Search Results - "Ramsden, Jeremy I."

Imine reductases (IREDs) by Mangas-Sanchez, Juan, France, Scott P, Montgomery, Sarah L, Aleku, Godwin A, Man, Henry, Sharma, Mahima, Ramsden, Jeremy I, Grogan, Gideon, Turner, Nicholas J

“…•Imine reductases (IREDs) enable the asymmetric synthesis of amines from imines.•The development of annotated sequence databases has led to the discovery of…”
Get full text

Biocatalytic N‑Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades by Ramsden, Jeremy I, Heath, Rachel S, Derrington, Sasha R, Montgomery, Sarah L, Mangas-Sanchez, Juan, Mulholland, Keith R, Turner, Nicholas J

“…The alkylation of amines with either alcohols or carboxylic acids represents a mild and safe alternative to the use of genotoxic alkyl halides and sulfonate…”
Get full text

Is it time for biocatalysis in fragment-based drug discovery? by Ramsden, Jeremy I, Cosgrove, Sebastian C, Turner, Nicholas J

“…The use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of…”
Get full text

A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases by Sharma, Mahima, Mangas-Sanchez, Juan, France, Scott P, Aleku, Godwin A, Montgomery, Sarah L, Ramsden, Jeremy I, Turner, Nicholas J, Grogan, Gideon

“…Reductive aminases (RedAms) catalyze the asymmetric reductive amination of ketones with primary amines to give secondary amine products. RedAms have great…”
Get full text

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases by Mangas-Sanchez, Juan, Sharma, Mahima, Cosgrove, Sebastian C, Ramsden, Jeremy I, Marshall, James R, Thorpe, Thomas W, Palmer, Ryan B, Grogan, Gideon, Turner, Nicholas J

“…Chiral primary amines are important intermediates in the synthesis of pharmaceutical compounds. Fungal reductive aminases (RedAms) are NADPH-dependent…”
Get full text

Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N‑Heterocycles by Ramsden, Jeremy I., Zucoloto da Costa, Bruna, Heath, Rachel S., Marshall, James R., Derrington, Sasha R., Mangas-Sanchez, Juan, Montgomery, Sarah L., Mulholland, Keith R., Cosgrove, Sebastian C., Turner, Nicholas J.

“…Saturated N-heterocycles constitute a vital scaffold for pharmaceutical chemistry but are challenging to access synthetically, particularly asymmetrically…”
Get full text

Natural heterogeneous catalysis with immobilised oxidase biocatalysts by Mattey, Ashley P, Sangster, Jack J, Ramsden, Jeremy I, Baldwin, Christopher, Birmingham, William R, Heath, Rachel S, Angelastro, Antonio, Turner, Nicholas J, Cosgrove, Sebastian C, Flitsch, Sabine L

“…The generation of immobilised oxidase biocatalysts allowing multifunctional oxidation of valuable chemicals using molecular oxygen is described. Engineered…”
Get full text

Redox surrogate methods for sustainable amine N-alkylation by Ruscoe, Rebecca E, Ramsden, Jeremy I, Turner, Nicholas J

“…The N-alkylation of amines constitutes one of the most widely applied transformations in synthetic chemistry, but established methods often utilise…”
Get full text

Imine Reductases, Reductive Aminases, and Amine Oxidases for the Synthesis of Chiral Amines: Discovery, Characterization, and Synthetic Applications by Cosgrove, Sebastian C, Brzezniak, Agata, France, Scott P, Ramsden, Jeremy I, Mangas-Sanchez, Juan, Montgomery, Sarah L, Heath, Rachel S, Turner, Nicholas J

“…Synthesis of the chiral amine moiety is a key challenge for synthetic organic chemistry due to its prevalence in many biologically active molecules. Imine…”
Get more information