Search Results - "Ramsey, Joanne M."

Effective nebulization of interferon-γ using a novel vibrating mesh by Sweeney, Louise, McCloskey, Alice P, Higgins, Gerard, Ramsey, Joanne M, Cryan, Sally-Ann, MacLoughlin, Ronan

“…Interferon gamma (IFN-γ) is a clinically relevant immunomodulatory cytokine that has demonstrated significant potential in the treatment and management of…”
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Biopolymer-Based Nanoparticles for Cystic Fibrosis Lung Gene Therapy Studies by Fernández Fernández, Elena, Santos-Carballal, Beatriz, de Santi, Chiara, Ramsey, Joanne M, MacLoughlin, Ronan, Cryan, Sally-Ann, Greene, Catherine M

“…Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore,…”
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Nebulised lipid-polymer hybrid nanoparticles for the delivery of a therapeutic anti-inflammatory microRNA to bronchial epithelial cells by Vencken, Sebastian, Foged, Camilla, Ramsey, Joanne M, Sweeney, Louise, Cryan, Sally-Ann, MacLoughlin, Ronan J, Greene, Catherine M

“…Modulation of microRNAs (miRNAs), endogenous regulators of gene expression, is a promising strategy for tackling inflammatory lung diseases. In this…”
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In Vitro and In Vivo Assessment of PEGylated PEI for Anti-IL-8/CxCL-1 siRNA Delivery to the Lungs by Hibbitts, Alan J., Ramsey, Joanne M., Barlow, James, MacLoughlin, Ronan, Cryan, Sally-Ann

“…Inhalation offers a means of rapid, local delivery of siRNA to treat a range of autoimmune or inflammatory respiratory conditions. This work investigated the…”
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Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene‐Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia by Ramsey, Joanne M., Kettyle, Laura M.J., Sharpe, Daniel J., Mulgrew, Nuala M., Dickson, Glenda J., Bijl, Janet J., Austin, Pamela, Mayotte, Nadine, Cellot, Sonia, Lappin, Terence R.J., Zhang, Shu‐Dong, Mills, Ken I., Krosl, Jana, Sauvageau, Guy, Thompson, Alexander

“…The incidence of refractory acute myeloid leukemia (AML) is on the increase due in part to an aging population that fails to respond to traditional therapies…”
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c‐Met inhibition in a HOXA9/Meis1 model of CN‐AML by Mulgrew, Nuala M., Kettyle, Laura M.J., Ramsey, Joanne M., Cull, Susan, Smyth, Laura J., Mervyn, Danielle M., Bijl, Janet J., Thompson, Alexander

“…ABSTRACT Background: Hematopoiesis is a paradigm for developmental processes, hierarchically organized, with stem cells at its origin. Hematopoietic stem cells…”
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Knockdown of Gene Expression in Macrophages by microRNA Mimic-Containing Poly (Lactic- co -glycolic Acid) Microparticles by McKiernan, Paul J, Lynch, Patrick, Ramsey, Joanne M, Cryan, Sally Ann, Greene, Catherine M

“…microRNA (miRNA) regulate target gene expression through translational repression and/or mRNA degradation and are involved in the regulation of inflammation…”
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Effective nebulization of interferon-[gamma] using a novel vibrating mesh by Sweeney, Louise, McCloskey, Alice P, Higgins, Gerard, Ramsey, Joanne M, Cryan, Sally-Ann, MacLoughlin, Ronan

“…Background Interferon gamma (IFN-[gamma]) is a clinically relevant immunomodulatory cytokine that has demonstrated significant potential in the treatment and…”
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Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells by Tivnan, Amanda, Heilinger, Tatjana, Ramsey, Joanne M, O'Connor, Gemma, Pokorny, Jenny L, Sarkaria, Jann N, Stringer, Brett W, Day, Bryan W, Boyd, Andrew W, Kim, Ella L, Lode, Holger N, Cryan, Sally-Ann, Prehn, Jochen H M

“…Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We…”
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Therapeutic Aerosol Bioengineering of siRNA for the Treatment of Inflammatory Lung Disease by TNFα Gene Silencing in Macrophages by Kelly, Ciara, Yadav, Awadh B, Lawlor, Ciaran, Nolan, Katie, O’Dwyer, Joanne, Greene, Catherine M, McElvaney, Noel G, Sivadas, Neeraj, Ramsey, Joanne M, Cryan, Sally-Ann

“…The development of small interfering RNA (siRNA) to silence specific genes offers a new means of understanding and treating a range of respiratory diseases,…”
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Low-dose salinomycin induces anti-leukemic responses in AML and MLL by Roulston, Gary D R, Burt, Charlotte L, Kettyle, Laura M J, Matchett, Kyle B, Keenan, Heather L, Mulgrew, Nuala M, Ramsey, Joanne M, Dougan, Caoifa, McKiernan, John, Grishagin, Ivan V, Mills, Ken I, Thompson, Alexander

“…Development of anti-cancer drugs towards clinical application is costly and inefficient. Large screens of drugs, efficacious for non-cancer disease, are…”
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High-throughput methods for screening liposome-macrophage cell interaction by Kelly, Ciara, Lawlor, Ciaran, Burke, Colin, Barlow, James W., Ramsey, Joanne M., Jefferies, Caroline, Cryan, Sally-Ann

“…Carriers are often an essential element of drug delivery, bestowing attributes to their cargo such as biocompatibility, enhanced delivery, extended half-life…”
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'Smart' non-viral delivery systems for targeted delivery of RNAi to the lungs by Ramsey, Joanne M, Hibbitts, Alan, Barlow, James, Kelly, Ciara, Sivadas, Neeraj, Cryan, Sally-Ann

“…The emergence of RNAi offers a potentially exciting new therapeutic paradigm for respiratory diseases. However, effective delivery remains a key requirement…”
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Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis by Wheadon, Helen, Ramsey, Joanne M, Dobbin, Edwina, Dickson, Glenda J, Corrigan, Pamela M, Freeburn, Robin W, Thompson, Alexander

“…The Hox family are master transcriptional regulators of developmental processes, including hematopoiesis. The Hox regulators, caudal homeobox factors (Cdx1-4),…”
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