Search Results - "Rampa, A."

Design of multifunctional compounds for cardiovascular disease: from natural scaffolds to "classical" multitarget approach by Bisi, A, Gobbi, S, Belluti, F, Rampa, A

“…Cardiovascular disease represents the main cause of death worldwide. Novel therapies to reduce elevated blood pressure and treat resistant hypertension, to…”
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A New Class of Nonsteroidal Aromatase Inhibitors:  Design and Synthesis of Chromone and Xanthone Derivatives and Inhibition of the P450 Enzymes Aromatase and 17α-Hydroxylase/C17,20-Lyase by Recanatini, Maurizio, Bisi, Alessandra, Cavalli, Andrea, Belluti, Federica, Gobbi, Silvia, Rampa, Angela, Valenti, Piero, Palzer, Martina, Palusczak, Anja, Hartmann, Rolf W

“…Aromatase (P450arom) is a target of pharmacological interest for the treatment of breast cancer. In this paper, we report the design, synthesis, and in vitro…”
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La cerámica de Pichanal 4. Un puesto pastoril Tardío de la Sierra del Cajón (Provincia de Catamarca) by Daniel A. Rampa

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Coumarin 1,4-Dihydropyridine Derivatives by Valenti, P., Rampa, A., Budriesi, R., Bisi, A., Chiarini, A.

“…A series of 1,4-dihydropyridines bearing a coumarin moiety in 4-position was synthesized. The compounds were evaluated for inotropic, chronotropic and calcium…”
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Cardiovascular Profile of Xanthone-Based 1,4 Dihydropyridines Bearing a Lidoflazine Pharmacophore Fragment by Bisi, Alessandra, Micucci, Matteo, Gobbi, Silvia, Belluti, Federica, Budriesi, Roberta, Rampa, Angela

“…As a follow-up to our previous studies on differently substituted 1,4-dihydropyridines endowed with a peculiar cardiac selectivity, in this paper, a small…”
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3-(4-{[Benzyl(methyl)amino]methyl}phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) Inhibits Both Acetylcholinesterase and Acetylcholinesterase-Induced β-Amyloid Aggregation:  A Dual Function Lead for Alzheimer's Disease Therapy by Piazzi, Lorna, Rampa, Angela, Bisi, Alessandra, Gobbi, Silvia, Belluti, Federica, Cavalli, Andrea, Bartolini, Manuela, Andrisano, Vincenza, Valenti, Piero, Recanatini, Maurizio

“…In recent years, the investigation of acetylcholinesterase (AChE) inhibitors has gained further interest, because the involvement of the peripheral site of the…”
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1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine by Chiarini, A., Rampa, A., Budriesi, R., Bisi, A., Fabbri, G., Valenti, P.

“…A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic,…”
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Cholinesterase Inhibitors:  Xanthostigmine Derivatives Blocking the Acetylcholinesterase-Induced β-Amyloid Aggregation by Belluti, Federica, Rampa, Angela, Piazzi, Lorna, Bisi, Alessandra, Gobbi, Silvia, Bartolini, Manuela, Andrisano, Vincenza, Cavalli, Andrea, Recanatini, Maurizio, Valenti, Piero

“…In continuing research that led us to identify a new class of carbamate derivatives acting as potent (Rampa et al. J. Med. Chem. 1998, 41, 3976) and…”
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Synthesis of a series of Homopterocarpane derivatives with potential antitumor and anti-AIDS activity by Valenti, P, Fabbri, G, Rampa, A, Bisi, A, Belluti, F

“…The synthesis of a series of derivatives related to (+/-) cis 6a, 12a-dihydro-6H,7H-[1]-benzopyrano-[4,3-b]-[1]-benzopyran (Homopterocarpane) is described. The…”
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Enantioselective Nonsteroidal Aromatase Inhibitors Identified through a Multidisciplinary Medicinal Chemistry Approach by Cavalli, Andrea, Bisi, Alessandra, Bertucci, Carlo, Rosini, Carlo, Paluszcak, Anja, Gobbi, Silvia, Giorgio, Egidio, Rampa, Angela, Belluti, Federica, Piazzi, Lorna, Valenti, Piero, Hartmann, Rolf W, Recanatini, Maurizio

“…To identify enantioselective nonsteroidal aromatase inhibitors, a multidisciplinary medicinal chemistry approach was pursued. First, our earlier CoMFA model…”
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Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells by Valenti, P, Da Re, P, Rampa, A, Montanari, P, Carrara, M, Cima, L

“…Chromone, flavone and xanthone analogues of geiparvarin (1) are described. Compounds 2a and 2b are more active in inhibiting the proliferation of F10…”
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SAR of 9-Amino-1,2,3,4-tetrahydroacridine-Based Acetylcholinesterase Inhibitors:  Synthesis, Enzyme Inhibitory Activity, QSAR, and Structure-Based CoMFA of Tacrine Analogues by Recanatini, Maurizio, Cavalli, Andrea, Belluti, Federica, Piazzi, Lorna, Rampa, Angela, Bisi, Alessandra, Gobbi, Silvia, Valenti, Piero, Andrisano, Vincenza, Bartolini, Manuela, Cavrini, Vanni

“…In this study, we attempted to derive a comprehensive SAR picture for the class of acetylcholinesterase (AChE) inhibitors related to tacrine, a drug currently…”
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1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety by Budriesi, Roberta, Bisi, Alessandra, Ioan, Pierfranco, Rampa, Angela, Gobbi, Silvia, Belluti, Federica, Piazzi, Lorna, Valenti, Piero, Chiarini, Alberto

“…The synthesis and negative chronotropic activity of 1,4-dihydropyridine derivative 3b (EC 30 = 9.7 nM) is reported. It was earlier recognized that calcium…”
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SAR studies in the field of Ca-antagonists: 2-substituted 1,4-dihydropyridines with a xanthone backbone by Bisi, A, Budriesi, R, Chiarini, A, Rampa, A, Valenti, P

“…A series of 2-substituted 1,4-dihydropyridines with a xanthone backbone was prepared. The compounds were evaluated for inotropic, chronotropic and calcium…”
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Synthesis and Biological Evaluation of 3-Alkoxy Analogues of Flavone-8-acetic Acid by Gobbi, Silvia, Rampa, Angela, Bisi, Alessandra, Belluti, Federica, Piazzi, Lorna, Valenti, Piero, Caputo, Anna, Zampiron, Antonella, Carrara, Maria

“…New analogues of flavone-8-acetic acid were synthesized, bearing an alkoxy group in position 3 and different substituents on the benzene ring in position 2 of…”
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Acetylcholinesterase inhibitors for potential use in Alzheimer's disease : Molecular modeling, synthesis and kinetic evaluation of 11H-indeno-[1,2-b]-quinolin-10-ylamine derivatives by RAMPA, A, BISI, A, BELLUTI, F, GOBBI, S, VALENTI, P, ANDRISANO, V, CAVRINI, V, CAVALLI, A, RECANATINI, M

“…Continuing our work on tetracyclic tacrine analogues, we synthesized a series of acetylcholinesterase (AChE) inhibitors of…”
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Acetylcholinesterase Inhibitors:  SAR and Kinetic Studies on ω-[N-Methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl Derivatives by Rampa, Angela, Piazzi, Lorna, Belluti, Federica, Gobbi, Silvia, Bisi, Alessandra, Bartolini, Manuela, Andrisano, Vincenza, Cavrini, Vanni, Cavalli, Andrea, Recanatini, Maurizio, Valenti, Piero

“…In this work, we further investigated a class of carbamic cholinesterase inhibitors introduced in a previous paper (Rampa et al. J. Med. Chem. 1998, 41, 3976)…”
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Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid by VALENTI, P, BISI, A, RAMPA, A, BELLUTI, F, GOBBI, S, ZAMPIRON, A, CARRARA, M

“…Some rigid analogues of flavone-8-acetic acid are described. Direct in vitro toxicity of the synthesised compounds was evaluated towards four tumoral cell…”
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Cytotoxicity of simple geiparvarin analogues by Carrara, M, Cima, L, Valenti, P, Rampa, A, Da Re, P, Recanatini, M

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Some new prazosin-like derivatives by Rampa, A, Carrara, M, Zampiron, S

“…The preparation of a number of prazosin-like derivatives is reported. The new derivatives differ from the parent compound for the 2-side-chain which is…”
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