Search Results - "Ramos, Isalira P"
-
1
TGF-β inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease
Published in PLoS neglected tropical diseases (01-07-2019)“…TGF-β involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-β signaling pathway is activated in the cardiac tissue of chronic…”
Get full text
Journal Article -
2
Resveratrol Reverses Functional Chagas Heart Disease in Mice
Published in PLoS pathogens (01-10-2016)“…Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite…”
Get full text
Journal Article -
3
Role of SOCS2 in Modulating Heart Damage and Function in a Murine Model of Acute Chagas Disease
Published in The American journal of pathology (01-07-2012)“…Infection with Trypanosoma cruzi induces inflammation, which limits parasite proliferation but may result in chagasic heart disease. Suppressor of cytokine…”
Get full text
Journal Article -
4
Water-soluble lectin (WSMoL) from Moringa oleifera seeds treatment recovers glycemic levels and improves left ventricular ejection fraction on Type-2 Diabetes mice model
Published in Anais da Academia Brasileira de Ciências (2021)“…Moringa oleifera, a plant widely used in traditional medicine as well as for water purification, contains a lectin on its seeds named WSMoL which modulates…”
Get full text
Journal Article -
5
Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity
Published in PLoS neglected tropical diseases (01-08-2015)“…Chagas disease, caused by the protozoan Trypanosoma cruzi (T. cruzi), is a complex disease endemic in Central and South America. It has been gathering interest…”
Get full text
Journal Article -
6
Echocardiographic Measurements in a Preclinical Model of Chronic Chagasic Cardiomyopathy in Dogs: Validation and Reproducibility
Published in Frontiers in cellular and infection microbiology (24-09-2019)“…The failure to translate preclinical results to the clinical setting is the rule, not the exception. One reason that is frequently overlooked is whether the…”
Get full text
Journal Article -
7
Heart function enhancement with Nrf2-activating antioxidant in acute Y-strain Chagas disease, not in chronic Colombian or Y-strain
Published in PLoS neglected tropical diseases (07-11-2024)“…Oxidative stress promotes T . cruzi growth and development of chronic Chagas heart dysfunction. However, the literature contains gaps that must be fulfilled,…”
Get full text
Journal Article -
8
Progression of heart failure is attenuated by antioxidant therapy with N-acetylcysteine in myocardial infarcted female rats
Published in Molecular biology reports (01-11-2020)“…This study investigated the therapeutic potential of N-acetylcysteine (NAC) in the treatment of heart failure in female rats. Myocardial infarcted (MI) rats…”
Get full text
Journal Article -
9
A combination of stereological methods, biochemistry and electron microscopy for the investigation of drug treatment effects in experimental animals
Published in Journal of microscopy (Oxford) (01-03-2016)“…Summary Some chemotherapeutic agents used for breast cancer (BC) treatment can induce severe side effects in the ovarian tissue. The combination of…”
Get full text
Journal Article -
10
(99m)Tc-ixolaris targets glioblastoma-associated tissue factor: in vitro and pre-clinical applications
Published in Thrombosis research (01-08-2015)“…The clotting initiator protein tissue factor (TF) has recently been described as a potential target that can be exploited to image aggressive tumors. Ixolaris…”
Get full text
Journal Article -
11
Improvement of cardiac function by placenta-derived mesenchymal stem cells does not require permanent engraftment and is independent of the insulin signaling pathway
Published in Stem cell research & therapy (21-08-2014)“…The objective of this work was to evaluate the efficacy of placenta-derived mesenchymal stem cell (MSC) therapy in a mouse model of myocardial infarction (MI)…”
Get full text
Journal Article -
12
Comparison between Variable and Conventional Volume-Controlled Ventilation on Cardiorespiratory Parameters in Experimental Emphysema
Published in Frontiers in physiology (30-06-2016)“…Emphysema is characterized by loss of lung tissue elasticity and destruction of structures supporting alveoli and capillaries. The impact of mechanical…”
Get full text
Journal Article -
13
Comparison between effects of pressure support and pressure-controlled ventilation on lung and diaphragmatic damage in experimental emphysema
Published in Intensive care medicine experimental (01-12-2016)“…Background In patients with emphysema, invasive mechanical ventilation settings should be adjusted to minimize hyperinflation while reducing respiratory effort…”
Get full text
Journal Article -
14
TGF-[beta] inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas' heart disease
Published in PLoS neglected tropical diseases (31-07-2019)“…TGF-[beta] involvement in Chagas disease cardiomyopathy has been clearly demonstrated. The TGF-[beta] signaling pathway is activated in the cardiac tissue of…”
Get full text
Journal Article -
15
99mTc-ixolaris targets glioblastoma-associated tissue factor: In vitro and pre-clinical applications
Published in Thrombosis research (01-08-2015)“…The clotting initiator protein tissue factor (TF) has recently been described as a potential target that can be exploited to image aggressive tumors. Ixolaris…”
Get full text
Journal Article -
16
99m Tc-ixolaris targets glioblastoma-associated tissue factor: In vitro and pre-clinical applications
Published in Thrombosis research (2015)“…Abstract Background The clotting initiator protein tissue factor (TF) has recently been described as a potential target that can be exploited to image…”
Get full text
Journal Article -
17
Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity: e0003945
Published in PLoS neglected tropical diseases (01-08-2015)“…Background Chagas disease, caused by the protozoan Trypanosoma cruzi (T.cruzi), is a complex disease endemic in Central and South America. It has been…”
Get full text
Journal Article