Search Results - "Ramirez, Dominique A."

Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in Human and Canine Glioma Cells by Gross, Chase, Ramirez, Dominique A., McGrath, Stephanie, Gustafson, Daniel L.

“…Cannabidiol (CBD), the major non-psychoactive compound found in cannabis, is frequently used both as a nutraceutical and therapeutic. Despite anecdotal…”
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Programmable de novo designed coiled coil-mediated phase separation in mammalian cells by Ramšak, Maruša, Ramirez, Dominique A., Hough, Loren E., Shirts, Michael R., Vidmar, Sara, Eleršič Filipič, Kristina, Anderluh, Gregor, Jerala, Roman

“…Membraneless liquid compartments based on phase-separating biopolymers have been observed in diverse cell types and attributed to weak multivalent interactions…”
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Kinetics of Cyclophosphamide Metabolism in Humans, Dogs, Cats, and Mice and Relationship to Cytotoxic Activity and Pharmacokinetics by Ramirez, Dominique A, Collins, Keagan P, Aradi, Allister E, Conger, Katherine A, Gustafson, Daniel L

“…Cyclophosphamide (CP), a prodrug that is enzymatically converted to the cytotoxic 4-hydroxycyclophosphamide (4OHCP) by hepatic enzymes, is commonly used in…”
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Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism by Witta, Sandra, Collins, Keagan P., Ramirez, Dominique A., Mannheimer, Joshua D., Wittenburg, Luke A., Gustafson, Daniel L.

“…Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic…”
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Coiled-coil domains can drive liquid-liquid phase separation by Ramirez, Dominique A., Hough, Loren E., Shirts, Michael R.

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Identifying signatures of proteolytic stability and monomeric propensity in O-glycosylated insulin using molecular simulation by Hsu, Wei-Tse, Ramirez, Dominique A., Sammakia, Tarek, Tan, Zhongping, Shirts, Michael R.

“…Insulin has been commonly adopted as a peptide drug to treat diabetes as it facilitates the uptake of glucose from the blood. The development of oral insulin…”
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First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer by Abbott, Joshua M, Zhou, Qiong, Esquer, Hector, Pike, Laura, Broneske, Travis P, Rinaldetti, Sébastien, Abraham, Adedoyin D, Ramirez, Dominique A, Lunghofer, Paul J, Pitts, Todd M, Regan, Daniel P, Tan, Aik Choon, Gustafson, Daniel L, Messersmith, Wells A, LaBarbera, Daniel V

“…Since the discovery of CHD1L in 2008, it has emerged as an oncogene implicated in the pathology and poor prognosis of a variety of cancers, including…”
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Drug Design Targeting T‑Cell Factor-Driven Epithelial–Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer by Abraham, Adedoyin D, Esquer, Hector, Zhou, Qiong, Tomlinson, Nicholas, Hamill, Brayden D, Abbott, Joshua M, Li, Linfeng, Pike, Laura A, Rinaldetti, Sébastien, Ramirez, Dominique A, Lunghofer, Paul J, Gomez, Jose D, Schaack, Jerome, Nemkov, Travis, D’Alessandro, Angelo, Hansen, Kirk C, Gustafson, Daniel L, Messersmith, Wells A, LaBarbera, Daniel V

“…Metastasis is the cause of 90% of mortality in cancer patients. For metastatic colorectal cancer (mCRC), the standard-of-care drug therapies only palliate the…”
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