Antibacterial and cytotoxic properties of some plant crude extracts used in Northeastern folk medicine

Antibacterial and cytotoxic properties of some plant crude extracts used in Northeastern folk medicine

In the present study, 32 hexane and ethanol extracts of Protium bahianum, P. heptaphyllum, Croton sellowii, C. rhamnifolius, C. jacobinensis, C. micans and Muntingia calabura were screened for antibacterial activity by the disc-diffusion method. Cytotoxicity assays using the brine shrimp Artemia sal...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia Vol. 19; no. 2a; pp. 376 - 381
Main Authors: Ramos, Suzana C. S., Oliveira, José C. S. de, Câmara, Cláudio A. G. da, Castelar, Ivan, Carvalho, Ana F. F. U., Lima-Filho, José V.
Format: Journal Article
Language:English
Published: Sociedade Brasileira de Farmacognosia 01-06-2009
Subjects:
PHARMACOLOGY & PHARMACY
antibacterial activity
citotoxicidade
Artemia salina
Muntingia calabura
Protium
atividade antibacteriana
Croton
cytotoxicity
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Summary:In the present study, 32 hexane and ethanol extracts of Protium bahianum, P. heptaphyllum, Croton sellowii, C. rhamnifolius, C. jacobinensis, C. micans and Muntingia calabura were screened for antibacterial activity by the disc-diffusion method. Cytotoxicity assays using the brine shrimp Artemia salina Leach as a model were performed to determine lethal doses for 50% of individuals (LC50 µg/mL). Antibacterial activity was found in flowers hexane extracts of M. calabura against B. subtilis, and leaves ethanol extracts against S. aureus and B. subtilis at concentration of 1mg/mL. Among 32 extracts, 19 showed low or no toxicity (LC50 > 250 µg/mL), 6 showed moderate toxicity (LC50 between 80 µg/mL and 250µg/mL), and 7 were highly toxic (LC50 < 80 µg/mL).
ISSN:0102-695X
1981-528X
0102-695X
DOI:10.1590/S0102-695X2009000300007