Search Results - "Ramsby, Melinda L."

Autoactivation profiles of calcium-dependent matrix metalloproteinase-2 and -9 in inflammatory synovial fluid: Effect of pyrophosphate and bisphosphonates by Makowski, Gregory S., Ramsby, Melinda L.

“…The presence of matrix metalloproteinase-2 and -9 (MMP-2, MMP-9), gelatinase A and B, in synovial fluid is typical in inflammatory connective tissue diseases…”
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Use of citrate to minimize neutrophil matrix metalloproteinase-9 in human plasma by Makowski, Gregory S., Ramsby, Melinda L.

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Zymographic analysis of latent and activated forms of matrix metalloproteinase-2 and -9 in synovial fluid: correlation to polymorphonuclear leukocyte infiltration and in response to infection by Makowski, Gregory S., Ramsby, Melinda L.

“…Background: Matrix metalloproteinase-2 and-9 (MMP-2, MMP-9), and gelatinase A and B participate in the degradation of the extracellular matrix proteins in a…”
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Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors by Ramsby, Melinda L.

“…The plasminogen activator/plasminogen activator inhibitor (PA/PAI) system is of considerable fundamental importance in elucidating the biochemical mechanisms…”
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Gelatinolytic and fibrinolytic activity in fresh-frozen plasma by Makowski, Gregory S, Ramsby, Melinda L

“…Fresh-frozen plasma (FFP) was evaluated for gelatinolytic and fibrinolytic activity. Gelatin zymography revealed that gelatinase A (MMP-2) was constitutively…”
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Selective detection of autoimmune antibodies to single- and double-stranded DNA by enzyme immunoassay by Makowski, Gregory S, Ramsby, Melinda L

“…Presence in serum of anti-double-stranded deoxyribonucleic acid antibodies (anti-dsDNA) is one of the diagnostic criteria for systemic lupus erythematosus…”
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An indium:calcium phosphate colloid that specifically targets fibrin by Makowski, Gregory S, Ramsby, Melinda L, Ramsby, Gale R

“…The ability of indium to target fibrin in vitro was evaluated. The radionuclide (114m)Indium (114mIn) was prepared as a soluble and colloidal (In:In) form, as…”
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Interaction of amorphous calcium phosphate with fibrin in vitro causes decreased fibrinolysis and altered protease profiles: implications for atherosclerotic disease by Makowski, G S, Ramsby, M L

“…Previously, we demonstrated that amorphous calcium phosphate (ACP), chemical precursor to apatite, strongly interacted with fibrin and facilitated binding of…”
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Ligneous conjunctivitis: biochemical evidence for hypofibrinolysis by Ramsby, M L, Donshik, P C, Makowski, G S

“…Ligneous conjunctivitis (LC) is a rare disease of unknown etiology characterized by the growth of "woody" plaques on ocular and extraocular mucosa. These…”
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Amorphous calcium phosphate-mediated binding of matrix metalloproteinase-9 to fibrin is inhibited by pyrophosphate and bisphosphonate by Makowski, G S, Ramsby, M L

“…Coordinate regulation of fibrinolytic and collagenolytic systems is essential for normal tissue remodeling and wound healing. To define the molecular…”
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Calibrating Gelatin Zymograms with Human Gelatinase Standards by Makowski, Gregory S., Ramsby, Melinda L.

“…We describe the use of gelatinase standards from human capillary whole blood for calibrating gelatin zymograms. Capillary blood was obtained by fingerstick…”
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Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells by Varghese, S, Ramsby, M L, Jeffrey, J J, Canalis, E

“…Basic fibroblast growth factor (bFGF) is a bone cell mitogen that affects osteoblastic function by suppressing type I collagen synthesis. The investigators in…”
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Binding of latent matrix metalloproteinase 9 to fibrin: activation via a plasmin-dependent pathway by Makowski, G S, Ramsby, M L

“…The binding of two matrix metalloproteinases (MMP) to fibrin was evaluated. MMP-2 (72-kDa) and MMP-9 (92-, 130-, and 225-kDa) were selected since both contain…”
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Identification and partial characterization of three calcium‐ and zinc‐independent gelatinases constitutively present in human circulation by Makowski, Gregory S., Ramsby, Melinda L.

“…Three constitutive gelatinases in human plasma were identified and characterized relative to known matrix metalloproteinase (MMP) gelatinases: MMP‐2…”
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pH modification to enhance the molecular sieving properties of sodium dodecyl sulfate-10% polyacrylamide gels by Makowski, G S, Ramsby, M L

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Binding of matrix metalloproteinase 9 to fibrin is mediated by amorphous calcium-phosphate by Makowski, G S, Ramsby, M L

“…In our previous study we demonstrated selective, dose-dependent binding of matrix metalloproteinase-9 (MMP-9), a neutrophil collagenase, to fibrin. Here we…”
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Degradation of cytokeratin intermediate filaments by calcium-activated proteases (calpains) in vitro: implications for formation of Mallory bodies by Makowski, G S, Ramsby, M L

“…The degradation of rat hepatic intermediate filament (IF) proteins cytokeratin A (CK-A, 55-kDa) and cytokeratin D (CK-D, 48-kDa) by purified rat liver…”
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Limited degradation of carbamoyl phosphate synthetase I by calcium-activated protease (calpain): electrophoretic evidence for removal of the C-terminal N-acetylglutamate regulatory domain by Makowski, G S, Ramsby, M L

“…The degradation of rat hepatic carbamoyl phosphate synthetase I (CPS) by calcium-activated thiol protease (calpain II) isolated from the same tissue was…”
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Identification and partial characterization of three calcium- and zinc-independent gelatinases constitutively present in human circulation by Makowski, G S, Ramsby, M L

“…Three constitutive gelatinases in human plasma were identified and characterized relative to known matrix metalloproteinase (MMP) gelatinases: MMP-2…”
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