Search Results - "Ramesh, Radha"

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids by Ramesh, Radha, Kozhaya, Lina, McKevitt, Kelly, Djuretic, Ivana M, Carlson, Thaddeus J, Quintero, Maria A, McCauley, Jacob L, Abreu, Maria T, Unutmaz, Derya, Sundrud, Mark S

“…IL-17A-expressing CD4(+) T cells (Th17 cells) are generally regarded as key effectors of autoimmune inflammation. However, not all Th17 cells are…”
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Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo by Skepner, Jill, Ramesh, Radha, Trocha, Mark, Schmidt, Darby, Baloglu, Erkan, Lobera, Mercedes, Carlson, Thaddeus, Hill, Jonathan, Orband-Miller, Lisa A, Barnes, Ashley, Boudjelal, Mohamed, Sundrud, Mark, Ghosh, Shomir, Yang, Jianfei

“…IL-17-producing CD4(+)Th17 cells, CD8(+)Tc17 cells, and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the…”
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Small-Molecule RORγt Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S., Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B., Young, Richard A., Zhong, Zhong, Hafler, David A., Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K.

“…We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including…”
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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy by Bonazzi, Simone, d'Hennezel, Eva, Beckwith, Rohan E J, Xu, Lei, Fazal, Aleem, Magracheva, Anna, Ramesh, Radha, Cernijenko, Artiom, Antonakos, Brandon, Bhang, Hyo-Eun C, Caro, Roxana García, Cobb, Jennifer S, Ornelas, Elizabeth, Ma, Xiaolei, Wartchow, Charles A, Clifton, Matthew C, Forseth, Ry R, Fortnam, Bethany Hughes, Lu, Hongbo, Csibi, Alfredo, Tullai, Jennifer, Carbonneau, Seth, Thomsen, Noel M, Larrow, Jay, Chie-Leon, Barbara, Hainzl, Dominik, Gu, Yi, Lu, Darlene, Meyer, Matthew J, Alexander, Dylan, Kinyamu-Akunda, Jacqueline, Sabatos-Peyton, Catherine A, Dales, Natalie A, Zécri, Frédéric J, Jain, Rishi K, Shulok, Janine, Wang, Y Karen, Briner, Karin, Porter, Jeffery A, Tallarico, John A, Engelman, Jeffrey A, Dranoff, Glenn, Bradner, James E, Visser, Michael, Solomon, Jonathan M

“…Malignant tumors can evade destruction by the immune system by attracting immune-suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription…”
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An Unusual Case of Colonic Intussusception Masquerading as a Transverse Colon Mass by Ramesh, Radha, Juhn, Alexander, Babey, Muriel, Patel, Kirtan, Liu, Benny

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Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells by Wan, Qi, Kozhaya, Lina, ElHed, Aimee, Ramesh, Radha, Carlson, Thaddeus J, Djuretic, Ivana M, Sundrud, Mark S, Unutmaz, Derya

“…Human memory T cells (T(M) cells) that produce IL-17 or IL-22 are currently defined as Th17 or Th22 cells, respectively. These T cell lineages are almost…”
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Phase I/II study of the LAG-3 inhibitor ieramilimab (LAG525) ± anti-PD-1 spartalizumab (PDR001) in patients with advanced malignancies by Schöffski, Patrick, Tan, Daniel S W, Martín, Miguel, Ochoa-de-Olza, María, Sarantopoulos, John, Carvajal, Richard D, Kyi, Chrisann, Esaki, Taito, Prawira, Amy, Akerley, Wallace, De Braud, Filippo, Hui, Rina, Zhang, Tian, Soo, Ross A, Maur, Michela, Weickhardt, Andrew, Krauss, Jürgen, Deschler-Baier, Barbara, Lau, Allen, Samant, Tanay S, Longmire, Tyler, Chowdhury, Niladri Roy, Sabatos-Peyton, Catherine A, Patel, Nidhi, Ramesh, Radha, Hu, Tiancen, Carion, Ana, Gusenleitner, Daniel, Yerramilli-Rao, Padmaja, Askoxylakis, Vasileios, Kwak, Eunice L, Hong, David S

“…BackgroundLymphocyte-activation gene 3 (LAG-3) is an inhibitory immunoreceptor that negatively regulates T-cell activation. This paper presents preclinical…”
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Risk of stroke in hospitalized SARS-CoV-2 infected patients: A multinational study by Shahjouei, Shima, Naderi, Soheil, Li, Jiang, Khan, Ayesha, Chaudhary, Durgesh, Farahmand, Ghasem, Male, Shailesh, Griessenauer, Christoph, Sabra, Mirna, Mondello, Stefania, Cernigliaro, Achille, Khodadadi, Faezeh, Dev, Apoorva, Goyal, Nitin, Ranji-Burachaloo, Sakineh, Olulana, Oluwaseyi, Avula, Venkatesh, Ebrahimzadeh, Seyed Amir, Alizada, Orkhan, Hancı, Mehmet Murat, Ghorbani, Askar, Vaghefi far, Alaleh, Ranta, Annemarei, Punter, Martin, Ramezani, Mahtab, Ostadrahimi, Nima, Tsivgoulis, Georgios, Fragkou, Paraskevi C., Nowrouzi-Sohrabi, Peyman, Karofylakis, Emmanouil, Tsiodras, Sotirios, Neshin Aghayari Sheikh, Saeideh, Saberi, Alia, Niemelä, Mika, Rezai Jahromi, Behnam, Mowla, Ashkan, Mashayekhi, Mahsa, Bavarsad Shahripour, Reza, Sajedi, Seyed Aidin, Ghorbani, Mohammad, Kia, Arash, Rahimian, Nasrin, Abedi, Vida, Zand, Ramin

“…There is an increased attention to stroke following SARS-CoV-2. The goal of this study was to better depict the short-term risk of stroke and its associated…”
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Abstract 5184: Biomarker results from PEVENAZA, a randomized phase 2 study of venetoclax and azacitidine +/- pevonedistat in newly diagnosed AML patients unfit for intensive chemotherapy: Increased efficacy in a subset of patients with IDH1/2 mutations and other observations by Ramesh, Radha, Fang, Xiang, Li, Shuli, Friedlander, Sharon, Sedarati, Farhad, Adès, Lionel, Short, Nicholas, Papayannidis, Cristina, Yeh, Tammie

“…Abstract Background: Many newly diagnosed patients with AML are ineligible for intensive chemotherapy due to pre-existing comorbidities and older age. VIALE-A,…”
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Effect of first-line spartalizumab + dabrafenib + trametinib on immunosuppressive features detected in peripheral blood and clinical outcome in patients (pts) with advanced BRAF V600–mutant melanoma by Dummer, Reinhard, Biette, Kelly, Gusenleitner, Daniel, Ramesh, Radha, Lebbe, Celeste, Atkinson, Victoria, Mandalà, Mario, Nathan, Paul D., Arance, Ana, Richtig, Erika, Yamazaki, Naoya, Robert, Caroline, Schadendorf, Dirk, Tawbi, Hussein Abdul-Hassan, Ascierto, Paolo Antonio, Ribas, Antoni, Flaherty, Keith, Gasal, Eduard, Brase, Jan C., Long, Georgina V.

“…Abstract only 10034 Background: Spartalizumab + dabrafenib + trametinib has previously shown a high response rate of 78% (28 of 36 pts), with a complete…”
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Characterization of sabatolimab, a novel immunotherapy with immuno-myeloid activity directed against TIM-3 receptor by Schwartz, Stephanie, Patel, Nidhi, Longmire, Tyler, Jayaraman, Pushpa, Jiang, Xiaomo, Lu, Hongbo, Baker, Lisa, Velez, Janelle, Ramesh, Radha, Wavreille, Anne-Sophie, Verneret, Melanie, Fan, Hong, Hu, Tiancen, Xu, Fangmin, Taraszka, John, Pelletier, Marc, Miyashiro, Joy, Rinne, Mikael, Dranoff, Glenn, Sabatos-Peyton, Catherine, Cremasco, Viviana

“…Sabatolimab is a humanized monoclonal antibody (hIgG4, S228P) directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3). Herein, we…”
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Multi-drug resistant Th17 cells: new players in autoimmune and steroid-resistant inflammation (HUM8P.351) by Sundrud, Mark, Ramesh, Radha, Kozhaya, Lina, McKevitt, Kelly, Djuretic, Ivana, Carlson, Thaddeus, Quintero, Maria, McCauley, Jacob, Abreu, Maria

“…Abstract Th17 cells are generally regarded as key effectors of autoimmune disease. However, not all Th17 cells are pro-inflammatory. Furthermore, the defining…”
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In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists by Skepner, Jill, Trocha, Mark, Ramesh, Radha, Qu, Xiaoyan A., Schmidt, Darby, Baloglu, Erkan, Lobera, Mercedes, Davis, Scott, Nolan, Michael A., Carlson, Thaddeus J., Hill, Jonathan, Ghosh, Shomir, Sundrud, Mark S., Yang, Jianfei

“…Summary The orphan nuclear receptor, retinoic acid receptor‐related orphan nuclear receptor γt (RORγt), is required for the development and pathogenic function…”
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Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo (THER6P.855) by Yang, Jianfei, Skepner, Jill, Ramesh, Radha, Trocha, Mark, Schmidt, Darby, Baloglu, Erkan, Lobera, Mercedes, Carlson, Thaddeus, Hill, Jonathan, Miller, Lias, Barnes, Ashley, Boudjelal, Mohamed, Sundrud, Mark, Ghosh, Shomir

“…Abstract IL-17-producing Th17 cells, Tc17 cells and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the…”
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Consecutive low doses of cyclophosphamide preferentially target T regs and potentiate T cell responses induced by DNA PLG microparticle immunization by Barbon, Christine M., Yang, Min, Wands, Gregory D., Ramesh, Radha, Slusher, Barbara S., Hedley, Mary Lynne, Luby, Thomas M.

“…Cyclophosphamide in combination with immunotherapeutic approaches preferentially impinges on T reg activity and allows for robust generation of T cell…”
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In vivo regulation of gene expression and T helper type 17 differentiation by ROR[gamma]t inverse agonists by Skepner, Jill, Trocha, Mark, Ramesh, Radha, Qu, Xiaoyan A, Schmidt, Darby, Baloglu, Erkan, Lobera, Mercedes, Davis, Scott, Nolan, Michael A, Carlson, Thaddeus J, Hill, Jonathan, Ghosh, Shomir, Sundrud, Mark S, Yang, Jianfei

“…Summary The orphan nuclear receptor, retinoic acid receptor-related orphan nuclear receptor [gamma]t (ROR[gamma]t), is required for the development and…”
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Small-Molecule ROR[gamma]t Antagonists Inhibit T Helper 17 Cell Transcriptional Network by Divergent Mechanisms by Xiao, Sheng, Yosef, Nir, Yang, Jianfei, Wang, Yonghui, Zhou, Ling, Zhu, Chen, Wu, Chuan, Baloglu, Erkan, Schmidt, Darby, Ramesh, Radha, Lobera, Mercedes, Sundrud, Mark S, Tsai, Pei-Yun, Xiang, Zhijun, Wang, Jinsong, Xu, Yan, Lin, Xichen, Kretschmer, Karsten, Rahl, Peter B, Young, Richard A, Zhong, Zhong, Hafler, David A, Regev, Aviv, Ghosh, Shomir, Marson, Alexander, Kuchroo, Vijay K

“…We identified three retinoid-related orphan receptor gamma t (RORγt)-specific inhibitors that suppress T helper 17 (Th17) cell responses, including…”
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Consecutive low doses of cyclophosphamide preferentially target Tregs and potentiate T cell responses induced by DNA PLG microparticle immunization by Barbon, Christine M, Yang, Min, Wands, Gregory D, Ramesh, Radha, Slusher, Barbara S, Hedley, Mary Lynne, Luby, Thomas M

“…Cyclophosphamide in combination with immunotherapeutic approaches preferentially impinges on T(reg) activity and allows for robust generation of T cell…”
Get full text