, Bjorn, Alter, Galit, Deeks, Steven G, Walker, Bruce D, Gao, Xiaojiang, Sette, Alessandro, Carrington, Mary, Streeck, Hendrik

“…CD8 + T cell responses have been associated with control of HIV replication, but the role of CD4 + T cells in protecting against this virus is unclear. In an…”
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HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer + Gag-Specific CD4 + T Cells in Chronic Clade C HIV-1 Infection by Laher, Faatima, Ranasinghe, Srinika, Porichis, Filippos, Mewalal, Nikoshia, Pretorius, Karyn, Ismail, Nasreen, Buus, Søren, Stryhn, Anette, Carrington, Mary, Walker, Bruce D, Ndung'u, Thumbi, Ndhlovu, Zaza M

“…Immune control of viral infections is heavily dependent on helper CD4 T cell function. However, the understanding of the contribution of HIV-specific CD4 T…”
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Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation by Penter, Livius, Zhang, Yi, Savell, Alexandra, Huang, Teddy, Cieri, Nicoletta, Thrash, Emily M., Kim-Schulze, Seunghee, Jhaveri, Aashna, Fu, Jingxin, Ranasinghe, Srinika, Li, Shuqiang, Zhang, Wandi, Hathaway, Emma S., Nazzaro, Matthew, Kim, Haesook T., Chen, Helen, Thurin, Magdalena, Rodig, Scott J., Severgnini, Mariano, Cibulskis, Carrie, Gabriel, Stacey, Livak, Kenneth J., Cutler, Corey, Antin, Joseph H., Nikiforow, Sarah, Koreth, John, Ho, Vincent T., Armand, Philippe, Ritz, Jerome, Streicher, Howard, Neuberg, Donna, Hodi, F. Stephen, Gnjatic, Sacha, Soiffer, Robert J., Liu, X. Shirley, Davids, Matthew S., Bachireddy, Pavan, Wu, Catherine J.

“…Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune…”
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Mechanisms of Response and Resistance to Combination Decitabine and Ipilimumab for Transplant Naïve and Post-Transplant AML/MDS by Penter, Livius, Liu, Yang, Yang, Lin, Taing, Len, Jhaveri, Aashna, Southard, Jackson, Patel, Manishkumar, Wolff, Jacquelyn, Cullen, Nicole, Pfaff, Kathleen, Cieri, Nicoletta, Oliveira, Giacomo, Kim-Schulze, Seunghee, Ranasinghe, Srinika, Leonard, Rebecca, Robertson, Taylor, Chen, Helen, Thurin, Magdalena, Li, Shuqiang, Rodig, Scott J., Cibulskis, Carrie, Gabriel, Stacey, Ritz, Jerome, Streicher, Howard, Neuberg, Donna S., Hodi, Stephen, Gnjatic, Sacha, Livak, Kenneth J, Altreuter, Jennifer, Michor, Franziska, Soiffer, Robert J, Garcia, Jacqueline S., Wu, Catherine J.

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Programming CMV for vaccine vector design by Ranasinghe, Srinika, Walker, Bruce D

“…Viral vectors that elicit CD8 T-cell responses of unprecedented breadth and promiscuity may aid the design of improved HIV vaccines…”
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HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses by Ranasinghe, Srinika, Soghoian, Damien Z, Lindqvist, Madelene, Ghebremichael, Musie, Donaghey, Faith, Carrington, Mary, Seaman, Michael S, Kaufmann, Daniel E, Walker, Bruce D, Porichis, Filippos

“…Antigen-specific CD4(+) T helper cell responses have long been recognized to be a critical component of effective vaccine immunity. CD4(+) T cells are…”
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Immune Profiling Mass Cytometry Assay Harmonization: Multicenter Experience from CIMAC-CIDC by Sahaf, Bita, Pichavant, Mina, Lee, Brian H, Duault, Caroline, Thrash, Emily M, Davila, Melanie, Fernandez, Nicolas, Millerchip, Karen, Bentebibel, Salah-Eddine, Haymaker, Cara, Sigal, Natalia, Del Valle, Diane M, Ranasinghe, Srinika, Fayle, Sarah, Sanchez-Espiridion, Beatriz, Zhang, Jiexin, Bernatchez, Chantale, Wu, Catherine J, Wistuba, Ignacio I, Kim-Schulze, Seunghee, Gnjatic, Sacha, Bendall, Sean C, Song, Minkyung, Thurin, Magdalena, Lee, J Jack, Maecker, Holden T, Rahman, Adeeb

“…The Cancer Immune Monitoring and Analysis Centers - Cancer Immunologic Data Commons (CIMAC-CIDC) Network is supported by the NCI to identify biomarkers of…”
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Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion by Ranasinghe, Srinika, Lamothe, Pedro A., Soghoian, Damien Z., Kazer, Samuel W., Cole, Michael B., Shalek, Alex K., Yosef, Nir, Jones, R. Brad, Donaghey, Faith, Nwonu, Chioma, Jani, Priya, Clayton, Gina M., Crawford, Frances, White, Janice, Montoya, Alana, Power, Karen, Allen, Todd M., Streeck, Hendrik, Kaufmann, Daniel E., Picker, Louis J., Kappler, John W., Walker, Bruce D.

“…CD8+ T cell recognition of virus-infected cells is characteristically restricted by major histocompatibility complex (MHC) class I, although rare examples of…”
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