Search Results - "Ramu Elango"

Integrative weighted molecular network construction from transcriptomics and genome wide association data to identify shared genetic biomarkers for COPD and lung cancer by Babajan Banaganapalli, Bayan Mallah, Kawthar Saad Alghamdi, Walaa F Albaqami, Dalal Sameer Alshaer, Nuha Alrayes, Ramu Elango, Noor A Shaik

“…Chronic obstructive pulmonary disease (COPD) is a multifactorial progressive airflow obstruction in the lungs, accounting for high morbidity and mortality…”
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The use of therapeutic drug monitoring for early identification of vedolizumab response in Saudi Arabian patients with inflammatory bowel disease by Anbarserry, Doaa, Mosli, Mahmoud, Qari, Yousef, Saadah, Omar, Bokhary, Rana, Esmat, Ahmed, Alsieni, Mohammed, Shaker, Ahmed, Elango, Ramu, Alharthi, Sameer

“…Vedolizumab is a humanized monoclonal antibody used to treat moderate-to-severe inflammatory bowel disease (IBD). The aim of the study was to assess the…”
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Integrative weighted molecular network construction from transcriptomics and genome wide association data to identify shared genetic biomarkers for COPD and lung cancer by Banaganapalli, Babajan, Mallah, Bayan, Alghamdi, Kawthar Saad, Albaqami, Walaa F, Alshaer, Dalal Sameer, Alrayes, Nuha, Elango, Ramu, Shaik, Noor A

“…Chronic obstructive pulmonary disease (COPD) is a multifactorial progressive airflow obstruction in the lungs, accounting for high morbidity and mortality…”
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Identification of miRNA–mRNA–TFs regulatory network and crucial pathways involved in asthma through advanced systems biology approaches by Shaik, Noor Ahmad, Nasser, Khalidah, Mohammed, Arif, Mujalli, Abdulrahman, Obaid, Ahmad A, El-Harouni, Ashraf A, Elango, Ramu, Banaganapalli, Babajan

“…Asthma is a life-threatening and chronic inflammatory lung disease that is posing a true global health challenge. The genetic basis of the disease is fairly…”
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Paget's disease: a review of the epidemiology, etiology, genetics, and treatment by Banaganapalli, Babajan, Fallatah, Ibrahim, Alsubhi, Fai, Shetty, Preetha Jayasheela, Awan, Zuhier, Elango, Ramu, Shaik, Noor Ahmad

“…Paget's disease of bone (PDB) is the second most prevalent metabolic bone disorder worldwide, with a prevalence rate of 1.5%-8.3%. It is characterized by…”
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Exploring celiac disease candidate pathways by global gene expression profiling and gene network cluster analysis by Banaganapalli, Babajan, Mansour, Haifa, Mohammed, Arif, Alharthi, Arwa Mastoor, Aljuaid, Nada Mohammed, Nasser, Khalidah Khalid, Ahmad, Aftab, Saadah, Omar I., Al-Aama, Jumana Yousuf, Elango, Ramu, Shaik, Noor Ahmad

“…Celiac disease (CeD) is a gastrointestinal autoimmune disorder, whose specific molecular basis is not yet fully interpreted. Therefore, in this study, we…”
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Bioinformatics insights into the genes and pathways on severe COVID-19 pathology in patients with comorbidities by Mujalli, Abdulrahman, Alghamdi, Kawthar Saad, Nasser, Khalidah Khalid, Al-Rayes, Nuha, Banaganapalli, Babajan, Shaik, Noor Ahmad, Elango, Ramu

“…Coronavirus disease (COVID-19) infection is known for its severe clinical pathogenesis among individuals with pre-existing comorbidities. However, the…”
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Identification of key regulatory genes connected to NF-κB family of proteins in visceral adipose tissues using gene expression and weighted protein interaction network by Sabir, Jamal S M, El Omri, Abdelfatteh, Shaik, Noor A, Banaganapalli, Babajan, Al-Shaeri, Majed A, Alkenani, Naser A, Hajrah, Nahid H, Awan, Zuhier A, Zrelli, Houda, Elango, Ramu, Khan, Muhummadh

“…Obesity is connected to the activation of chronic inflammatory pathways in both adipocytes and macrophages located in adipose tissues. The nuclear factor…”
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A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers by Shinawi, Thoraia, Nasser, Khalidah Khalid, Moradi, Fatima Amanullah, Mujalli, Abdulrahman, Albaqami, Walaa F., Almukadi, Haifa S., Elango, Ramu, Shaik, Noor Ahmad, Banaganapalli, Babajan

“…Background: Prostate cancer (PC) is a fatally aggressive urogenital cancer killing millions of men, globally. Thus, this study aims to identify key miRNAs,…”
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Computational approaches for discovering significant microRNAs, microRNA-mRNA regulatory pathways, and therapeutic protein targets in endometrial cancer by Ajabnoor, Ghada, Alsubhi, Fai, Shinawi, Thoraia, Habhab, Wisam, Albaqami, Walaa F, Alqahtani, Hussain S, Nasief, Hisham, Bondagji, Nabeel, Elango, Ramu, Shaik, Noor Ahmad, Banaganapalli, Babajan

“…Endometrial cancer (EC) is a urogenital cancer affecting millions of post-menopausal women, globally. This study aims to identify key miRNAs, target genes, and…”
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LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study by Hulihan, Mary M, MPH, Ishihara-Paul, Lianna, PhD, Kachergus, Jennifer, BSc, Warren, Liling, PhD, Amouri, Rim, PhD, Elango, Ramu, PhD, Prinjha, Rab K, PhD, Upmanyu, Ruchi, MSc, Kefi, Mounir, MD, Zouari, Mourad, MD, Sassi, Samia Ben, MD, Yahmed, Samia Ben, MD, El Euch-Fayeche, Ghada, MD, Matthews, Paul M, PhD, Middleton, Lefkos T, MD, Gibson, Rachel A, PhD, Hentati, Fayçal, MD, Farrer, Matthew J, PhD

“…Summary Background Several genes have been implicated in the pathogenesis of Parkinson's disease (PD). The aim of this study was to define the clinical…”
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In-silico analysis of inflammatory bowel disease (IBD) GWAS loci to novel connections by Mesbah-Uddin, Md, Elango, Ramu, Banaganapalli, Babajan, Shaik, Noor Ahmad, Al-Abbasi, Fahad A

“…Genome-wide association studies (GWASs) for many complex diseases, including inflammatory bowel disease (IBD), produced hundreds of disease-associated loci-the…”
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Protein structural insights into a rare PCSK9 gain-of-function variant (R496W) causing familial hypercholesterolemia in a Saudi family: whole exome sequencing and computational analysis by Shaik, Noor Ahmad, Al-Shehri, Najla, Athar, Mohammad, Awan, Ahmed, Khalili, Mariam, Al Mahadi, Hadiah Bassam, Hejazy, Gehan, Saadah, Omar I, Al-Harthi, Sameer Eida, Elango, Ramu, Banaganapalli, Babajan, Alefishat, Eman, Awan, Zuhier

“…Familial hypercholesterolemia (FH) is a globally underdiagnosed genetic condition associated with premature cardiovascular death. The genetic etiology data on…”
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Unraveling the role of salt-sensitivity genes in obesity with integrated network biology and co-expression analysis by Sabir, Jamal Sabir M, El Omri, Abdelfatteh, Banaganapalli, Babajan, Aljuaid, Nada, Omar, Abdulkader M Shaikh, Altaf, Abdulmalik, Hajrah, Nahid H, Zrelli, Houda, Arfaoui, Leila, Elango, Ramu, Alharbi, Mona G, Alhebshi, Alawiah M, Jansen, Robert K, Shaik, Noor A, Khan, Muhummadh

“…Obesity is a multifactorial disease caused by complex interactions between genes and dietary factors. Salt-rich diet is related to the development and…”
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Integrative system biology and mathematical modeling of genetic networks identifies shared biomarkers for obesity and diabetes by Bima, Abdulhadi Ibrahim H, Elsamanoudy, Ayman Zaky, Albaqami, Walaa F, Khan, Zeenath, Parambath, Snijesh Valiya, Al-Rayes, Nuha, Kaipa, Prabhakar Rao, Elango, Ramu, Banaganapalli, Babajan, Shaik, Noor A

“…Obesity and type 2 and diabetes mellitus (T2D) are two dual epidemics whose shared genetic pathological mechanisms are still far from being fully understood…”
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Whole exome sequencing of a consanguineous family identifies the possible modifying effect of a globally rare AK5 allelic variant in celiac disease development among Saudi patients by Al-Aama, Jumana Yousuf, Shaik, Noor Ahmad, Banaganapalli, Babajan, Salama, Mohammed A, Rashidi, Omran, Sahly, Ahmed N, Mohsen, Mohammed O, Shawoosh, Harbi A, Shalabi, Hebah Ahmad, Edreesi, Mohammad Al, Alharthi, Sameer E, Wang, Jun, Elango, Ramu, Saadah, Omar I

“…Celiac disease (CD), a multi-factorial auto-inflammatory disease of the small intestine, is known to occur in both sporadic and familial forms. Together HLA…”
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Expanded Somatic Mutation Spectrum of MED12 Gene in Uterine Leiomyomas of Saudi Arabian Women by Ajabnoor, Ghada M A, Mohammed, Nesma Amin, Banaganapalli, Babajan, Abdullah, Layla Saleh, Bondagji, Ola Nabeel, Mansouri, Nisma, Sahly, Nora Naif, Vaidyanathan, Venkatesh, Bondagji, Nabeel, Elango, Ramu, Shaik, Noor Ahmad

“…MED12, a subunit of mediator complex genes is known to harbor genetic mutations, (mostly in exon 2), causal to the genesis of uterine leiomyomas among…”
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Dissecting the Role of NF-κb Protein Family and Its Regulators in Rheumatoid Arthritis Using Weighted Gene Co-Expression Network by Sabir, Jamal S M, El Omri, Abdelfatteh, Banaganapalli, Babajan, Al-Shaeri, Majed A, Alkenani, Naser A, Sabir, Mumdooh J, Hajrah, Nahid H, Zrelli, Houda, Ciesla, Lukasz, Nasser, Khalidah K, Elango, Ramu, Shaik, Noor Ahmad, Khan, Muhummadh

“…Rheumatoid arthritis (RA) is a chronic synovial autoinflammatory disease that destructs the cartilage and bone, leading to disability. The functional…”
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Potential Biomarkers for Parkinson Disease from Functional Enrichment and Bioinformatic Analysis of Global Gene Expression Patterns of Blood and Substantia Nigra Tissues by Elango, Ramu, Banaganapalli, Babajan, Mujalli, Abdulrahman, AlRayes, Nuha, Almaghrabi, Sarah, Almansouri, Majid, Sahly, Ahmed, Jadkarim, Gada Ali, Malik, Md Zubbair, Kutbi, Hussam Ibrahim, Shaik, Noor Ahmad, Alefishat, Eman

“…The Parkinson disease (PD) is the second most common neurodegenerative disorder affecting the central nervous system and motor functions. The biological…”
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Genome-Wide Association Study-Guided Exome Rare Variant Burden Analysis Identifies IL1R1 and CD3E as Potential Autoimmunity Risk Genes for Celiac Disease by Mansour, Haifa, Banaganapalli, Babajan, Nasser, Khalidah Khalid, Al-Aama, Jumana Yousuf, Shaik, Noor Ahmad, Saadah, Omar Ibrahim, Elango, Ramu

“…Celiac disease (CeD) is a multifactorial autoimmune enteropathy characterized by the overactivation of the immune system in response to dietary gluten. The…”
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