Search Results - "Ramphal, John"

Total synthesis of trifluorobutyryl-modified, protected sialyl Lewis X by a convergent [2+2] approach by Akçay, Gizem, Ramphal, John Y., d’Alarcao, Marc, Kumar, Krishna

“…[Display omitted] Structural and quantitative changes in the expression of sialic acid residues on the surface of eukaryotic cells profoundly influence a broad…”
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Total synthesis of trifluorobutyryl-modified, globally protected sialyl Lewis x by a convergent [2+2] approach by Akçay, Gizem, Ramphal, John Y, d'Alarcao, Marc, Kumar, Krishna

“…Structural and quantitative changes in the expression of sialic acid residues on the surface of eukaryotic cells profoundly influence a broad range of…”
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Galactokinase 1 is the source of elevated galactose‐1‐phosphate and cerebrosides are modestly reduced in a mouse model of classic galactosemia by Mangini, Linley, Lawrence, Roger, Lopez, Manuel E., Graham, Timothy C., Bauer, Christopher R., Nguyen, Hang, Su, Cheng, Ramphal, John, Crawford, Brett E., Hartl, Tom A.

“…Classic galactosemia (CG) arises from loss‐of‐function mutations in the Galt gene, which codes for the enzyme galactose‐1‐phosphate uridylyltransferase (GALT),…”
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Structure-Based design and discovery of novel inhibitors of protein tyrosine phosphatases by Huang, Ping, Ramphal, John, Wei, James, Liang, Congxin, Jallal, Bahija, McMahon, Gerald, Tang, Cho

“…Protein tyrosine phosphatases (PTPs) are important in the regulation of signal transduction processes. Certain enzymes of this class are considered as…”
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Structure-Activity Relationships of Sialyl Lewis x-Containing Oligosaccharides. 1. Effect of Modifications of the Fucose Moiety by Ramphal, John Y, Zheng, Zhong-Li, Perez, Carl, Walker, Leslie E, DeFrees, Shawn A, Gaeta, Federico C. A

“…Leukocyte adhesion to the vasculature is mediated by E-, P-, and L-selectins. The natural ligands for E- and P-selectins have not been fully characterized but…”
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Ligand Interactions with E-Selectin. Identification of a New Binding Site for Recognition of N-Acyl Aromatic Glucosamine Substituents of Sialyl Lewis X by Ramphal, John Y, Hiroshige, Mariann, Lou, Boliang, Gaudino, John J, Hayashi, Masaji, Chen, Shiow Meei, Chiang, Lin C, Gaeta, Federico C. A, DeFrees, Shawn A

“…Several N-acylglucosamine derivatives of sialyl Lewis X (1−3) were prepared using a combined chemical enzymatic approach and evaluated as an inhibitor of…”
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A selective small molecule inhibitor of c-Met kinase inhibits c-met-dependent phenotypes in vitro and exhibits cytoreductive antitumor activity in vivo by CHRISTENSEN, James G, SCHRECK, Randall, LIPSON, Kenneth E, RAMPHAL, John, DO, Steven, CUI, Jingrong J, CHERRINGTON, Julie M, MENDEL, Dirk B, BURROWS, Jon, KURUGANTI, Poonam, CHAN, Emily, PHUONG LE, CHEN, Jeffrey, XUEYAN WANG, RUSLIM, Lany, BLAKE, Robert

“…The c-Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), have been implicated in the development and progression of several human…”
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Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor1 (CRF1) receptor antagonists by HUANG, Charles Q, GRIGORIADIS, Dimitri E, ZHENGYU LIU, MCCARTHY, James R, RAMPHAL, John, WEBB, Thomas, WHITTEN, Jeffrey P, XIE, Michael Y, CHEN CHEN

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Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor(1) (CRF(1)) receptor antagonists by Huang, Charles Q, Grigoriadis, Dimitri E, Liu, Zhengyu, McCarthy, James R, Ramphal, John, Webb, Thomas, Whitten, Jeffrey P, Xie, Michael Y, Chen, Chen

“…A series of 2-dialkylamino-4-phenylpyrimidines (7) was designed and synthesized as CRF(1) antagonists. SAR studies of this series resulted in the discovery of…”
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Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor 1 (CRF 1 ) receptor antagonists by Huang, Charles Q, Grigoriadis, Dimitri E, Liu, Zhengyu, McCarthy, James R, Ramphal, John, Webb, Thomas, Whitten, Jeffrey P, Xie, Michael Y, Chen, Chen

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V. S. Naipaul's vision of Third World countries by Ramphal, John Kuar Persaud

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The Reactions of o-Quinone Monoimides with Some Thiophenes and Furans by W. Heine, Harold, K. Williams, David, L. Rutherford, Jennifer, Ramphal, John, A. Williams, Elizabeth

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