Search Results - "Ramlaoui, Zainab"

IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status by Nandre, Rahul, Verma, Vivek, Gaur, Pankaj, Patil, Veerupaxagouda, Yang, Xingdong, Ramlaoui, Zainab, Shobaki, Nour, Andersen, Mads Hald, Pedersen, Ayako Wakatsuki, Zocca, Mai-Britt, Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N

“…The immunosuppressive tumor microenvironment (TME) does not allow generation and expansion of antitumor effector cells. One of the potent immunosuppressive…”
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The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment by Hardaker, Elizabeth L., Sanseviero, Emilio, Karmokar, Ankur, Taylor, Devon, Milo, Marta, Michaloglou, Chrysis, Hughes, Adina, Mai, Mimi, King, Matthew, Solanki, Anisha, Magiera, Lukasz, Miragaia, Ricardo, Kar, Gozde, Standifer, Nathan, Surace, Michael, Gill, Shaan, Peter, Alison, Talbot, Sara, Tohumeken, Sehmus, Fryer, Henderson, Mostafa, Ali, Mulgrew, Kathy, Lam, Carolyn, Hoffmann, Scott, Sutton, Daniel, Carnevalli, Larissa, Calero-Nieto, Fernando J., Jones, Gemma N., Pierce, Andrew J., Wilson, Zena, Campbell, David, Nyoni, Lynet, Martins, Carla P., Baker, Tamara, Serrano de Almeida, Gilberto, Ramlaoui, Zainab, Bidar, Abdel, Phillips, Benjamin, Boland, Joseph, Iyer, Sonia, Barrett, J. Carl, Loembé, Arsene-Bienvenu, Fuchs, Serge Y., Duvvuri, Umamaheswar, Lou, Pei-Jen, Nance, Melonie A., Gomez Roca, Carlos Alberto, Cadogan, Elaine, Critichlow, Susan E., Fawell, Steven, Cobbold, Mark, Dean, Emma, Valge-Archer, Viia, Lau, Alan, Gabrilovich, Dmitry I., Barry, Simon T.

“…The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical…”
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Abstract LB217: Ascorbic acid rescues antitumor immune response by reversing hypoxia-induced CD8+T cell dysfunction by Jafarzadeh, Nazli, Gaur, Pankaj, Sarhan, Dareen, Shobaki, Nour, Traboulsi, Wael, Ramlaoui, Zainab, Verma, Vivek, Gupta, Seema, Khleif, Samir N.

“…Abstract Growing evidence suggests that hypoxia is one of the most important phenomena of solid tumors that supports tumor progression as well as therapeutic…”
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Abstract 4217: MEKi in combination with anti-OX40 generates metabolically fit effector CD8+ T cells, enhances stem cell-like memory CD8+ T cells, and leads to strong anti-tumor activity by Gaur, Pankaj, Verma, Vivek, Elayyan, Mays Alreem, Ramlaoui, Zainab, Barry, Simon T., Valge-Archer, Viia E., Smith, Paul D., Gupta, Seema, Khleif, Samir N.

“…Abstract In the tumor microenvironment (TME), T cell exhaustion and short persistence of effector cells are crucial factors that limit the efficacy of…”
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Abstract LB339: PARP inhibition reprograms CD8 T cells, enhancing their function and generation of prolonged memory, leading to greater anti-tumor immune response by Traboulsi, Wael, Kundu, Subhadip, Gaur, Pankaj, Ramlaoui, Zainab, Sarhan, Dareen, Shobaki, Nour, Lee, Jacob, Jafarzadeh, Nazli, Barry, Simon T., Valge-Archer, Viia E., Verma, Vivek, Gupta, Seema, Khleif, Samir N.

“…Abstract Olaparib is the most widely studied third-generation PARP inhibitor (PARPi) in clinical practice with a significant clinical outcome in BRCA deficient…”
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