Search Results - "Ramanathan, M"

Piceatannol selectively inhibited the JNK3 enzyme and augmented apoptosis through inhibition of Bcl‐2/Cyt‐c/caspase‐dependent pathways in the oxygen–glucose deprived SHSY‐5Y cell lines: In silico and in vitro study by Rajan, Ravi Kumar, Ramanathan, M.

“…JNK3, a neuronal kinase activated by stress, plays a role in stress‐induced apoptosis, leading to neuronal cell death following cerebral ischemia. This study…”
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Identification and neuroprotective evaluation of a potential c-Jun N-terminal kinase 3 inhibitor through structure-based virtual screening and in-vitro assay by Rajan, Ravi Kumar, Ramanathan, M.

“…The c-Jun N-terminal kinase 3 (JNK3) signaling cascade is activated during cerebral ischemia leading to neuronal damage. The present study was carried out to…”
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Piceatannol improved cerebral blood flow and attenuated JNK3 and mitochondrial apoptotic pathway in a global ischemic model to produce neuroprotection by Rajan, Ravi Kumar, Kumar, Ram Pravin, Ramanathan, M.

“…Cerebral ischemia is one of the leading causes of death and disability worldwide. The only FDA-approved treatment is recanalization with systemic tissue…”
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Activation of AKT1/GSK-3β/β-Catenin–TRIM11/Survivin Pathway by Novel GSK-3β Inhibitor Promotes Neuron Cell Survival: Study in Differentiated SH-SY5Y Cells in OGD Model by Darshit, B. S., Ramanathan, M.

“…The objective of this study is to elucidate the effect of a new glycogen synthase kinase-3 β (GSK-3 β ) inhibitor in RA differentiated SH-SY5Y cells in oxygen…”
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Comparison of pterygomaxillary dysjunction with tuberosity separation in isolated Le Fort I osteotomies: a prospective, multi-centre, triple-blind, randomized controlled trial by Christabel, A, Anantanarayanan, P, Subash, P, Soh, C.L, Ramanathan, M, Muthusekhar, M.R, Narayanan, V

“…Abstract The aim of this trial was to compare two techniques of maxillary dysjunction, with 10 mg/kg tranexamic acid as an adjuvant, in isolated non-segmented…”
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Network-Based Approaches in Drug Discovery and Early Development by Harrold, J M, Ramanathan, M, Mager, D E

“…Identification of novel targets is a critical first step in the drug discovery and development process. Most diseases such as cancer, metabolic disorders, and…”
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Hiding in Plain Sight: A Case of Ornithine Transcarbamylase Deficiency Unmasked Post–Liver Transplantation by Ramanathan, M., Uppalapu, S., Patel, N. M.

“…Ornithine transcarbamylase deficiency represents the most common inherited defect of the urea cycle. This enzyme, predominantly found in the liver, plays a…”
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COVID-19 Pandemic is an Eye-Opener for Academicians to Use the Technology in the Teaching–Learning Process by Senthil Kumaran, Velayutham, Periakaruppan, Ramanathan M.

“…Few things exist in life from the beginning but you don't realize until they become a habit. Education is also one of those things which cannot be exempted…”
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Design, synthesis and biological evaluation of 2-(phenoxymethyl)-5-phenyl-1,3,4-oxadiazole derivatives as anti-breast cancer agents by Lakshmithendral, K., Saravanan, K., Elancheran, R., Archana, K., Manikandan, N., Arjun, H.A., Ramanathan, M., Lokanath, N.K., Kabilan, S.

“…Structural based molecular docking approach revealed the findings of 2-(phenoxymethyl) -5-phenyl-1,3,4-oxadiazole derivatives. The compounds (7a-o) were…”
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Electrochemical and thermal characterization of lithium titanate spinel anode in C–LiFePO4//C–Li4Ti5O12 cells at sub-zero temperatures by Zaghib, K., Dontigny, M., Perret, P., Guerfi, A., Ramanathan, M., Prakash, J., Mauger, A., Julien, C.M.

“…C-LiFePO4 and C-Li4Ti5O12 electrodes were studied for their electrochemical performance at sub-zero temperatures with two different electrolytes, conventional…”
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Epidemiological shifts in elderly traumatic brain injury: 18-year trends in Pennsylvania by Ramanathan, Deepa M, McWilliams, Nathan, Schatz, Philip, Hillary, Frank G

“…Older adults tend to have poorer outcomes compared to younger adults following moderate-to-severe traumatic brain injury (TBI). Currently, there is a need for…”
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Cholesterol and neurodegeneration: longitudinal changes in serum cholesterol biomarkers are associated with new lesions and gray matter atrophy in multiple sclerosis over 5 years of follow‐up by Murali, N., Browne, R. W., Fellows Maxwell, K., Bodziak, M. L., Jakimovski, D., Hagemeier, J., Bergsland, N., Weinstock‐Guttman, B., Zivadinov, R., Ramanathan, M.

“…Background and purpose Cholesterol is an important structural component of myelin and essential for brain homeostasis. Our objective was to investigate whether…”
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Cerebral ischemia induced inflammatory response and altered glutaminergic function mediated through brain AT1 and not AT2 receptor by Justin, A., Divakar, S., Ramanathan, M.

“…In the present study, we investigated the effects of angiotensin (Ang II) receptor blockers in cerebral ischemia by administration of telmisartan (AT1 blocker)…”
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Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS by ZIVADINOV, R, MARR, K, HUNT, K, ANDREWS, M, CARL, E, DWYER, M. G, HOJNACKI, D, WEINSTOCK-GUTTMAN, B, CUTTER, G, RAMANATHAN, M, BENEDICT, R. H. B, KENNEDY, C, ELFADIL, M, YEH, A. E, REUTHER, J, BROOKS, C

“…Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). A subject is considered CCSVI positive if ≥…”
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Evidence for a role of metformin in preventing olfactory dysfunction among older adults by Assi, S, Vohra, V, Zhang, W, Reed, N S, Lane, A P, Ramanathan, Jr, M, Rowan, N R

“…Olfactory dysfunction (OD) is increasingly recognized as a hallmark of unhealthy aging and is intimately associated with mortality, but therapies remain…”
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Identification of Information Flow-Modulating Drug Targets: A Novel Bridging Paradigm for Drug Discovery by Hwang, W‐C, Zhang, A, Ramanathan, M

“…Our objective in this study was to identify novel metrics for efficient identification of drug targets using biological network topology data. We developed a…”
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Enhanced thermal safety and high power performance of carbon-coated LiFePO4 olivine cathode for Li-ion batteries by Zaghib, K., Dubé, J., Dallaire, A., Galoustov, K., Guerfi, A., Ramanathan, M., Benmayza, A., Prakash, J., Mauger, A., Julien, C.M.

“…The carbon-coated LiFePO4 Li-ion oxide cathode was studied for its electrochemical, thermal, and safety performance. This electrode exhibited a reversible…”
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Evaluation of airflow characteristics before and after septoplasty in unilateral cleft patients with a deviated nasal septum: a computational fluid dynamics study by Ramanathan, M., Ramesh, P., Aggarwal, N., Parameswaran, A., Sailer, H.F., George, A.E.

“…The aim of this study was to evaluate changes in airflow characteristics before and after septoplasty in unilateral cleft lip and palate (UCLP) patients using…”
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Non-hypotensive dose of telmisartan and nimodipine produced synergistic neuroprotective effect in cerebral ischemic model by attenuating brain cytokine levels by Justin, A., Sathishkumar, M., Sudheer, A., Shanthakumari, S., Ramanathan, M.

“…The hypothesis of the present study is that the anti-inflammatory property of telmisartan (TM), an AT1 blocker that may exert neuroprotection through…”
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Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis by ZIVADINOV, R, WEINSTOCK-GUTTMAN, B, HASHMI, K, ABDELRAHMAN, N, STOSIC, M, DWYER, M, HUSSEIN, S, DURFEE, J, RAMANATHAN, M

“…Cigarette smoking has been linked to higher susceptibility and increased risk of progressive multiple sclerosis (MS). The effects of smoking on MRI…”
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