Search Results - "Ramirez Labrada, Ariel"

Inflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison by Miguel, Diego, Ramirez‐Labrada, Ariel, Uranga, Iratxe, Hidalgo, Sandra, Santiago, Llipsy, Galvez, Eva María, Arias, Maykel, Pardo, Julián

“…Cytotoxic lymphocytes (CLs), and more specifically Tc and NK cells, are the main executors of cell death in the immune system, playing a key role during both…”
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CAR Immunotherapy for the treatment of infectious diseases: a systematic review by Morte-Romea, Elena, Pesini, Cecilia, Pellejero-Sagastizábal, Galadriel, Letona-Giménez, Santiago, Martínez-Lostao, Luis, Aranda, Silvia Loscos, Toyas, Carla, Redrado, Sergio, Dolader-Ballesteros, Elena, Arias, Maykel, Galvez, Eva M, Sanz-Pamplona, Rebeca, Pardo, Julián, Paño-Pardo, Jose Ramón, Ramírez-Labrada, Ariel

“…Immunotherapy treatments aim to modulate the host's immune response to either mitigate it in inflammatory/autoimmune disease or enhance it against infection or…”
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PD-1 is expressed in cytotoxic granules of NK cells and rapidly mobilized to the cell membrane following recognition of tumor cells by Pesini, Cecilia, Hidalgo, Sandra, Arias, Maykel A., Santiago, Llipsy, Calvo, Carlota, Ocariz-Díez, Maitane, Isla, Dolores, Lanuza, Pilar M., Agustín, M José, Galvez, Eva M, Ramírez-Labrada, Ariel, Pardo, Julián

“…The contribution of the T cell-related inhibitory checkpoint PD-1 to the regulation of NK cell activity is still not clear with contradictory results…”
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Adoptive NK Cell Transfer as a Treatment in Colorectal Cancer Patients: Analyses of Tumour Cell Determinants Correlating With Efficacy In Vitro and In Vivo by Lanuza, Pilar M., Alonso, M. Henar, Hidalgo, Sandra, Uranga-Murillo, Iratxe, García-Mulero, Sandra, Arnau, Raquel, Santos, Cristina, Sanjuan, Xavier, Santiago, Llipsy, Comas, Laura, Redrado, Sergio, Pazo-Cid, Roberto, Agustin-Ferrández, M. Jose, Jaime-Sánchez, Paula, Pesini, Cecilia, Gálvez, Eva M., Ramírez-Labrada, Ariel, Arias, Maykel, Sanz-Pamplona, Rebeca, Pardo, Julián

“…Background Colorectal cancer (CRC) is a heterogeneous disease with variable mutational profile and tumour microenvironment composition that influence tumour…”
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Microbiota and Lung Cancer. Opportunities and Challenges for Improving Immunotherapy Efficacy by Ocáriz-Díez, Maitane, Cruellas, Mara, Gascón, Marta, Lastra, Rodrigo, Martínez-Lostao, Luis, Ramírez-Labrada, Ariel, Paño, José Ramón, Sesma, Andrea, Torres, Irene, Yubero, Alfonso, Pardo, Julián, Isla, Dolores, Gálvez, Eva M.

“…The advances in molecular biology and the emergence of Next Generation Sequencing (NGS) have revealed that microbiome composition is closely related with…”
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Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer? by Lanuza, Pilar M, Pesini, Cecilia, Arias, Maykel A, Calvo, Carlota, Ramirez-Labrada, Ariel, Pardo, Julian

“…Immune checkpoint receptors (IC) positively or negatively regulate the activation of the host immune response, preventing unwanted reactions against…”
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Multiparametric in vitro and in vivo analysis of the safety profile of self-assembling peptides by Ramirez-Labrada, Ariel, Santiago, Llipsy, Pesini, Cecilia, Arrieta, Marta, Arias, Maykel, Calvo Pérez, Adanays, Ciulla, Maria Gessica, Forouharshad, Mahdi, Pardo, Julian, Gálvez, Eva M., Gelain, Fabrizio

“…Self-assembling peptides (SAPs) have gained significant attention in biomedicine because of their unique properties and ability to undergo molecular…”
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In-depth analysis of the interplay between oncogenic mutations and NK cell-mediated cancer surveillance in solid tumors by Pesini, Cecilia, Artal, Laura, Paúl Bernal, Jorge, Sánchez Martinez, Diego, Pardo, Julián, Ramírez-Labrada, Ariel

“…Natural killer (NK) cells play a crucial role in antitumoral and antiviral responses. Yet, cancer cells can alter themselves or the microenvironment through…”
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The Multifaceted Function of Granzymes in Sepsis: Some Facts and a Lot to Discover by Garzón-Tituaña, Marcela, Arias, Maykel A, Sierra-Monzón, José L, Morte-Romea, Elena, Santiago, Llipsy, Ramirez-Labrada, Ariel, Martinez-Lostao, Luis, Paño-Pardo, José R, Galvez, Eva M, Pardo, Julián

“…Sepsis is a serious global health problem. In addition to a high incidence, this syndrome has a high mortality and is responsible for huge health expenditure…”
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Unravelling the cellular response to the SARS-COV-2 vaccine in inflammatory bowel disease patients on biologic drugs by Martínez-Domínguez, Samuel J., García-Mateo, Sandra, Sainz-Arnal, Pilar, Martínez-García, Javier, Gallego-Llera, Beatriz, Lozano-Limones, María Jesús, Hidalgo, Sandra, Gargallo-Puyuelo, Carla J., Latre-Santos, Marta, Nocito-Colon, Maria Mercedes Lourdes, Martínez-Lostao, Luis, Refaie, Engy, Arroyo-Villarino, Maria Teresa, del Rio-Nechaevsky, Marcela, Ramirez-Labrada, Ariel, Pardo, Julián, Gomollón, Fernando, Baptista, Pedro M.

“…Suboptimal vaccine response is a significant concern in patients with Inflammatory Bowel Disease (IBD) receiving biologic drugs. This single-center…”
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A Subset of PD-1-Expressing CD56bright NK Cells Identifies Patients with Good Response to Immune Checkpoint Inhibitors in Lung Cancer by Gascón-Ruiz, Marta, Ramírez-Labrada, Ariel, Lastra, Rodrigo, Martínez-Lostao, Luis, Paño-Pardo, J. Ramón, Sesma, Andrea, Zapata-García, María, Moratiel, Alba, Quílez, Elisa, Torres-Ramón, Irene, Yubero, Alfonso, Domingo, María Pilar, Esteban, Patricia, Gálvez, Eva M., Pardo, Julián, Isla, Dolores

“…(1) Despite the effectiveness of immune checkpoint inhibitors (ICIs) in lung cancer, there is a lack of knowledge about predictive biomarkers. The objective of…”
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Peripheral Blood TCRβ Repertoire, IL15, IL2 and Soluble Ligands for NKG2D Activating Receptor Predict Efficacy of Immune Checkpoint Inhibitors in Lung Cancer by Sesma, Andrea, Pardo, Julian, Isla, Dolores, M Gálvez, Eva, Gascón-Ruiz, Marta, Martínez-Lostao, Luis, Moratiel, Alba, Paño-Pardo, J Ramón, Quílez, Elisa, Torres-Ramón, Irene, Yubero, Alfonso, Zapata-García, María, Domingo, María Pilar, Esteban, Patricia, Sanz Pamplona, Rebeca, Lastra, Rodrigo, Ramírez-Labrada, Ariel

“…The development of immune checkpoint inhibitors (ICIs) has changed the therapeutic paradigm of lung cancer (LC), becoming the standard of treatment for…”
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All-trans retinoic acid (ATRA) induces miR-23a expression, decreases CTSC expression and granzyme B activity leading to impaired NK cell cytotoxicity by Sanchez-Martínez, Diego, Krzywinska, Ewelina, Rathore, Moeez G., Saumet, Anne, Cornillon, Amelie, Lopez-Royuela, Nuria, Martínez-Lostao, Luis, Ramirez-Labrada, Ariel, Lu, Zhao-Yang, Rossi, Jean-François, Fernández-Orth, Dietmar, Escorza, Sergio, Anel, Alberto, Lecellier, Charles-Henri, Pardo, Julian, Villalba, Martin

“…•NK cell stimulation is acutely well conserved between individuals.•Regulation of mRNA expression is tighter than that of miRNA expression.•Different target…”
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Determination of the Concentration of IgG against the Spike Receptor-Binding Domain That Predicts the Viral Neutralizing Activity of Convalescent Plasma and Serum against SARS-CoV-2 by Santiago, Llipsy, Uranga-Murillo, Iratxe, Arias, Maykel, González-Ramírez, Andrés Manuel, Macías-León, Javier, Moreo, Eduardo, Redrado, Sergio, García-García, Ana, Taleb, Víctor, Lira-Navarrete, Erandi, Hurtado-Guerrero, Ramón, Aguilo, Nacho, Del Mar Encabo-Berzosa, Maria, Hidalgo, Sandra, Galvez, Eva M, Ramirez-Labrada, Ariel, de Miguel, Diego, Benito, Rafael, Miranda, Patricia, Fernández, Antonio, Domingo, José María, Serrano, Laura, Yuste, Cristina, Villanueva-Saz, Sergio, Paño-Pardo, José Ramón, Pardo, Julián

“…Several hundred millions of people have been diagnosed of coronavirus disease 2019 (COVID-19), causing millions of deaths and a high socioeconomic burden…”
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Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases by Senan-Salinas, Ana, Comas, Laura, Esteban, Patricia, Garzón-Tituaña, Marcela, Cheng, Zhiming, Santiago, Llipsy, Domingo, Maria Pilar, Ramírez-Labrada, Ariel, Paño-Pardo, José Ramón, Vendrell, Marc, Pardo, Julián, Arias, Maykel A., Galvez, Eva M.

“…Granzymes (Gzms), a family of serine proteases, expressed by immune and nonimmune cells, present perforin-dependent and independent intracellular and…”
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Integration of In Silico and In Vitro Analysis of Gliotoxin Production Reveals a Narrow Range of Producing Fungal Species by Redrado, Sergio, Esteban, Patricia, Domingo, María Pilar, Lopez, Concepción, Rezusta, Antonio, Ramirez-Labrada, Ariel, Arias, Maykel, Pardo, Julián, Galvez, Eva M

“…Gliotoxin is a fungal secondary metabolite with impact on health and agriculture since it might act as virulence factor and contaminate human and animal food…”
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Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo by Jarauta, Vidal, Jaime, Paula, Gonzalo, Oscar, de Miguel, Diego, Ramírez-Labrada, Ariel, Martínez-Lostao, Luis, Anel, Alberto, Pardo, Julián, Marzo, Isabel, Naval, Javier

“…Highlights • Carfilzomib induces apoptosis through Puma and Noxa up-regulation and interaction with Bax. • Carfilzomib induces autophagy, which is disrupted as…”
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All About (NK Cell-Mediated) Death in Two Acts and an Unexpected Encore: Initiation, Execution and Activation of Adaptive Immunity by Ramírez-Labrada, Ariel, Pesini, Cecilia, Santiago, Llipsy, Hidalgo, Sandra, Calvo-Pérez, Adanays, Oñate, Carmen, Andrés-Tovar, Alejandro, Garzón-Tituaña, Marcela, Uranga-Murillo, Iratxe, Arias, Maykel A, Galvez, Eva M, Pardo, Julián

“…NK cells are key mediators of immune cell-mediated cytotoxicity toward infected and transformed cells, being one of the main executors of cell death in the…”
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Granulysin induces apoptotic cell death and cleavage of the autophagy regulator Atg5 in human hematological tumors by Aporta, Adriana, Catalán, Elena, Galán-Malo, Patricia, Ramírez-Labrada, Ariel, Pérez, Marta, Azaceta, Gemma, Palomera, Luis, Naval, Javier, Marzo, Isabel, Pardo, Julián, Anel, Alberto

“…Granulysin is a protein present in the granules of human CTL and NK cells, with cytolytic activity against microbes and tumors. Previous work demonstrated that…”
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LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL by Parvin, Salma, Ramirez-Labrada, Ariel, Aumann, Shlomzion, Lu, XiaoQing, Weich, Natalia, Santiago, Gabriel, Cortizas, Elena M., Sharabi, Eden, Zhang, Yu, Sanchez-Garcia, Isidro, Gentles, Andrew J., Roberts, Evan, Bilbao-Cortes, Daniel, Vega, Francisco, Chapman, Jennifer R., Verdun, Ramiro E., Lossos, Izidore S.

“…Deficiency in DNA double-strand break (DSB) repair mechanisms has been widely exploited for the treatment of different malignances, including homologous…”
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