Search Results - "Ramos‐Fernandez, Eva"

Modification of γ‐secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease by Guix, Francesc X., Wahle, Tina, Vennekens, Kristel, Snellinx, An, Chávez‐Gutiérrez, Lucía, Ill‐Raga, Gerard, Ramos‐Fernandez, Eva, Guardia‐Laguarta, Cristina, Lleó, Alberto, Arimon, Muriel, Berezovska, Oksana, Muñoz, Francisco J., Dotti, Carlos G., De Strooper, Bart

“…Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid…”
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Astrocytic release of ATP through type 2 inositol 1,4,5‐trisphosphate receptor calcium signaling and social dominance behavior in mice by Guillot de Suduiraut, Isabelle, Grosse, Jocelyn, Ramos‐Fernández, Eva, Sandi, Carmen, Hollis, Fiona

“…Brain mitochondrial function is critical for numerous neuronal processes. We recently identified a link between brain energy and social dominance, where higher…”
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The blood-brain barrier: structure, function and therapeutic approaches to cross it by Tajes, Marta, Ramos-Fernández, Eva, Weng-Jiang, Xian, Bosch-Morató, Mònica, Guivernau, Biuse, Eraso-Pichot, Abel, Salvador, Bertrán, Fernàndez-Busquets, Xavier, Roquer, Jaume, Muñoz, Francisco J

“…The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that interacts directly with astrocytes, neurons and pericytes. It protects…”
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Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling by Ramos-Fernández, Eva, Tapia-Rojas, Cheril, Ramírez, Valerie T., Inestrosa, Nibaldo C.

“…Wnt signaling regulates brain development and synapse maturation; however, the precise molecular mechanism remains elusive. Here, we report that Wnt-7a…”
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Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function by Ghosal, Sriparna, Gebara, Elias, Ramos-Fernández, Eva, Chioino, Alessandro, Grosse, Jocelyn, Guillot de Suduiraut, Isabelle, Zanoletti, Olivia, Schneider, Bernard, Zorzano, Antonio, Astori, Simone, Sandi, Carmen

“…The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety…”
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Wnt Signaling Prevents the Aβ Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons by Arrázola, Macarena S, Ramos-Fernández, Eva, Cisternas, Pedro, Ordenes, Daniela, Inestrosa, Nibaldo C

“…Alzheimer's disease (AD) is a neurodegenerative disorder mainly known for synaptic impairment and neuronal cell loss, affecting memory processes. Beside these…”
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Wnt5a promotes hippocampal postsynaptic development and GluN2B-induced expression via the eIF2α HRI kinase by Ramos-Fernández, Eva, Arrázola, Macarena S., Oliva, Carolina A., Arredondo, Sebastián B., Varela-Nallar, Lorena, Inestrosa, Nibaldo C.

“…Wnt signaling plays a key role in neurodevelopment and neuronal maturation. Specifically, Wnt5a stimulates postsynaptic assemblies, increases glutamatergic…”
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Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort by Zalachoras, Ioannis, Ramos-Fernández, Eva, Hollis, Fiona, Trovo, Laura, Rodrigues, João, Strasser, Alina, Zanoletti, Olivia, Steiner, Pascal, Preitner, Nicolas, Xin, Lijing, Astori, Simone, Sandi, Carmen

“…Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to…”
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Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis by Ill-Raga, Gerard, Tajes, Marta, Busquets-García, Arnau, Ramos-Fernández, Eva, Vargas, Lina M, Bosch-Morató, Mònica, Guivernau, Biuse, Valls-Comamala, Victòria, Eraso-Pichot, Abel, Guix, Francesc X, Fandos, César, Rosen, Mark D, Rabinowitz, Michael H, Maldonado, Rafael, Alvarez, Alejandra R, Ozaita, Andrés, Muñoz, Francisco J

“…Hippocampus is the brain center for memory formation, a process that requires synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's…”
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Fibrinogen nitrotyrosination after ischemic stroke impairs thrombolysis and promotes neuronal death by ILL-Raga, Gerard, Palomer, Ernest, Ramos-Fernández, Eva, Guix, Francesc X., Bosch-Morató, Mònica, Guivernau, Biuse, Tajes, Marta, Valls-Comamala, Victòria, Jiménez-Conde, Jordi, Ois, Angel, Pérez-Asensio, Fernando, Reyes-Navarro, Mario, Caballo, Carolina, Gil-Gómez, Gabriel, Lopez-Vilchez, Irene, Galan, Ana M., Alameda, Francesc, Escolar, Gines, Opazo, Carlos, Planas, Anna M., Roquer, Jaume, Valverde, Miguel A., Muñoz, Francisco J.

“…Ischemic stroke is an acute vascular event that compromises neuronal viability, and identification of the pathophysiological mechanisms is critical for its…”
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Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation by Ramos-Fernández, Eva, Tajes, Marta, Palomer, Ernest, Ill-Raga, Gerard, Bosch-Morató, Mònica, Guivernau, Biuse, Román-Dégano, Irene, Eraso-Pichot, Abel, Alcolea, Daniel, Fortea, Juan, Nuñez, Laura, Paez, Antonio, Alameda, Francesc, Fernández-Busquets, Xavier, Lleó, Alberto, Elosúa, Roberto, Boada, Mercé, Valverde, Miguel A, Muñoz, Francisco J

“…Glycation and nitrotyrosination are pathological posttranslational modifications that make proteins prone to losing their physiological properties. Since both…”
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Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease by Tajes, Marta, Eraso-Pichot, Abel, Rubio-Moscardó, Fanny, Guivernau, Biuse, Ramos-Fernández, Eva, Bosch-Morató, Mònica, Guix, Francesc Xavier, Clarimón, Jordi, Miscione, Gian Pietro, Boada, Mercé, Gil-Gómez, Gabriel, Suzuki, Toshiharu, Molina, Henrik, Villà-Freixa, Jordi, Vicente, Rubén, Muñoz, Francisco J

“…Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of…”
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Glutamatergic stimulation induces GluN2B translation by the nitric oxide-Heme-Regulated eIF2α kinase in cortical neurons by Ramos-Fernández, Eva, Tajes, Marta, Ill-Raga, Gerard, Vargas, Lina, Busquets-García, Arnau, Bosch-Morató, Mònica, Guivernau, Biuse, Valls-Comamala, Victòria, Gomis, Maria, Grau, Cristina, Fandos, César, Rosen, Mark D, Rabinowitz, Michael H, Inestrosa, Nibaldo, Maldonado, Rafael, Altafaj, Xavier, Ozaita, Andrés, Alvarez, Alejandra, Vicente, Rubén, Valverde, Miguel A, Muñoz, Francisco J

“…The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is…”
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Nitro-Oxidative Stress after Neuronal Ischemia Induces Protein Nitrotyrosination and Cell Death by Bosch-Morató, Mònica, Guix, Francesc X., Ramos-Fernández, Eva, Palomer, Ernest, ILL-Raga, Gerard, Tajes, Marta, Guivernau, Biuse, Jiménez-Conde, Jordi, Ois, Angel, Pérez-Asensio, Fernando, Reyes-Navarro, Mario, Caballo, Carolina, Galán, Ana M., Alameda, Francesc, Escolar, Ginés, Opazo, Carlos, Planas, Anna, Roquer, Jaume, Valverde, Miguel A., Muñoz, Francisco J.

“…Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and…”
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Therapeutic potential of glutathione-enhancers in stress-related psychopathologies by Zalachoras, Ioannis, Hollis, Fiona, Ramos-Fernández, Eva, Trovo, Laura, Sonnay, Sarah, Geiser, Eveline, Preitner, Nicolas, Steiner, Pascal, Sandi, Carmen, Morató, Laia

“…[Display omitted] •Mitochondria meet the high energetic demand of the brain during psychogenic stress.•Chronic stress leads to oxidative stress and lower…”
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Modulation of the NMDA Receptor Through Secreted Soluble Factors by Cerpa, Waldo, Ramos-Fernández, Eva, Inestrosa, Nibaldo C.

“…Synaptic activity is a critical determinant in the formation and development of excitatory synapses in the central nervous system (CNS). The excitatory current…”
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Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency by De La Rossa, Andres, Laporte, Marine H, Astori, Simone, Marissal, Thomas, Montessuit, Sylvie, Sheshadri, Preethi, Ramos-Fernández, Eva, Mendez, Pablo, Khani, Abbas, Quairiaux, Charles, Taylor, Eric B, Rutter, Jared, Nunes, José Manuel, Carleton, Alan, Duchen, Michael R, Sandi, Carmen, Martinou, Jean-Claude

“…Neuronal excitation imposes a high demand of ATP in neurons. Most of the ATP derives primarily from pyruvate-mediated oxidative phosphorylation, a process that…”
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Wnt Signaling Prevents the A[beta] Oligomer-Induced Mitochondrial Permeability Transition Pore Opening Preserving Mitochondrial Structure in Hippocampal Neurons by Arrázola, Macarena S, Ramos-Fernández, Eva, Cisternas, Pedro, Ordenes, Daniela, Inestrosa, Nibaldo C

“…Alzheimer's disease (AD) is a neurodegenerative disorder mainly known for synaptic impairment and neuronal cell loss, affecting memory processes. Beside these…”
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Activation of PKR causes amyloid beta-peptide accumulation via De-Repression of Bace1 expression by Ill-Raga, Gerard, 1982, Palomer, Ernest, Wozniak, Matthew A, Ramos Fernández, Eva, 1984, Bosch Morató, Mònica, 1986, Tajes Orduña, Marta, Guix Ràfols, Francesc Xavier, Galán, José J, Clarimón Echevarría, Jordi, Antúnez, Carmen, Real, Luis M, Boada, Mercè, Itzhaki, Ruth F, Fandos, César, Muñoz López, Francisco José, 1964

“…BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively…”
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Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression by Ill-Raga, Gerard, Palomer, Ernest, Wozniak, Matthew A, Ramos-Fernández, Eva, Bosch-Morató, Mònica, Tajes, Marta, Guix, Francesc X, Galán, José J, Clarimón, Jordi, Antúnez, Carmen, Real, Luis M, Boada, Mercé, Itzhaki, Ruth F, Fandos, César, Muñoz, Francisco J

“…BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively…”
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