Search Results - "Ramirez, Jacqueline"

A bioinformatic prediction of antigen presentation from SARS‐CoV‐2 spike protein revealed a theoretical correlation of HLA‐DRB101 with COVID‐19 fatality in Mexican population: An ecological approach by Romero‐López, José Pablo, Carnalla‐Cortés, Martha, Pacheco‐Olvera, Diana L., Ocampo‐Godínez, Juan Moisés, Oliva‐Ramírez, Jacqueline, Moreno‐Manjón, Julia, Bernal‐Alferes, Brian, López‐Olmedo, Nancy, García‐Latorre, Ethel, Domínguez‐López, María Lilia, Reyes‐Sandoval, Arturo, Jiménez‐Zamudio, Luis

“…SARS‐CoV‐2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)‐based…”
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Comprehensive Pharmacogenetic Analysis of Irinotecan Neutropenia and Pharmacokinetics by INNOCENTI, Federico, KROETZ, Deanna L, SCHUETZ, Erin, DOLAN, M. Eileen, RAMIREZ, Jacqueline, RELLING, Mary, PEIXIAN CHEN, DAS, Soma, ROSNER, Gary L, RATAIN, Mark J

“…We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and…”
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Comparison of the Drug-Drug Interactions Potential of Erlotinib and Gefitinib via Inhibition of UDP-Glucuronosyltransferases by YONG LIU, RAMIREZ, Jacqueline, HOUSE, Larry, RATAIN, Mark J

“…We aimed to investigate and compare the effects of erlotinib and gefitinib on UDP-glucuronosyltransferase (UGT) activities and to quantitatively evaluate their…”
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The use of arts‐based methodologies and methods with young people with complex psychosocial needs: A systematic narrative review by Nathan, Sally, Hodgins, Michael, Wirth, Jonathan, Ramirez, Jacqueline, Walker, Natasha, Cullen, Patricia

“…Background Arts‐based methodologies and methods (ABM) can elicit rich and meaningful data with seldom‐heard groups and empower participants in research. Young…”
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Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors by Liu, Yong, Ramírez, Jacqueline, Ratain, Mark J.

“…WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Clinical cases reported that fatal acute liver failure occurred when paracetamol (acetaminophen) was…”
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Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment by Purushothaman, Anurag, Oliva-Ramírez, Jacqueline, Treekitkarnmongkol, Warapen, Sankaran, Deivendran, Hurd, Mark W, Putluri, Nagireddy, Maitra, Anirban, Haymaker, Cara, Sen, Subrata

“…Pancreatic ductal adenocarcinoma (PDAC) cells display extensive crosstalk with their surrounding environment to regulate tumor growth, immune evasion, and…”
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Crosstalk between circadian rhythmicity, mitochondrial dynamics and macrophage bactericidal activity by Oliva‐Ramírez, Jacqueline, Moreno‐Altamirano, María Maximina B., Pineda‐Olvera, Benjamín, Cauich‐Sánchez, Patricia, Sánchez‐García, F. Javier

“…Summary Biological functions show rhythmic fluctuations with 24‐hr periodicity regulated by circadian proteins encoded by the so‐called ‘clock’ genes. The…”
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Genetic Variants in the UDP-glucuronosyltransferase 1A1 Gene Predict the Risk of Severe Neutropenia of Irinotecan by INNOCENTI, Federico, UNDEVIA, Samir D, VOKES, Everett E, RATAIN, Mark J, IYER, Lalitha, PEI XIAN CHEN, DAS, Soma, KOCHERGINSKY, Masha, KARRISON, Theodore, JANISCH, Linda, RAMIREZ, Jacqueline, RUDIN, Charles M

“…Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the…”
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Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver by Liu, Wanqing, Ramírez, Jacqueline, Gamazon, Eric R, Mirkov, Snezana, Chen, Peixian, Wu, Kehua, Sun, Chang, Cox, Nancy J, Cook, Jr, Edwin, Das, Soma, Ratain, Mark J

“…The aim of this study was to discover cis- and trans-acting factors significantly affecting mRNA expression and catalytic activity of human hepatic…”
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Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children by Neumann, Elizabeth, Mehboob, Huma, Ramírez, Jacqueline, Mirkov, Snezana, Zhang, Min, Liu, Wanqing

“…UDP-glucuronosyltransferases (UGTs) are important phase II drug metabolism enzymes. The aim of this study was to explore the relationship between age and…”
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LprG and PE_PGRS33 Mycobacterium tuberculosis virulence factors induce differential mitochondrial dynamics in macrophages by Aguilar‐López, Bruno A., Correa, Francisco, Moreno‐ Altamirano, María Maximina B., Espitia, Clara, Hernández‐Longoria, Rocío, Oliva‐Ramírez, Jacqueline, Padierna‐Olivos, Juan, Sánchez‐García, Francisco J.

“…The interaction of a pathogen with its host cell takes place at different levels, including the bioenergetics adaptation of both the pathogen and the host cell…”
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Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10 by Ramírez, Jacqueline, Mirkov, Snezana, House, Larry K, Ratain, Mark J

“…OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We aimed to identify the…”
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Latest Updates in Dengue Fever Therapeutics: Natural, Marine and Synthetic Drugs by Hosseini, Samira, Muñoz-Soto, Rodrigo B, Oliva-Ramírez, Jacqueline, Vázquez-Villegas, Patricia, Aghamohammadi, Nasrin, Rodriguez-Garcia, Aida, Martinez-Chapa, Sergio O

“…In this paper, we review the history of Dengue, the mechanism of infection, the molecular characteristics and components of Dengue, the mechanism of entry to…”
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Prolonged Pharmacokinetic Interaction Between Capecitabine and a CYP2C9 Substrate, Celecoxib by Ramírez, Jacqueline, House, Larry K., Karrison, Theodore G., Janisch, Linda A., Turcich, Michelle, Salgia, Ravi, Ratain, Mark J., Sharma, Manish R.

“…This study investigated the time course and magnitude of the pharmacokinetic interaction between capecitabine and the cytochrome P450 (CYP) 2C9 substrate…”
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Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene by O'Brien, Valerie P, Bokelmann, Kristin, Ramírez, Jacqueline, Jobst, Karoline, Ratain, Mark J, Brockmöller, Jürgen, Tzvetkov, Mladen V

“…The organic cation transporter 1 (OCT1), also known as solute carrier family 22 member 1, is strongly and specifically expressed in the human liver. Here we…”
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Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients by Karas, Spinel, Etheridge, Amy S., Tsakalozou, Eleftheria, Ramírez, Jacqueline, Cecchin, Erika, van Schaik, Ron H.N., Toffoli, Giuseppe, Ratain, Mark J., Mathijssen, Ron H.J., Forrest, Alan, Bies, Robert R., Innocenti, Federico

“…Irinotecan (CPT-11) is an anticancer agent widely used in the treatment of a variety of adult solid tumors. The objective of this study was to develop an…”
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Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue by Innocenti, Federico, Cooper, Gregory M, Stanaway, Ian B, Gamazon, Eric R, Smith, Joshua D, Mirkov, Snezana, Ramirez, Jacqueline, Liu, Wanqing, Lin, Yvonne S, Moloney, Cliona, Aldred, Shelly Force, Trinklein, Nathan D, Schuetz, Erin, Nickerson, Deborah A, Thummel, Ken E, Rieder, Mark J, Rettie, Allan E, Ratain, Mark J, Cox, Nancy J, Brown, Christopher D

“…The discovery of expression quantitative trait loci ("eQTLs") can help to unravel genetic contributions to complex traits. We identified genetic determinants…”
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SNPs affecting serum metabolomic traits may regulate gene transcription and lipid accumulation in the liver by Mirkov, Snezana, Myers, Jamie L, Ramírez, Jacqueline, Liu, Wanqing

“…Abstract Objective Circulatory metabolites are important biomarkers for many diseases, especially metabolic disorders. The biological mechanism regulating…”
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Pharmacogenomic and Pharmacokinetic Determinants of Erlotinib Toxicity by RUDIN, Charles M, WANQING LIU, FACKENTHAL, Donna Lee, PEIXIAN CHEN, ARMSTRONG, Deborah K, BRAHMER, Julie R, FLEMING, Gini F, VOKES, Everett E, CARDUCCI, Michael A, RATAIN, Mark J, DESAI, Apurva, KARRISON, Theodore, XUEMIN JIANG, JANISCH, Linda, DAS, Soma, RAMIREZ, Jacqueline, POONKUZHALI, Balasubramanian, SCHUETZ, Erin

“…To assess the pharmacogenomic and pharmacokinetic determinants of skin rash and diarrhea, the two primary dose-limiting toxicities of the epidermal growth…”
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Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene by Innocenti, Federico, Liu, Wanqing, Fackenthal, Donna, Ramírez, Jacqueline, Chen, PeiXian, Ye, Xin, Wu, Xiaolin, Zhang, Wei, Mirkov, Snezana, Das, Soma, Cook, Edwin, Ratain, Mark J

“…OBJECTIVEUDP-glucuronosyltransferase 2B7 (UGT2B7) plays a central role in the liver-mediated biotransformation of endogenous and exogenous compounds. The…”
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