Search Results - "Ramsay, R"

Methodology and reporting characteristics of studies using interrupted time series design in healthcare by Hudson, Jemma, Fielding, Shona, Ramsay, Craig R

“…Randomised controlled trials (RCTs) are considered the gold standard when evaluating the causal effects of healthcare interventions. When RCTs cannot be used…”
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Monoamine oxidases: the biochemistry of the proteins as targets in medicinal chemistry and drug discovery by Ramsay, Rona R

“…Monoamine oxidase (MAO, EC.1.4.3.4) has been a drug target for 60 years, with the primary rationale of developing drugs to treat neuropsychiatric disorders…”
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Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs by Ramsay, Rona R, Tipton, Keith F

“…The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of monoamine oxidases (MAO) and the cholinsterases (ChE) that have…”
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Inhibitor design for monoamine oxidases by Ramsay, Rona R

“…Flavin-containing monoamine oxidases (MAO A and MAO B) located on the outer membrane of mitochondria oxidise amines and generate hydrogen peroxide. Inhibitors…”
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Company–Community Agreements, Gender and Development by Keenan, J. C., Kemp, D. L., Ramsay, R. B.

“…Company–community agreements are widely considered to be a practical mechanism for recognising the rights, needs and priorities of peoples impacted by mining,…”
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Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open‐label, dose‐finding, phase 2 trial by Vaitkevicius, Henrikas, Ramsay, R. Eugene, Swisher, Christa B., Husain, Aatif M., Aimetti, Alex, Gasior, Maciej

“…Objective Patients with refractory status epilepticus (RSE) have failed treatment with benzodiazepines and ≥1 second‐line intravenous (IV) antiseizure…”
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A perspective on multi-target drug discovery and design for complex diseases by Ramsay, Rona R., Popovic-Nikolic, Marija R., Nikolic, Katarina, Uliassi, Elisa, Bolognesi, Maria Laura

“…Diseases of infection, of neurodegeneration (such as Alzheimer’s and Parkinson’s diseases), and of malignancy (cancers) have complex and varied causative…”
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Buna Joe "BJ" Wilder, MD (1929-2023) by Kalamangalam, Giridhar P, Ramsay, R E, Okun, Michael S

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The effects of on-screen, point of care computer reminders on processes and outcomes of care by Shojania, Kaveh G, Jennings, Alison, Mayhew, Alain, Ramsay, Craig R, Eccles, Martin P, Grimshaw, Jeremy

“…The opportunity to improve care by delivering decision support to clinicians at the point of care represents one of the main incentives for implementing…”
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Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction by Ramsay, R R, Dunford, C, Gillman, P K

“…Background and purpose: Monoamine oxidase inhibitors (MAOI) are known to cause serotonin toxicity (ST) when administered with selective serotonin reuptake…”
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Mapping the Structure and Metasomatic Enrichment of the Lithospheric Mantle Beneath the Kimberley Craton, Western Australia by Sudholz, Z. J., Jaques, A. L., Yaxley, G. M., Taylor, W. R., Czarnota, K., Haynes, M. W., Frewer, L., Ramsay, R. R., Downes, P. J., Cooper, S. A.

“…The lithology, geochemistry, and architecture of the continental lithospheric mantle (CLM) underlying the Kimberley Craton of north‐western Australia has been…”
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Predicting pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review by Ryan, J. E., Warrier, S. K., Lynch, A. C., Ramsay, R. G., Phillips, W. A., Heriot, A. G.

“…Aim Approximately 20% of patients treated with neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer achieve a pathological complete response…”
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One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug by Hughes, Rebecca E, Nikolic, Katarina, Ramsay, Rona R

“…HIGHLIGHTS Many AD target combinations are being explored for multi-target drug design.New databases and models increase the potential of computational drug…”
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An Audit and Feedback Intervention for Reducing Antibiotic Prescribing in General Dental Practice: The RAPiD Cluster Randomised Controlled Trial by Elouafkaoui, Paula, Young, Linda, Newlands, Rumana, Duncan, Eilidh M, Elders, Andrew, Clarkson, Jan E, Ramsay, Craig R

“…Dentists prescribe approximately 10% of antibiotics dispensed in UK community pharmacies. Despite clear clinical guidance, dentists often prescribe antibiotics…”
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A Randomized Trial Comparing Treatments for Varicose Veins by Brittenden, Julie, Cotton, Seonaidh C, Elders, Andrew, Ramsay, Craig R, Norrie, John, Burr, Jennifer, Campbell, Bruce, Bachoo, Paul, Chetter, Ian, Gough, Michael, Earnshaw, Jonothan, Lees, Tim, Scott, Julian, Baker, Sara A, Francis, Jill, Tassie, Emma, Scotland, Graham, Wileman, Samantha, Campbell, Marion K

“…This trial of varicose-vein treatments showed no substantial differences in quality of life 6 months after ultrasound-guided foam sclerotherapy, endovenous…”
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Five-Year Outcomes of a Randomized Trial of Treatments for Varicose Veins by Brittenden, Julie, Cooper, David, Dimitrova, Maria, Scotland, Graham, Cotton, Seonaidh C, Elders, Andrew, MacLennan, Graeme, Ramsay, Craig R, Norrie, John, Burr, Jennifer M, Campbell, Bruce, Bachoo, Paul, Chetter, Ian, Gough, Michael, Earnshaw, Jonothan, Lees, Tim, Scott, Julian, Baker, Sara A, Tassie, Emma, Francis, Jill, Campbell, Marion K

“…In a randomized trial, 798 patients with varicose veins were assigned to undergo laser ablation, foam sclerotherapy, or surgery. At 5 years, disease-specific…”
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New Insights on COX-2 in Chronic Inflammation Driving Breast Cancer Growth and Metastasis by Hugo, Honor J., Saunders, C., Ramsay, R. G., Thompson, E. W.

“…The medicinal use of aspirin stretches back to ancient times, before it was manufactured in its pure form in the late 19th century. Its accepted mechanistic…”
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New onset geriatric epilepsy : A randomized study of gabapentin, lamotrigine, and carbamazepine by ROWAN, A. J, RAMSAY, R. E, MARKS, W, FELICETTA, J, TOMYANOVICH, M. L, COLLINS, J. F, PRYOR, F, BOARDMAN, K. D, UTHMAN, B. M, SPITZ, M, FREDERICK, T, TOWNE, A, CARTER, G. S

“…To determine the relative tolerability and efficacy of two newer antiepileptic drugs, lamotrigine (LTG) and gabapentin (GBP), as compared to carbamazepine…”
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Prognostic factors influencing survival in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for isolated colorectal peritoneal metastases: a systematic review and meta‐analysis by Narasimhan, V., Tan, S., Kong, J., Pham, T., Michael, M., Ramsay, R., Warrier, S., Heriot, A.

“…Aim Peritoneal metastases from colorectal cancer confer the worst survival among all metastatic sites. The adoption of cytoreductive surgery (CRS) with…”
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Consensus on Outcome Measures for Glaucoma Effectiveness Trials: Results From a Delphi and Nominal Group Technique Approaches by Ismail, Rehab, Azuara-Blanco, Augusto, Ramsay, Craig R

“…Comparing the relative effectiveness of interventions across glaucoma trials can be problematic due to differences in definitions of outcomes. We sought to…”
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