Poly(N-isopropylacrylamide)/galactomannan from Delonix regia seed thermal responsive graft copolymer via Schiff base reaction

Poly(N-isopropylacrylamide)/galactomannan from Delonix regia seed thermal responsive graft copolymer via Schiff base reaction

Aminated poly(N-isopropylacrylamide) (PNIPAm-NH2) was grafted onto oxidized galactomannan polysaccharide extracted from Delonix regia (OXGM) via Schiff base reaction by a simple, rapid synthetic route, deprived of the use of organic solvents. Grafting was confirmed by FTIR and 1H NMR and the self-or...

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Bibliographic Details
Published in:International journal of biological macromolecules Vol. 166; pp. 144 - 154
Main Authors: Lima, Laís Ramos Monteiro, Ramos, Everton Lucas de Lima, Silva, Maria Francilene Souza, Ribeiro, Fábio de Oliveira Silva, Sousa, Jeanlex S., Pessoa, Claudia, Silva, Durcilene Alves, Feitosa, Judith P.A., Paula, Haroldo C.B., de Paula, Regina Célia Monteiro
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-01-2021
Subjects:
Acrylic Resins - chemistry
Biocompatible Materials - chemical synthesis
Copolymer
Fabaceae - chemistry
Galactomannan
Mannans - chemistry
Nanoparticle
Poly(N-isopropylacrylamide)
Polymerization
Schiff base
Schiff Bases - chemistry
Seeds - chemistry
Transition Temperature
Schiff base
Galactomannan
Copolymer
Poly(N-isopropylacrylamide)
Nanoparticle
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Summary:Aminated poly(N-isopropylacrylamide) (PNIPAm-NH2) was grafted onto oxidized galactomannan polysaccharide extracted from Delonix regia (OXGM) via Schiff base reaction by a simple, rapid synthetic route, deprived of the use of organic solvents. Grafting was confirmed by FTIR and 1H NMR and the self-organizing ability of the obtained nanoparticle copolymers was investigated by dynamic light scattering (DLS). The minimum concentration required for self-organization (CAC) at 25 °C was higher than at 50 °C. Lower critical solution temperature (LCST) was in the range 34–40 °C, depending on both inserted PNIPAm-NH2 molar mass and on the presence of reduced imine bond. Synthesized copolymers are promising candidates for drug delivery as they show good cell viability, particle size around 250 nm and transition temperature closer to that of human body. Reaction success points out to the possibility of use free aldehyde groups of oxidized polysaccharide, not used in the copolymerization, to form a pro-drug with substances that possess NH2 groups in their structure, such as doxorubicin. [Display omitted] •New synthesis of galactomannan/PNIPAm copolymers based on Schiff base reaction•Copolymers have non-cytotoxicity.•Transition temperature closer to human body temperature•Synthesized copolymers are promising candidates for drug delivery.
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ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2020.10.121