Search Results - "Rana, Isma"

MRI Tumor Regression Grade and Circulating Tumor DNA as Complementary Tools to Assess Response and Guide Therapy Adaptation in Rectal Cancer by Khakoo, Shelize, Carter, Paul David, Brown, Gina, Valeri, Nicola, Picchia, Simona, Bali, Maria Antonietta, Shaikh, Ridwan, Jones, Thomas, Begum, Ruwaida, Rana, Isma, Wotherspoon, Andrew, Terlizzo, Monica, von Loga, Katharina, Kalaitzaki, Eleftheria, Saffery, Claire, Watkins, David, Tait, Diana, Chau, Ian, Starling, Naureen, Hubank, Michael, Cunningham, David

“…Response to preoperative chemo-radiotherapy (CRT) varies. We assessed whether circulating tumor DNA (ctDNA) might be an early indicator of tumor response or…”
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ctDNA guided adjuvant chemotherapy versus standard of care adjuvant chemotherapy after curative surgery in patients with high risk stage II or stage III colorectal cancer: a multi-centre, prospective, randomised control trial (TRACC Part C) by Slater, Susanna, Bryant, Annette, Chen, Hsiang-Chi, Begum, Ruwaida, Rana, Isma, Aresu, Maria, Peckitt, Clare, Zhitkov, Oleg, Lazaro-Alcausi, Retchel, Borja, Victoria, Powell, Rachel, Lowery, David, Hubank, Michael, Rich, Thereasa, Anandappa, Gayathri, Chau, Ian, Starling, Naureen, Cunningham, David

“…Circulating tumour DNA (ctDNA) to detect minimal residual disease (MRD) is emerging as a biomarker to predict recurrence in patients with curatively treated…”
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Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study by Khan, Khurum, Rata, Mihaela, Cunningham, David, Koh, Dow-Mu, Tunariu, Nina, Hahne, Jens C, Vlachogiannis, George, Hedayat, Somaieh, Marchetti, Silvia, Lampis, Andrea, Damavandi, Mahnaz Darvish, Lote, Hazel, Rana, Isma, Williams, Anja, Eccles, Suzanne A, Fontana, Elisa, Collins, David, Eltahir, Zakaria, Rao, Sheela, Watkins, David, Starling, Naureen, Thomas, Jan, Kalaitzaki, Eleftheria, Fotiadis, Nicos, Begum, Ruwaida, Bali, Maria, Rugge, Massimo, Temple, Eleanor, Fassan, Matteo, Chau, Ian, Braconi, Chiara, Valeri, Nicola

“…Regorafenib demonstrated efficacy in patients with metastatic colorectal cancer (mCRC). Lack of predictive biomarkers, potential toxicities and…”
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Ibrutinib in c-MYC and HER2 Amplified Oesophagogastric Carcinoma: Results of the Proof-of-Concept iMYC Study by Turkes, Fiona, Bryant, Annette, Begum, Ruwaida, Davidson, Michael, Kalaitzaki, Eleftheria, Aresu, Maria, Lazaro-Alcausi, Retchel, Bryant, Jane, Rana, Isma, Chua, Sue, Aronson, Lauren, Hulkki-Wilson, Sanna, Fribbens, Charlotte, Watkins, David, Rao, Sheela, Starling, Naureen, Cunningham, David, Chong, Irene Y, Chau, Ian

“…Oesophagogastric (OG) cancer is a highly lethal disease requiring novel treatment options. c-MYC and/or HER-2 amplified oesophageal cancer models have…”
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Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer by Woolston, Andrew, Khan, Khurum, Spain, Georgia, Barber, Louise J., Griffiths, Beatrice, Gonzalez-Exposito, Reyes, Hornsteiner, Lisa, Punta, Marco, Patil, Yatish, Newey, Alice, Mansukhani, Sonia, Davies, Matthew N., Furness, Andrew, Sclafani, Francesco, Peckitt, Clare, Jiménez, Mirta, Kouvelakis, Kyriakos, Ranftl, Romana, Begum, Ruwaida, Rana, Isma, Thomas, Janet, Bryant, Annette, Quezada, Sergio, Wotherspoon, Andrew, Khan, Nasir, Fotiadis, Nikolaos, Marafioti, Teresa, Powles, Thomas, Lise, Stefano, Calvo, Fernando, Guettler, Sebastian, von Loga, Katharina, Rao, Sheela, Watkins, David, Starling, Naureen, Chau, Ian, Sadanandam, Anguraj, Cunningham, David, Gerlinger, Marco

“…Despite biomarker stratification, the anti-EGFR antibody cetuximab is only effective against a subgroup of colorectal cancers (CRCs). This genomic and…”
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Impact of infiltrating T cell subtypes on survival and response to FLOT chemotherapy in resectable oesophagogastric adenocarcinoma (OGA) by Athauda, Avani, Silveira, Tatiany, Lund, Thomas, von Loga, Katharina, Challoner, Benjamin, Rana, Isma, Thomas, Janet, Starling, Naureen, Chau, Ian, Rao, Sheela, Watkins, David J., Cunningham, David, Gerlinger, Marco

“…443 Background: The prognostic and predictive relevance of tumour infiltrating T cell subtypes and of PD-L1 expression in localised OGA treated with FLOT…”
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miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial by Anandappa, Gayathri, Lampis, Andrea, Cunningham, David, Khan, Khurum H, Kouvelakis, Kyriakos, Vlachogiannis, Georgios, Hedayat, Somaieh, Tunariu, Nina, Rao, Sheela, Watkins, David, Starling, Naureen, Braconi, Chiara, Darvish-Damavandi, Mahnaz, Lote, Hazel, Thomas, Janet, Peckitt, Clare, Kalaitzaki, Ria, Khan, Nasir, Fotiadis, Nicos, Rugge, Massimo, Begum, Ruwaida, Rana, Isma, Bryant, Annette, Hahne, Jens C, Chau, Ian, Fassan, Matteo, Valeri, Nicola

“…Anti-EGFR mAbs are effective in the treatment of metastatic colorectal cancer (mCRC) patients. status and tumor location (sidedness) are predictive markers of…”
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Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing by Mansukhani, Sonia, Barber, Louise J, Kleftogiannis, Dimitrios, Moorcraft, Sing Yu, Davidson, Michael, Woolston, Andrew, Proszek, Paula Zuzanna, Griffiths, Beatrice, Fenwick, Kerry, Herman, Bram, Matthews, Nik, O'Leary, Ben, Hulkki, Sanna, Gonzalez De Castro, David, Patel, Anisha, Wotherspoon, Andrew, Okachi, Aleruchi, Rana, Isma, Begum, Ruwaida, Davies, Matthew N, Powles, Thomas, von Loga, Katharina, Hubank, Michael, Turner, Nick, Watkins, David, Chau, Ian, Cunningham, David, Lise, Stefano, Starling, Naureen, Gerlinger, Marco

“…Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes, but highly sensitive and specific technologies are necessary to accurately…”
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Primary results of the ICONIC phase 2 trial of perioperative FLOT plus avelumab (FLOT-A) in operable oesophagogastric adenocarcinoma (OGA) by Gordon, Anderley, Challoner, Benjamin, Athauda, Avani, Woolston, Andrew, Mansukhani, Sonia, Dunstan, Matt, Petrou, Nikoletta, Khabra, Komel, Lazaro-Alcausi, Retchel, Crux, Richard, Borja, Victoria, Begum, Ruwaida, Rana, Isma, Rao, Sheela, Kumar, Sacheen, Cunningham, David, Chau, Ian, Starling, Naureen, Chaudry, M. Asif, Gerlinger, Marco

“…446 Background: ICONIC evaluated 4+4 cycles of FLOT-A (2-weekly standard FLOT with 10mg/kg of the anti-PDL1 antibody avelumab) for perioperative treatment of…”
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Perioperative FLOT plus anti-PD-L1 avelumab (FLOT-A) in resectable oesophagogastric adenocarcinoma (OGA): Interim safety analysis results from the ICONIC trial by Athauda, Avani, Starling, Naureen, Chau, Ian, Cunningham, David, Watkins, David J., Rao, Sheela, Kalaitzaki, Eleftheria, Bourmpaki, Elli, Davidson, Michael, Gillbanks, Angela, Lazaro-Alcausi, Retchel, Moneypenny, Michael, Begum, Ruwaida, von Loga, Katharina, Rana, Isma, Patel, Pranav, Doran, Sophie, Kumar, Sacheen, Chaudry, Asif, Gerlinger, Marco

“…Abstract only 201 Background: ICONIC is a single-arm phase II trial investigating the safety and efficacy of perioperative FLOT-A in resectable OGA. Following…”
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Prospective analysis of microRNA 31-3p (miR31-3p) as a predictive biomarker of response to anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies (mABs) in patients with metastatic colorectal cancer (mCRC) by Anandappa, Gayathri, Lampis, Andrea, Cunningham, David, Kouvelakis, Kyriakos, Khan, Khurum, Vlachogiannis, George, Tunariu, Nina, Rao, Sheela, Watkins, David, Starling, Naureen, Braconi, Chiara, Peckitt, Clare, Thomas, Janet, Rana, Isma, Begum, Ruwaida, Bryant, Annette, Hahne, Jens, Chau, Ian, Fassan, Matteo, Valeri, Nicola

“…Abstract only 548 Background: RAS status in tissue and/or liquid biopsies and tumour location (sidedness) are predictive markers of patients’ response to…”
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Clonal diversity of MYC amplification evaluated by fluorescent in situ hybridisation and digital droplet polymerase chain reaction in oesophagogastric cancer: Results from a prospective clinical trial screening programme by Davidson, Michael, Aronson, Lauren I., Howard-Reeves, Julie, Bryant, Hanna, Cutts, Rosalind J., Hulkki-Wilson, Sanna, Kouvelakis, Kyriakos, Kalaitzaki, Eftheleria, Watkins, David, Starling, Naureen, Rao, Sheela, Cardenosa, Marta Llorca, Begum, Ruwaida, Rana, Isma, Lazaro-Alcausi, Retchel, Terlizzo, Monica, Wotherspoon, Andrew, Brown, Gina, Swansbury, John, Lord, Christopher J., Cunningham, David, Chau, Ian, Chong, Irene Y.

“…The MYC proto-oncogene is among the most commonly dysregulated genes in human cancers. We report screening data from the iMYC trial, an ongoing phase II study…”
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Abstract 4339: Molecular subtypes and novel genetic mechanisms of primary and acquired anti-EGFR resistance in colorectal cancer in the Prospect C biomarker trial by Khan, Khurum Hayat, Woolston, Andrew, Spain, Georgia, Barber, Louise, Patil, Yatish, Griffiths, Beatrice, GonzalezExposito, Reyes, Mansukhani, Sonia, Davies, Matthew, Rao, Sheela, Watkins, David, Sclafani, Francesco, Suntharanathan, Jana, Peckitt, Clare, Begum, Ruwaida, Rana, Isma, Thomas, Janet, Oates, Jacqui, Bryant, Annette, Wotherspoon, Andrew, Fotiadis, Nicos, Khan, Nasir, Guettler, Sebastian, Loga, Katharina von, Starling, Naureen, Chau, Ian, Sadanandam, Anguraj, Cunningham, David, Gerlinger, Marco

“…Abstract Despite stratification of only RAS wt CRCs for anti-EGFR antibody (aEa) therapy, many patients (pts) do not benefit and the molecular resistance (res)…”
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Detecting and Tracking Circulating Tumour DNA Copy Number Profiles during First Line Chemotherapy in Oesophagogastric Adenocarcinoma by Davidson, Michael, Barber, Louise J, Woolston, Andrew, Cafferkey, Catherine, Mansukhani, Sonia, Griffiths, Beatrice, Moorcraft, Sing-Yu, Rana, Isma, Begum, Ruwaida, Assiotis, Ioannis, Matthews, Nik, Rao, Sheela, Watkins, David, Chau, Ian, Cunningham, David, Starling, Naureen, Gerlinger, Marco

“…DNA somatic copy number aberrations (SCNAs) are key drivers in oesophagogastric adenocarcinoma (OGA). Whether minimally invasive SCNA analysis of circulating…”
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Abstract 5591: Circulating tumor DNA for recurrence prediction and efficacy analysis in the ICONIC trial of peri-operative FLOT and avelumab (PD-L1) in localized esophago-gastric adenocarcinoma by Gerlinger, Marco, Gordon, Anderley, Barber, Louise J., Laliotis, Georgios, Athauda, Avani, Challoner, Benjamin, Woolston, Andrew, Mansukhani, Sonia, Dunstan, Matt, Petrou, Nikoletta, Khabra, Komel, Lazaro-Alcausi, Retchel, Crux, Richard, Borja, Victoria, Begum, Ruwaida, Rana, Isma, Palsuledesai, Charuta, Malhotra, Meenakshi, Liu, Minetta, Jurdi, Adham, Sharma, Shruti, Rao, Sheela, Kumar, Sacheen, Cunningham, David, Chau, Ian, Starling, Naureen, Chaudry, M Asif

“…Abstract Background: The utility of molecular residual disease (MRD) detection by circulating tumor (ct)DNA in early-stage (pT2+ or N+, M0) esophagogastric…”
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Metastatic colorectal cancer (mCRC) patient derived organoids (PDOs) as a preclinical tool to understand mechanisms of resistance to anti-angiogenic drugs by Hedayat, Somaieh, Vlachogiannis, George, Jamin, Yann, Khan, Khurum, Fernandez-mateos, Javier, Hahne, Jens C., Rata, Michaela, Koh, Dow-Ku, Tunariu, Nina, Collins, David, Bali, Monia, Chau, Ian, Rao, Sheela, Watkins, David, Sterling, Naureen, Fotoadis, Nicos, Huntingford, Ian, Gegum, Ruwaida, Rana, Isma, Rugge, Massimo, Braconi, Chiara, Fassan, Matteo, Eccles, Suzanne, Robinson, Simon P., Cunningham, David, Valeri, Nicola

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Metastatic colorectal cancer (mCRC) patient derived organoids (PDOs) as a preclinical tool to understand mechanisms of resistance to anti-angiogenic drugs by Hedayat, Somaieh, Vlachogiannis, George, Jamin, Yann, Khan, Khurum, Fernandez-mateos, Javier, Hahne, Jens C., Rata, Michaela, Koh, Dow-Ku, Tunariu, Nina, Collins, David, Bali, Monia, Chau, Ian, Rao, Sheela, Watkins, David, Sterling, Naureen, Fotoadis, Nicos, Huntingford, Ian, Gegum, Ruwaida, Rana, Isma, Rugge, Massimo, Braconi, Chiara, Fassan, Matteo, Eccles, Suzanne, Robinson, Simon P., Cunningham, David, Valeri, Nicola

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