Search Results - "Ramsdell, F"

Left–right asymmetry and congenital cardiac defects: Getting to the heart of the matter in vertebrate left–right axis determination by Ramsdell, Ann F.

“…Cellular and molecular left–right differences that are present in the mesodermal heart fields suggest that the heart is lateralized from its inception…”
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Introduction to provocative questions in left–right asymmetry by Levin, Michael, Klar, Amar J. S., Ramsdell, Ann F.

“…Left–right asymmetry is a phenomenon that has a broad appeal—to anatomists, developmental biologists and evolutionary biologists—because it is a morphological…”
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Mammary glands exhibit molecular laterality and undergo left–right asymmetric ductal epithelial growth in MMTV-cNeu mice by Robichaux, J P, Hallett, R M, Fuseler, J W, Hassell, J A, Ramsdell, A F

“…Significant left–right (L–R) differences in tumor incidence and disease outcome occur for cancers of paired organs, including the breasts; however, the basis…”
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Development of a large-scale H3.3K27M-specific TCR-transduced T cell manufacturing method for adoptive cell therapy in HLA-A2+ patients with diffuse midline glioma by Okada, K, Nguyen, A, Watchmaker, P, Xu, J, Ramsdell, F, Esensten, J.H, Butterfield, L.H, Okada, H

“…Background & AimDiffuse midline glioma (DMG), including diffuse intrinsic pontine glioma (DIPG), constitutes up to 20% of pediatric brain cancer and has a…”
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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 by Ochs, Hans D, Bennett, Craig L, Christie, Jacinda, Ramsdell, Fred, Brunkow, Mary E, Ferguson, Polly J, Whitesell, Luke, Kelly, Thaddeus E, Saulsbury, Frank T, Chance, Phillip F

“…IPEX is a fatal disorder characterized by immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (MIM 304930). We present genetic…”
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Scurfy, the Foxp3 locus, and the molecular basis of peripheral tolerance by Appleby, M W, Ramsdell, F

“…The ability to rapidly and efficiently recognize and eliminate pathogens while sparing normal self tissue is a hallmark of the mammalian immune system. When it…”
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Left-right lineage analysis of the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects and laterality disease by Ramsdell, Ann F, Bernanke, Jayne M, Trusk, Thomas C

“…The significant morbidity and mortality associated with laterality disease almost always are attributed to complex congenital heart defects (CHDs), reflecting…”
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Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice by Peschon, J J, Morrissey, P J, Grabstein, K H, Ramsdell, F J, Maraskovsky, E, Gliniak, B C, Park, L S, Ziegler, S F, Williams, D E, Ware, C B, Meyer, J D, Davison, B L

“…Interleukin 7 (IL-7) stimulates the proliferation of B cell progenitors, thymocytes, and mature T cells through an interaction with a high affinity receptor…”
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Developmental toxicity of domoic acid in zebrafish ( Danio rerio) by Tiedeken, Jessica A., Ramsdell, John S., Ramsdell, Ann F.

“…Domoic acid (DA) is a rigid analog of the excitatory amino acid glutamate. It is produced by the diatom genus Pseudo-nitzschia and is a potent neurotoxin in…”
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The Amount of Scurfin Protein Determines Peripheral T Cell Number and Responsiveness by Khattri, Roli, Kasprowicz, Deborah, Cox, Tom, Mortrud, Marty, Appleby, Mark W, Brunkow, Mary E, Ziegler, Steven F, Ramsdell, Fred

“…In the absence of the recently identified putative transcription factor scurfin, mice develop a lymphoproliferative disorder resulting in death by 3 wk of age…”
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Molecular mechanisms of vertebrate left–right development by Ramsdell, Ann F, Yost, H.Joseph

“…Patterning of all tissues and organs in the vertebrate embryo occurs along the dorsoventral (DV), anteroposterior (AP), and left–right (LR) body axes. Whereas…”
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Foxp3 and Natural Regulatory T Cells: Key to a Cell Lineage? by Ramsdell, Fred

“…The recent characterization of a mutant strain of mice generated five decades ago in a program to study ionizing radiation in mammals (and, ironically, derived…”
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Positional Variations in Mammary Gland Development and Cancer by Veltmaat, Jacqueline M., Ramsdell, Ann F., Sterneck, Esta

“…Most mammals develop their mammary glands in pairs of which the two counterparts are symmetrically displaced away from the ventral midline. Based on this…”
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ALK4 functions as a receptor for multiple TGFβ-related ligands to regulate left–right axis determination and mesoderm induction in Xenopus by Chen, Yumei, Mironova, Ekaterina, Whitaker, Lisha L, Edwards, Laura, Yost, H.Joseph, Ramsdell, Ann F

“…In Xenopus, several TGFβs, including nodal-related 1 (Xnr1), derriere, and chimeric forms of Vg1, elicit cardiac and visceral organ left–right (LR) defects…”
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Intraductal Adaptation of the 4T1 Mouse Model of Breast Cancer Reveals Effects of the Epithelial Microenvironment on Tumor Progression and Metastasis by Atiya, Huda I, Dvorkin-Gheva, Anna, Hassell, John, Patel, Shrusti, Parker, Rachel L, Hartstone-Rose, Adam, Hodge, Johnie, Fan, Daping, Ramsdell, Ann F

“…Low success rates in oncology drug development are prompting re-evaluation of preclinical models, including orthotopic tumor engraftment. In breast cancer…”
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Inhibition of heart formation by lithium is an indirect result of the disruption of tissue organization within the embryo by Martin, Lisa K., Bratoeva, Momka, Mezentseva, Nadejda V., Bernanke, Jayne M., Remond, Mathieu C., Ramsdell, Ann F., Eisenberg, Carol A., Eisenberg, Leonard M.

“…Lithium is a commonly used drug for the treatment of bipolar disorder. At high doses, lithium becomes teratogenic, which is a property that has allowed this…”
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Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance by Ramsdell, Fred, Fowlkes, B. J.

“…During development in the thymus, T cells are rendered tolerant to self antigens. It is now apparent that thymocytes bearing self-reactive T cell receptors can…”
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Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway by Ramsdell, A F, Yost, H J

“…The rightward looping of the primary heart tube is dependent upon upstream patterning events that establish the vertebrate left-right axis. In Xenopus, a…”
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Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV‐1‐regulated protein gp34 by Baum, P.R., Gayle, R.B., Ramsdell, F., Srinivasan, S., Sorensen, R.A., Watson, M.L., Seldin, M.F., Baker, E., Sutherland, G.R., Clifford, K.N.

“…A ligand was cloned for murine OX40, a member of the TNF receptor family, using a T cell lymphoma cDNA library. The ligand (muOX40L) is a type II membrane…”
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Left–right analysis of mammary gland development in retinoid X receptor-α+/− mice by Robichaux, Jacqulyne P., Fuseler, John W., Patel, Shrusti S., Kubalak, Steven W., Hartstone-Rose, Adam, Ramsdell, Ann F.

“…Left–right (L–R) differences in mammographic parenchymal patterns are an early predictor of breast cancer risk; however, the basis for this asymmetry is…”
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