The absorption of dietary phosphorus and calcium in hemodialysis patients

The absorption of dietary phosphorus and calcium in hemodialysis patients

The absorption of dietary phosphorus and calcium in hemodialysis patients. Absorption of dietary phosphorus plays a critical role in the development of metabolic bone diseases in patients with chronic renal failure. However, phosphorus absorption is difficult to quantitate in dialysis patients becau...

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Bibliographic Details
Published in:Kidney international Vol. 30; no. 5; pp. 753 - 759
Main Authors: Ramirez, J. Arnaldo, Emmett, Michael, White, Martin G., Fathi, Nastaran, Santa Ana, Carol A., Morawski, Stephen G., Fordtran, John S.
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-11-1986
Nature Publishing
Subjects:
Adult
Aged
Aluminum Hydroxide - pharmacology
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antacids - pharmacology
Biological and medical sciences
Calcitriol - pharmacology
Calcium Carbonate - pharmacology
Calcium, Dietary - metabolism
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
Intensive care medicine
Intestinal Absorption
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Male
Medical sciences
Middle Aged
Phosphorus - metabolism
Renal Dialysis
Human
Extrarenal dialysis
Urinary system disease
Calcium
Maintenance hemodialysis
Phosphorus
Metabolism
Inorganic element
Resuscitation
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Summary:The absorption of dietary phosphorus and calcium in hemodialysis patients. Absorption of dietary phosphorus plays a critical role in the development of metabolic bone diseases in patients with chronic renal failure. However, phosphorus absorption is difficult to quantitate in dialysis patients because the dialysis treatments complicate metabolic balance studies. Utilizing a recently developed technique which permits measurement of net absorption of dietary constituents after a single meal, we measured phosphorus absorption in dialysis patients. The following observations were made: A.) Following a meal containing approximately 300mg phosphorus, mean phosphorus absorption in five hemodialysis patients (with severe vitamin D deficiency) was only slightly less than in matched controls (186 ± 35 vs. 242 ± 30). B.) After dialysis patients were treated with 1,25(OH)2-D3, phosphorus absorption increased from 186 ± 35 to 272 ± 16mg (P < 0.025). C.) The effect of three aluminum containing antacids on phosphorus absorption was studied; each slightly reduced the absorption of phosphorus compared to placebo (P < 0.01), but there was no significant difference between them. D.) Aluminum hydroxide and calcium carbonate each reduced dietary phosphorus absorption to approximately the same extent. Calcium carbonate ingestion was associated with sharply increased calcium absorption. The absorption of dietary phosphorus is influenced only modestly by 1,25(OH)2-D3 and is inhibited to an equal but only modest degree by various aluminum antacids and by calcium carbonate.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.1986.252