Search Results - "Ramonell, Richard P."
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Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID
Published in Nature communications (14-07-2023)“…While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to…”
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Effect of Anti-IL5, Anti-IL5R, Anti-IL13 Therapy on Asthma Exacerbations: A Network Meta-analysis
Published in Lung (01-02-2020)“…Background Several new treatments for severe asthma have become available in the last decade; yet, little data exist to guide their use in specific patient…”
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Diagnosis of Streptococcus pneumoniae infection using circulating antibody secreting cells
Published in PloS one (12-11-2021)“…Streptococcus pneumoniae infections cause morbidity and mortality worldwide. A rapid, simple diagnostic method could reduce the time needed to introduce…”
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Longitudinal trends using a point-of-care gelatin-based model for ultrasound-guided central venous catheter insertion
Published in Medical education online (01-01-2021)“…Ultrasound (US)-guided central venous catheter (CVC) insertion is a procedure that carries the risk of significant complications. Simulation provides a safe…”
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Checklists Improve Team Performance During Simulated Extracorporeal Membrane Oxygenation Emergencies: A Randomized Trial
Published in Critical care explorations (26-04-2021)“…Extracorporeal membrane oxygenation-related complications are potentially catastrophic if not addressed quickly. Because complications are rare, high-fidelity…”
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Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa
Published in Mucosal immunology (01-09-2021)Get full text
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Bridging the Gap between Innate and Adaptive Immunity in the Lung: Summary of the Aspen Lung Conference 2022
Published in American journal of respiratory cell and molecular biology (01-09-2023)“…Although significant strides have been made in the understanding of pulmonary immunology, much work remains to be done to comprehensively explain coordinated…”
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Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19
Published in Nature immunology (01-12-2020)“…A wide spectrum of clinical manifestations has become a hallmark of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic,…”
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Dysregulated naive B cells and de novo autoreactivity in severe COVID-19
Published in Nature (London) (03-11-2022)“…Severe SARS-CoV-2 infection 1 has been associated with highly inflammatory immune activation since the earliest days of the COVID-19 pandemic 2 – 5 . More…”
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Reduced COVID-19 Vaccine Response in Patients Treated with Biologic Therapies for Asthma
Published in American journal of respiratory and critical care medicine (15-05-2022)Get full text
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CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma
Published in Journal of allergy and clinical immunology (01-07-2023)“…Type 1 (T1) inflammation (marked by IFN-γ expression) is now consistently identified in subsets of asthma cohorts, but how it contributes to disease remains…”
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Wiping Out Wheezing: Novel Therapeutic Targets for Patients with Severe Asthma
Published in American journal of respiratory and critical care medicine (01-12-2020)“…Ramonell et al examine novel therapeutic targets for patients with severe asthma. In 2003, the first biologic therapy (omalizumab) for asthma was US Food and…”
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Detection of Newly Secreted Antibodies Predicts Nonrecurrence in Primary Clostridioides difficile Infection
Published in Journal of clinical microbiology (16-03-2022)“…Within 8 weeks of primary Clostridioides difficile infection (CDI), as many as 30% of patients develop recurrent disease with the associated risks of multiple…”
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Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity
Published in Journal of allergy and clinical immunology (01-08-2024)“…Biologic therapies inhibiting the IL-4 or IL-5 pathways are very effective in the treatment of asthma and other related conditions. However, the cytokines IL-4…”
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Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype
Published in Mucosal immunology (01-06-2023)“…Immunoglobulin (Ig) E is central to the pathogenesis of allergic conditions, including allergic fungal rhinosinusitis. However, little is known about IgE…”
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A peripheral cause of asthma: Peripheral T-cell lymphoma
Published in Annals of allergy, asthma, & immunology (01-04-2019)Get full text
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Recent Advances in Lung Immunobiology
Published in American journal of respiratory cell and molecular biology (01-12-2019)“…Ramonell argues on the study of Allie SR and colleague's The Establishment of Resident Memory B Cells in the Lung Requires Local Antigen Encounter. He said…”
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Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa
Published in Mucosal immunology (01-09-2021)“…Increased IgE is a typical feature of allergic rhinitis. Local class-switch recombination has been intimated but B cell precursors and mechanisms remain…”
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Transcriptional reprogramming of infiltrating neutrophils drives lung pathology in severe COVID-19 despite low viral load
Published in Blood advances (14-03-2023)“…•Blood neutrophils are transcriptionally reprogrammed within the airways of patients with severe COVID-19, exacerbating acute respiratory distress syndrome…”
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