Search Results - "Ranasinghe, Shiwanthi"

Schistosomiasis—from immunopathology to vaccines by McManus, Donald P., Bergquist, Robert, Cai, Pengfei, Ranasinghe, Shiwanthi, Tebeje, Biniam Mathewos, You, Hong

“…Schistosomiasis (bilharzia) is a neglected tropical disease caused by trematode worms of the genus Schistosoma . The transmission cycle involves human (or…”
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Kunitz type protease inhibitor EgKI-1 from the canine tapeworm Echinococcus granulosus as a promising therapeutic against breast cancer by Ranasinghe, Shiwanthi L, Boyle, Glen M, Fischer, Katja, Potriquet, Jeremy, Mulvenna, Jason P, McManus, Donald P

“…EgKI-1, a member of the Kunitz type protease inhibitor family, is highly expressed by the oncosphere of the canine tapeworm Echinococcus granulosus, the stage…”
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Structure and function of invertebrate Kunitz serine protease inhibitors by Ranasinghe, Shiwanthi, McManus, Donald P.

“…► Kunitz type proteins are a family of serine protease inhibitors. ► They exhibit canonical inhibitory mechanism. ► Kunitz motif consists of six conserved…”
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Cloning and Characterization of Two Potent Kunitz Type Protease Inhibitors from Echinococcus granulosus by Ranasinghe, Shiwanthi L, Fischer, Katja, Zhang, Wenbao, Gobert, Geoffrey N, McManus, Donald P

“…The tapeworm Echinococcus granulosus is responsible for cystic echinococcosis (CE), a cosmopolitan disease which imposes a significant burden on the health and…”
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Protease Inhibitors of Parasitic Flukes: Emerging Roles in Parasite Survival and Immune Defence by Ranasinghe, Shiwanthi L, McManus, Donald P

“…Protease inhibitors play crucial roles in parasite development and survival, counteracting the potentially damaging immune responses of their vertebrate hosts…”
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Kunitz type protease inhibitor from the canine tapeworm as a potential therapeutic for melanoma by Ranasinghe, Shiwanthi L., Rivera, Vanessa, Boyle, Glen M., McManus, Donald P.

“…Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer…”
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Bioinformatic comparison of Kunitz protease inhibitors in Echinococcus granulosus sensu stricto and E. multilocularis and the genes expressed in different developmental stages of E. granulosus s.s by Zhang, Hui, Tian, Mengxiao, Qi, Wenjing, Wu, Juan, Zheng, Huajun, Guo, Gang, Zhang, Liang, Ranasinghe, Shiwanthi L, McManus, Donald P, Li, Jun, Zhang, Wenbao

“…Cystic and alveolar echinococcosis caused by the tapeworms Echinococcus granulosus sensu stricto (s.s.) and E. multilocularis, respectively, are important…”
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Kunitz-type protease inhibitor as a vaccine candidate against schistosomiasis mansoni by Ranasinghe, Shiwanthi L., Duke, Mary, Harvie, Marina, McManus, Donald P.

“…[Display omitted] •The vaccination of mice with rSmKI-1 resulted in reduced numbers of parasites and eggs.•The rSmKI-1 vaccine produced a solid IgG response,…”
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Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni by Ranasinghe, Shiwanthi L, Fischer, Katja, Gobert, Geoffrey N, McManus, Donald P

“…Schistosomes are able to survive for prolonged periods in the blood system, despite continuous contact with coagulatory factors and mediators of the host…”
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A novel coagulation inhibitor from Schistosoma japonicum by Ranasinghe, Shiwanthi L, Fischer, Katja, Gobert, Geoffrey N, McManus, Donald P

“…Little is known about the molecular mechanisms whereby the human blood fluke Schistosoma japonicum is able to survive in the host venous blood system. Protease…”
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Use of kinase inhibitors against schistosomes to improve and broaden praziquantel efficacy by Nawaratna, Sujeevi S. K., McManus, Donald P., Gasser, Robin B., Brindley, Paul J., Boyle, Glen M., Rivera, Vanessa, Ranasinghe, Shiwanthi L., Jones, Malcolm K., You, Hong, Gobert, Geoffrey N.

“…Praziquantel (PZQ) is the drug of choice for schistosomiasis. The potential drug resistance necessitates the search for adjunct or alternative therapies to…”
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Correction to: Schistosomiasis—from immunopathology to vaccines by McManus, Donald P., Bergquist, Robert, Cai, Pengfei, Ranasinghe, Shiwanthi, Tebeje, Biniam Mathewos, You, Hong

“…The original version of this article inadvertently missed out to display the correct acknowledgement for Fig. 2. The corrected part of legend of Fig. 2 is…”
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Echinococcus granulosus : Cure for Cancer Revisited by Ranasinghe, Shiwanthi L, McManus, Donald P

“…Whereas a number of parasites are well recognized risk factors for a number of different cancers in mammalian hosts, there is limited information on the…”
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Gene Expression in Developmental Stages of Schistosoma japonicum Provides Further Insight into the Importance of the Schistosome Insulin-Like Peptide by Du, Xiaofeng, Jones, Malcolm K, Nawaratna, Sujeevi S K, Ranasinghe, Shiwanthi, Xiong, Chunrong, Cai, Pengfei, McManus, Donald P, You, Hong

“…We showed previously that the insulin-like peptide (SjILP) binds the worm insulin receptors, thereby, activating the parasite's insulin pathway and emphasizing…”
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CRISPR/Cas9‐mediated genome editing of Schistosoma mansoni acetylcholinesterase by You, Hong, Mayer, Johannes U., Johnston, Rebecca L., Sivakumaran, Haran, Ranasinghe, Shiwanthi, Rivera, Vanessa, Kondrashova, Olga, Koufariotis, Lambros T., Du, Xiaofeng, Driguez, Patrick, French, Juliet D., Waddell, Nicola, Duke, Mary G., Ittiprasert, Wannaporn, Mann, Victoria H., Brindley, Paul J., Jones, Malcolm K., McManus, Donald P.

“…CRISPR/Cas9‐mediated genome editing shows cogent potential for the genetic modification of helminth parasites. We report successful gene knock‐in (KI) into the…”
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Cloning and Characterization of Two Potent Kunitz Type Protease Inhibitors from Echinococcus granulosus: e0004268 by Ranasinghe, Shiwanthi L, Fischer, Katja, Zhang, Wenbao, Gobert, Geoffrey N, McManus, Donald P

“…The tapeworm Echinococcus granulosus is responsible for cystic echinococcosis (CE), a cosmopolitan disease which imposes a significant burden on the health and…”
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