Search Results - "Ramos, Ryan"
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Identification of Potential COX-2 Inhibitors for the Treatment of Inflammatory Diseases Using Molecular Modeling Approaches
Published in Molecules (Basel, Switzerland) (12-09-2020)“…Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed in order to avoid the side effects of non-selective…”
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Ergostanes from the mushroom Trametes versicolor and their cancer cell inhibition: In vitro and in silico evaluation
Published in Steroids (01-12-2024)“…[Display omitted] In this study, five steroid compounds were isolated from the fruiting bodies mushroom Trametes versicolor. The compounds,…”
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Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach
Published in International journal of molecular sciences (01-09-2022)“…Aedes aegypti mosquitoes transmit several human pathogens that cause millions of deaths worldwide, mainly in Latin America. The indiscriminate use of…”
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Hierarchical Virtual Screening and Binding Free Energy Prediction of Potential Modulators of Aedes Aegypti Odorant-Binding Protein 1
Published in Molecules (Basel, Switzerland) (01-10-2022)“…The Aedes aegypti mosquito is the main hematophagous vector responsible for arbovirus transmission in Brazil. The disruption of A. aegypti hematophagy remains…”
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Association of six-minute walk test distance with postoperative complications in non-cardiac surgery: a secondary analysis of a multicentre prospective cohort study
Published in Canadian journal of anesthesia (01-04-2021)“…Purpose The six-minute walk test (6MWT) is a simple and valid test for assessing cardiopulmonary fitness. Nevertheless, the relationship between preoperative…”
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6
Larvicidal activity against Aedes aegypti and molecular docking studies of compounds extracted from the endophytic fungus Aspergillus sp. isolated from Bertholletia excelsa Humn. & Bonpl
Published in Biotechnology letters (01-03-2022)“…Endophytic fungi are microorganisms capable of colonizing the interior of plant tissues without causing damage to them. The study of the secondary metabolites…”
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Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2
Published in International journal of molecular sciences (04-02-2022)“…This study aimed to identify potential inhibitors and investigate the mechanism of action on SARS-CoV-2 ACE2 receptors using a molecular modeling study and…”
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Identification of Novel Chemical Entities for Adenosine Receptor Type 2A Using Molecular Modeling Approaches
Published in Molecules (Basel, Switzerland) (10-03-2020)“…Adenosine Receptor Type 2A (A AR) plays a role in important processes, such as anti-inflammatory ones. In this way, the present work aimed to search for…”
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9
Design and Identification of Inhibitors for the Spike-ACE2 Target of SARS-CoV-2
Published in International journal of molecular sciences (16-05-2023)“…When an epidemic started in the Chinese city of Wuhan in December 2019, coronavirus was identified as the cause. Infection by the virus occurs through the…”
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10
Versatile Applications of Cyanoacetic Acid in Organic Chemistry: Active Methylene Compound for the Knoevenagel Condensation and Organocatalyst for the Biginelli Reaction
Published in Journal of the Brazilian Chemical Society (2024)“…The application of cyanoacetic acid as a catalyst for the Biginelli reaction and as an active methylene compound for the Knoevenagel condensation reaction was…”
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Potential inhibitors of the enzyme acetylcholinesterase and juvenile hormone with insecticidal activity: study of the binding mode via docking and molecular dynamics simulations
Published in Journal of biomolecular structure & dynamics (01-11-2020)“…Models validation in QSAR, pharmacophore, docking and others can ensure the accuracy and reliability of future predictions in design and selection of molecules…”
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Rational Approach toward COVID-19's Main Protease Inhibitors: A Hierarchical Biochemoinformatics Analysis
Published in International journal of molecular sciences (18-06-2024)“…This study investigated the potential of selected compounds as inhibitors of SARS-CoV-2 M through pharmacokinetic and toxicological analyses, molecular…”
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Chemical Composition, an Antioxidant, Cytotoxic and Microbiological Activity of the Essential Oil from the Leaves of Aeollanthus suaveolens Mart. ex Spreng
Published in PloS one (01-12-2016)“…Aeollanthus suaveolens species popularly known as catinga de mulata belongs to the Lamiaceae family. In the Amazon region, it is used in folk medicine for the…”
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14
Natural Products Diversity from Genus Aspergillus: A Bioinformatics Study for Insecticidal Activity against the Aedes aegypti Vector
Published in Journal of the Brazilian Chemical Society (2025)“…Computational predictive approaches present themselves as an attractive alternative in the search for new compounds that may present toxic or growth regulatory…”
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15
Acute Toxicity and Anti-Inflammatory Activity of Trattinnickia rhoifolia Willd (Sucuruba) Using the Zebrafish Model
Published in Molecules (Basel, Switzerland) (10-11-2022)“…The species Trattinnickia rhoifolia Willd, (T. rhoifolia), which belongs to the Burseraceae family, is widely used in ethnopharmacological cultural practices…”
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Oil from the fruits of Pterodon emarginatus Vog.: A traditional anti-inflammatory. Study combining in vivo and in silico
Published in Journal of ethnopharmacology (10-08-2018)“…The oil obtained from the fruits of Pterodon emarginatus Vog. (OPe) is used orally and topically, in traditional medicine for some purposes, such as acute and…”
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An In Silico Study of the Antioxidant Ability for Two Caffeine Analogs Using Molecular Docking and Quantum Chemical Methods
Published in Molecules (Basel, Switzerland) (29-10-2018)“…The antioxidant activity of molecules constitutes an important factor for the regulation of redox homeostasis and reduction of the oxidative stress. Cells…”
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18
Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism
Published in Molecules (Basel, Switzerland) (01-01-2019)“…A drug design for safer phenylbutazone was been explored by reactivity and docking studies involving single electron transfer mechanism, as well as…”
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An Antioxidant Potential, Quantum-Chemical and Molecular Docking Study of the Major Chemical Constituents Present in the Leaves of Curatella americana Linn
Published in Pharmaceuticals (Basel, Switzerland) (20-07-2018)“…Reactive oxygen species (ROS) are continuously generated in the normal biological systems, primarily by enzymes as xanthine oxidase (XO). The inappropriate…”
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Hierarchical Virtual Screening of Potential New Antibiotics from Polyoxygenated Dibenzofurans against Staphylococcus aureus Strains
Published in Pharmaceuticals (Basel, Switzerland) (09-10-2023)“…Staphylococcus aureus is a microorganism with high morbidity and mortality due to antibiotic-resistant strains, making the search for new therapeutic options…”
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