Search Results - "Ramos, Isbaal"
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Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models
Published in Scientific reports (28-01-2021)“…Neutrophil gelatinase-associated lipocalin (NGAL) is involved in cardiovascular and renal diseases. Gene inactivation of NGAL blunts the pathophysiological…”
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Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents
Published in Molecules (Basel, Switzerland) (01-01-2024)“…One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal…”
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3
Versatile fabrication method for multiscale hierarchical structured polymer masters using a combination of photo- and nanoimprint lithography
Published in Micro and Nano Engineering (01-04-2021)“…We present a versatile and scalable method for the preparation of microfluidic channels with incorporated nano patterns. Since our approach is highly…”
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4
Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity
Published in Biomedicines (06-03-2022)“…Neurotrophins are growth factors that exert important neuroprotective effects by preventing neuronal death and synaptic loss. Nerve Growth Factor (NGF) acts…”
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Consequences of Amyloid‐β Deficiency for the Liver
Published in Advanced science (01-05-2024)“…The hepatic content of amyloid beta (Aβ) decreases drastically in human and rodent cirrhosis highlighting the importance of understanding the consequences of…”
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Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease
Published in PLoS neglected tropical diseases (01-01-2018)“…Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic…”
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Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out
Published in Nanomaterials (Basel, Switzerland) (01-04-2021)“…The UV-nanoimprint lithography(UV-NIL) fabrication of a novel network of micron-sized channels, forming an open channel microfluidic system is described…”
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8
Phosphorylation of Both Nucleoplasmin Domains Is Required for Activation of Its Chromatin Decondensation Activity
Published in The Journal of biological chemistry (20-07-2007)“…Nucleoplasmin (NP) is a histone chaperone involved in nucleosome assembly, chromatin decondensation at fertilization, and apoptosis. To carry out these…”
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Myocardial fibrosis: biomedical research from bench to bedside
Published in European journal of heart failure (01-02-2017)“…Myocardial fibrosis refers to a variety of quantitative and qualitative changes in the interstitial myocardial collagen network that occur in response to…”
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10
Design, synthesis and biological characterization of novel activators of the TrkB neurotrophin receptor
Published in European journal of medicinal chemistry (15-02-2023)“…Numerous studies have been published about the implication of the neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the…”
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11
Development of Pleiotropic TrkB and 5-HT[sub.4] Receptor Ligands as Neuroprotective Agents
Published in Molecules (Basel, Switzerland) (01-01-2024)“…One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal…”
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12
Development of Pleiotropic TrkB and 5-HT 4 Receptor Ligands as Neuroprotective Agents
Published in Molecules (Basel, Switzerland) (19-01-2024)“…One common event that is the most detrimental in neurodegenerative disorders, even though they have a complex pathogenesis, is the increased rate of neuronal…”
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13
Activity of Bisnaphthalimidopropyl Derivatives against Trypanosoma brucei
Published in Antimicrobial agents and chemotherapy (01-04-2016)“…Current treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance. This study evaluated the…”
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14
The intrinsically disordered distal face of nucleoplasmin recognizes distinct oligomerization states of histones
Published in Nucleic acids research (01-01-2014)“…The role of Nucleoplasmin (NP) as a H2A-H2B histone chaperone has been extensively characterized. To understand its putative interaction with other histone…”
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15
Nucleoplasmin Binds Histone H2A-H2B Dimers through Its Distal Face
Published in The Journal of biological chemistry (29-10-2010)“…Nucleoplasmin (NP) is a pentameric chaperone that regulates the condensation state of chromatin extracting specific basic proteins from sperm chromatin and…”
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16
Nucleoplasmin: a nuclear chaperone
Published in Biochemistry and cell biology (01-08-2004)“…In this article, we briefly review the structural and functional information currently available on nucleoplasmin. Special emphasis is placed on the discussion…”
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Nucleoplasmin-Mediated Unfolding of Chromatin Involves the Displacement of Linker-Associated Chromatin Proteins
Published in Biochemistry (Easton) (14-06-2005)“…We have previously characterized the interaction of nucleoplasmin with core histones and studied the possible involvement of this chaperone molecule in…”
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