Search Results - "Ramos, Priscila Z."
-
1
Relationship Between Patients with Clinical Auditory Neuropathy Spectrum Disorder and Mutations in Gjb2 Gene
Published in The open neurology journal (30-09-2016)“…The auditory neuropathy is a condition which there is a dyssynchrony in the nerve conduction of the auditory nerve fibers. There is no evidence about the…”
Get full text
Journal Article -
2
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors
Published in Bioorganic & medicinal chemistry (15-01-2024)“…The dual-specificity protein kinase MKK3 has been implicated in tumor cell proliferation and survival, yet its precise role in cancer remains inconclusive. A…”
Get full text
Journal Article -
3
Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B
Published in Bioorganic & medicinal chemistry letters (15-07-2022)“…[Display omitted] The discovery of potent and selective inhibitors for understudied kinases can provide relevant pharmacological tools to illuminate their…”
Get full text
Journal Article -
4
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors
Published in Scientific reports (11-11-2019)“…Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via…”
Get full text
Journal Article -
5
A Target Engagement Assay to Assess Uptake, Potency, and Retention of Antibiotics in Living Bacteria
Published in ACS infectious diseases (12-08-2022)“…New antibiotics are urgently needed to counter the emergence of antimicrobial-resistant pathogenic bacteria. A major challenge in antibiotic drug discovery is…”
Get full text
Journal Article -
6
Satisfaction of Children with Auditory Neuropathy and Cochlear Implant
Published in The journal of international advanced otology (01-12-2015)“…In auditory neuropathy (AN) a dyssynchrony in the nerve conduction of the auditory nerve fibers is observed. Typically, patients with AN exhibit moderate to…”
Get full text
Journal Article -
7
Enterotoxigenic and nontoxigenic Bacteroides fragilis strains isolated in Brazil
Published in Memórias do Instituto Oswaldo Cruz (01-11-2008)“…The presence of enterotoxigenic Bacteroides fragilis and nontoxigenic B. fragilis (NTBF) among 109 strains isolated from 1980-2008 in Brazil were investigated…”
Get full text
Journal Article -
8
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε
Published in Journal of medicinal chemistry (13-06-2024)“…Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) are linked to various disease-relevant pathways. However, the lack of tool…”
Get full text
Journal Article -
9
Optimization of simultaneous screening of the main mutations involved in non-syndromic deafness using the TaqMan® OpenArray™ Genotyping platform
Published in BMC medical genetics (24-10-2013)“…Hearing loss is the most common sensory deficit in humans, affecting approximately 10% of the global population. In developed countries, one in every 500…”
Get full text
Journal Article -
10
Binding and structural analyses of potent inhibitors of the human Ca 2+ /calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors
Published in Scientific reports (11-11-2019)“…Calcium/Calmodulin-dependent Protein Kinase Kinase 2 (CAMKK2) acts as a signaling hub, receiving signals from various regulatory pathways and decoding them via…”
Get full text
Journal Article -
11
Enterotoxigenic and nontoxigenic Bacteroides fragilis strains isolated in Brazil
Published in Memórias do Instituto Oswaldo Cruz (21-01-2009)“…The presence of enterotoxigenic Bacteroides fragilis and nontoxigenic B. fragilis (NTBF) among 109 strains isolated from 1980-2008 in Brazil were investigated…”
Get full text
Journal Article