Dipyrrolidinomethylaminophosphoric acid triamide (DPMPA) as an activator for the samarium diiodide-mediated reduction of alkyl and aryl halides

Dipyrrolidinomethylaminophosphoric acid triamide (DPMPA) as an activator for the samarium diiodide-mediated reduction of alkyl and aryl halides

The use of the conjugate base of dipyrrolidinomethylaminophosphoric triamide (DPMPA−) as an activator of samarium diiodide is reported. This phosphoramidate has been shown to be a very potent ligand, allowing for the efficient, low-temperature reduction of alkyl and aryl chlorides. Reductive cycliza...

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Bibliographic Details
Published in:Tetrahedron Vol. 69; no. 14; pp. 2947 - 2953
Main Authors: McDonald, Chriss E., Ramsey, Jeremy R., Sampsell, David G., Anderson, Laura A., Krebs, Jordan E., Smith, Samantha N.
Format: Journal Article
Language:English
Published: Elsevier Ltd 08-04-2013
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Summary:The use of the conjugate base of dipyrrolidinomethylaminophosphoric triamide (DPMPA−) as an activator of samarium diiodide is reported. This phosphoramidate has been shown to be a very potent ligand, allowing for the efficient, low-temperature reduction of alkyl and aryl chlorides. Reductive cyclizations of haloalkenylnaphthalenes are also reported. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.02.025