Anti-Inflammatory Activity of Artemisia vulgaris Leaves, Originating from Three Different Altitudes of Nepal

This study aimed to evaluate and compare the in vivo chronic anti-inflammatory efficacy, from the ethyl acetate and ethanolic extracts of Artemisia vulgaris leaves, grown at three different altitudes in Nepal, by formalin-induced paw edema in Swiss albino mice. Edema was induced on the mice paw by a...

Full description

Saved in:

Bibliographic Details
Published in:	TheScientificWorld Vol. 2021; pp. 6678059 - 8
Main Authors:	Pandey, Jitendra, Bhusal, Sushma, Nepali, Laxman, Khatri, Maya, Ramdam, Rasmita, Barakoti, Himal, Giri, Paras Mani, Pant, Dhakaraj, Aryal, Pramod, Rokaya, Rabindra Kumar, Bhandari, Ravin
Format:	Journal Article
Language:	English
Published:	United States Hindawi 2021 John Wiley & Sons, Inc Hindawi Limited
Subjects:	Acetates Acetic acid Albinism Altitude Animals Anti-inflammatory agents Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Anti-inflammatory drugs Antidepressants Antimicrobial agents Artemisia - chemistry Artemisia vulgaris Body weight Edema Edema - drug therapy Esters Ethanol Ethyl acetate Female Formaldehyde In vivo methods and tests Indomethacin Inflammation Inflammation - drug therapy Injection Laboratories Leaves Male Medicinal plants Medicine, Botanic Medicine, Herbal Mice Nepal Plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves - chemistry Plants Sea level Thickness measurement Toxicity Nepal China
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	This study aimed to evaluate and compare the in vivo chronic anti-inflammatory efficacy, from the ethyl acetate and ethanolic extracts of Artemisia vulgaris leaves, grown at three different altitudes in Nepal, by formalin-induced paw edema in Swiss albino mice. Edema was induced on the mice paw by administering 0.2% of formalin injection. Indomethacin was used as a standard drug at the concentration of 5 mg/kg of body weight. Ethyl acetate and ethanolic leaves extract, at the concentration of 200 mg/kg and 400 mg/kg, were used as test drugs. Standard drug and all the extracts were administered 30 min before formalin injection. The paw thickness was measured at 0, 1, 2, 3, 24, 48, and 72 hours after formalin injection, using a Vernier caliper. It was observed that both ethyl acetate and ethanolic extract from all the altitudes exhibited significant inhibition of paw edema (p<0.05) induced by formalin. Maximum activity was shown by 400 mg/kg of the plant leaf extract taken from the temperate zone, with 54.05% of paw edema inhibition, and it is almost similar to the inhibition of standard drug (56.75%). Moreover, the ethanolic extract was found to be more effective than ethyl acetate extract in all the plant samples. The results suggested that the anti-inflammatory effect of A. vulgaris leaves increases with an increase in altitudes and this plant can be used as a useful source of medicine to treat chronic inflammation.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Academic Editor: Ahmad Mansour
ISSN:	2356-6140 1537-744X 1537-744X
DOI:	10.1155/2021/6678059