Efficacy of monthly treatment with oral fluralaner (Bravecto ® 1-Month) against Tunga penetrans in dogs in Brazil: a randomized, double-blind, controlled field study

Tungiasis is a neglected tropical disease caused by the adult female sand flea (Tunga penetrans). Dogs are considered important reservoirs of T. penetrans in Brazil. The aim of this study was to determine the monthly insecticidal efficacy of a single oral administration of fluralaner at a dose of 10...

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Published in:	Parasites & vectors Vol. 17; no. 1; p. 197
Main Authors:	Dos Santos, Katharine Costa, Guedes, Paula Elisa Brandão, Albuquerque, George Rêgo, de Jesus, Anderson Vieira, da Paixão Sevá, Anaiá, de Oliveira, Joana Thaisa Santos, de Carvalho Teixeira, Jamille Bispo, Bitar, Thammy Vieira, Harvey, Tatiani Vitor, Ramos, Sofia Nadir Sanches, Barufi, Francisco Bonomi, de Almeida Borges, Fernando, Carlos, Renata Santiago Alberto
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 29-04-2024 BioMed Central BMC
Subjects:	Administration, Oral Animals Brazil Canine tungiasis Dog Diseases - drug therapy Dog Diseases - parasitology Dogs Double-Blind Method Ectoparasitosis Female Health aspects Insecticides - administration & dosage Insecticides - therapeutic use Isoxazoles - administration & dosage Isoxazoles - therapeutic use Male Rural communities Treatment Treatment Outcome Tunga - drug effects Tungiasis - drug therapy Tungiasis - parasitology Tungiasis - veterinary Zoonosis Brazil Canine tungiasis Treatment Zoonosis Rural communities Ectoparasitosis
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Summary:	Tungiasis is a neglected tropical disease caused by the adult female sand flea (Tunga penetrans). Dogs are considered important reservoirs of T. penetrans in Brazil. The aim of this study was to determine the monthly insecticidal efficacy of a single oral administration of fluralaner at a dose of 10-18 mg/kg (Bravecto 1-Month, also registered as Defenza in some countries; MSD Animal Health) in dogs naturally infested with T. penetrans. This clinical trial was conducted in a rural community located in Ilhéus, Bahia, Brazil. A total of 64 dogs were selected and distributed in a completely randomized design between a treated group (TG) that received one single dose of Bravecto 1-Month (Defenza ) and a negative control group (CG) that received no treatment. Each group was composed of 32 dogs. The evaluations took place on days 0, 7 ± 2, 14 ± 2, 21 ± 2, 28 ± 2, 35 ± 2, and 42 ± 2 post treatment, in which the dogs were inspected to evaluate the infestation stage and classify lesions associated with tungiasis. The primary efficacy was determined from the percentage of treated dogs free of fleas (stage II and III lesions) after administration of the formulation at each evaluation time. Secondary efficacy was based on the number of active lesions (stages II and III) in each group at each evaluation time. The clinical condition of the animals was defined based on the Severity Score for Acute Dog Tungiasis (SCADT), which is related to the number and severity of lesions. The primary efficacy of the product was greater than 95.0% from days 7 to 21 and reached 100.0% between days 28 and 42, with a significant association between treatment and infestation decline (P < 0.025) between days 7 and 42. Secondary drug efficacy was greater than 99.9% from days 7 to 21, reaching 100.0% between days 28 and 42 (P < 0.05). The treated dogs also scored lower on the SCADT than the control animals did during the entire clinical evaluation period (P < 0.05). A single administration of Bravecto 1-Month (Defenza ) was effective in eliminating Tunga penetrans infestations, as well as in preventing parasitism for at least 42 days after treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1756-3305 1756-3305
DOI:	10.1186/s13071-024-06272-y