Search Results - "Ramos‐Bermúdez, Pablo E."

A hydrolyzed N‐propionylthiosuccinimide linker is cleaved by metastable fragmentation, increasing reliability of conjugation site identification in conjugate vaccines by Ramos‐Bermúdez, Pablo E., Pousa, Satomy, Carvalho, Paulo, Brant, Rodrigo Soares Caldeira, Batista, Michel, Hojo, Hironobu, Garay, Hilda E., Roscoe, Abel, Mallón, Alina Rodríguez, Besada, Vladimir, Takao, Toshifumi, González, Luis Javier

“…RATIONALE Conjugation sites are a quality attribute of conjugate vaccines. Proteolysis of bioconjugates synthesized by maleimide–thiol chemistry generates type…”
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On the utility of the extracted ion chromatograms for assigning the conjugation sites and side reactions in bioconjugates synthesized by the maleimide-thiol chemistry by Pousa, Satomy, Ramos-Bermúdez, Pablo E., Besada, Vladimir, Carvalho, Paulo, Ulrich, Louise Kurt, Batista, Michel, Brant, Rodrigo Soares Caldeira, Martínez, Olivia, Leyva, Alejandro, Durán, Rosario, Murillo, Dhayme, Fajardo, Abel, Garay, Hilda Elisa, Rodríguez-Mallón, Alina, Takao, Toshifumi, González, Luis Javier

“…[Display omitted] •Sample processing transforms the thiosuccinimide linker into its stabilized forms.•Isobaric species of the stabilized linker are separated…”
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