Search Results - "Rana, Nadia A."

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors by Rana, Nadia A, Haltiwanger, Robert S

“…► Notch is modified at multiple sites with O-fucose and O-glucose glycans ► Elongation of O-fucose glycans by Fringe regulates Notch-ligand binding. ► Rumi…”
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Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch by Harvey, Beth M., Rana, Nadia A., Moss, Hillary, Leonardi, Jessica, Jafar-Nejad, Hamed, Haltiwanger, Robert S.

“…Glycosylation of the Notch receptor is essential for its activity and serves as an important modulator of signaling. Three major forms of O-glycosylation are…”
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O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1 by Rana, Nadia A., Nita-Lazar, Aleksandra, Takeuchi, Hideyuki, Kakuda, Shinako, Luther, Kelvin B., Haltiwanger, Robert S.

“…Notch activity is regulated by both O-fucosylation and O-glucosylation, and Notch receptors contain multiple predicted sites for both. Here we examine the…”
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Negative regulation of notch signaling by xylose by Lee, Tom V, Sethi, Maya K, Leonardi, Jessica, Rana, Nadia A, Buettner, Falk F R, Haltiwanger, Robert S, Bakker, Hans, Jafar-Nejad, Hamed

“…The Notch signaling pathway controls a large number of processes during animal development and adult homeostasis. One of the conserved post-translational…”
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A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands by Yamamoto, Shinya, Charng, Wu-Lin, Rana, Nadia A., Kakuda, Shinako, Jaiswal, Manish, Bayat, Vafa, Xiong, Bo, Zhang, Ke, Sandoval, Hector, David, Gabriela, Wang, Hao, Haltiwanger, Robert S., Bellen, Hugo J.

“…Notch signaling affects many developmental and cellular processes and has been implicated in congenital disorders, stroke, and numerous cancers. The Notch…”
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O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function by Müller, Julia, Rana, Nadia A, Serth, Katrin, Kakuda, Shinako, Haltiwanger, Robert S, Gossler, Achim

“…Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in Drosophila) is pivotal for NOTCH…”
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Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae[S] by Ren, Jihui, Snider, Justin, Airola, Michael V., Zhong, Aaron, Rana, Nadia A., Obeid, Lina M., Hannun, Yusuf A.

“…Serine palmitoyltransferase (SPT) catalyzes the rate-limiting step of condensation of L-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (3KDS). Here,…”
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Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase by Takeuchi, Hideyuki, Fernández-Valdivia, Rodrigo C, Caswell, Devin S, Nita-Lazar, Aleksandra, Rana, Nadia A, Garner, Thomas P, Weldeghiorghis, Thomas K, Macnaughtan, Megan A, Jafar-Nejad, Hamed, Haltiwanger, Robert S

“…Mutations in rumi result in a temperature-sensitive loss of Notch signaling in DROSOPHILA: Drosophila Rumi is a soluble, endoplasmic reticulum-retained protein…”
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In Vitro Reconstitution of the Modulation of Drosophila Notch-Ligand Binding by Fringe by Xu, Aiguo, Haines, Nicola, Dlugosz, Malgosia, Rana, Nadia A., Takeuchi, Hideyuki, Haltiwanger, Robert S., Irvine, Kenneth D.

“…Notch signaling plays critical roles in animal development and physiology. The activation of Notch receptors by their ligands is modulated by Fringe-dependent…”
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Functional UDP-xylose Transport across the Endoplasmic Reticulum/Golgi Membrane in a Chinese Hamster Ovary Cell Mutant Defective in UDP-xylose Synthase by Bakker, Hans, Oka, Takuji, Ashikov, Angel, Yadav, Ajit, Berger, Monika, Rana, Nadia A., Bai, Xiaomei, Jigami, Yoshifumi, Haltiwanger, Robert S., Esko, Jeffrey D., Gerardy-Schahn, Rita

“…In mammals, xylose is found as the first sugar residue of the tetrasaccharide GlcAβ1-3Galβ1-3Galβ1-4Xylβ1-O-Ser, initiating the formation of the…”
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Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets by Senkal, Can E., Salama, Mohamed F., Snider, Ashley J., Allopenna, Janet J., Rana, Nadia A., Koller, Antonius, Hannun, Yusuf A., Obeid, Lina M.

“…In an approach aimed at defining interacting partners of ceramide synthases (CerSs), we found that fatty acyl-CoA synthase ACSL5 interacts with all CerSs. We…”
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Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling by Acar, Melih, Jafar-Nejad, Hamed, Takeuchi, Hideyuki, Rajan, Akhila, Ibrani, Dafina, Rana, Nadia A., Pan, Hongling, Haltiwanger, Robert S., Bellen, Hugo J.

“…Notch signaling is broadly used to regulate cell-fate decisions. We have identified a gene, rumi, with a temperature-sensitive Notch phenotype. At 28°C–30°C,…”
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Negative Regulation of Notch Signaling by Xylose: e1003547 by Lee, Tom V, Sethi, Maya K, Leonardi, Jessica, Rana, Nadia A, Buettner, Falk FR, Haltiwanger, Robert S, Bakker, Hans, Jafar-Nejad, Hamed

“…The Notch signaling pathway controls a large number of processes during animal development and adult homeostasis. One of the conserved post-translational…”
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Rumi, a CAP10 domain protein, is a glycosyltransferase that modifies Notch and is required for Notch signaling by Acar, Melih, Jafar-Nejad, Hamed, Takeuchi, Hideyuki, Rajan, Akhila, Ibrani, Dafina, Rana, Nadia A., Pan, Hongling, Haltiwanger, Robert S., Bellen, Hugo J.

“…Notch signaling is broadly used to regulate cell fate decisions. We have identified a novel gene, rumi, with a temperature-sensitive Notch phenotype. At…”
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On the “Fringe” of Notch: Mapping O-Fucose and O-Glucose Glycans at Specific Sites on the Extracellular Domains of Notch Receptors Using Nano-LC-ESI-MS/MS by Rana, Nadia A

“…Notch is an essential cell surface receptor whose proper functioning is critical during development in metazoans. Notch can be modified with two unique forms…”
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On the "Fringe" of Notch: Mapping O-Fucose and O-Glucose Glycans at Specific Sites on the Extracellular Domains of Notch Receptors Using Nano-LC-ESI-MS/MS by Rana, Nadia A

“…Notch is an essential cell surface receptor whose proper functioning is critical during development in metazoans. Notch can be modified with two unique forms…”
Get full text