Search Results - "Ramamurthy, Nungavaram"

Experimental Arthritis in Rats Induces Biomarkers of Periodontitis Which Are Ameliorated by Gene Therapy With Tissue Inhibitor of Matrix Metalloproteinases by Ramamurthy, Nungavaram S., Greenwald, Robert A., Celiker, Mohamed Y., Shi, Eric Y.

“…Background: Periodontal disease (PD) and rheumatoid arthritis (RA) share many common pathophysiologic features, but a clinical relationship between the two…”
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Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease by RAMAMURTHY, Nungavaram S, XU, Jing-Wen, BIRD, John, BAXTER, Andrew, BHOGAL, Ranjev, WILLS, Ruth, WATSON, Bob, OWEN, David, WOLFF, Mark, GREENWALD, Robert A

“…Periodontal disease is characterized by excessive host collagenase resulting in loss of gingival and periodontal ligament collagen and adjacent alveolar bone…”
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A Combination of a Chemically Modified Doxycycline and a Bisphosphonate Synergistically Inhibits Endotoxin‐Induced Periodontal Breakdown in Rats by Llavaneras, Analeyda, Ramamurthy, Nungavaram S., Heikkilä, Pia, Teronen, Olli, Salo, Tuula, Rifkin, Barry R., Ryan, Maria E., Golub, Lorne M., Sorsa, Timo

“…Background: Chemically modified non‐antimicrobial tetracyclines (CMTs) have been shown to inhibit pathologically elevated collagenase (and other matrix…”
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Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva by Golub, L M, Sorsa, T, Lee, H M, Ciancio, S, Sorbi, D, Ramamurthy, N S, Gruber, B, Salo, T, Konttinen, Y T

“…We previously reported that low-dose doxycycline (DOXY) therapy reduces host-derived collagenase activity in gingival tissue of adult periodontitis (AP)…”
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Identification and characterization of gelatinases/type IV collagenases in jaw cysts by Teronen, O, Salo, T, Konttinen, Y T, Rifkin, B, Vernillo, A, Ramamurthy, N S, Kjeldsen, L, Borregaard, N, Hietanen, J, Sorsa, T

“…The molecular mechanisms of jaw cyst expansion probably involve interactions of matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs). In…”
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Enrichment of collagen and gelatin degrading activities in the plasma membranes of human cancer cells by ZUCKER, S, WIEMAN, J. M, LYSIK, R. M, WILKIE, D, RAMAMURTHY, N. S, GOLUB, L. M, LANE, B

“…Interactions between connective tissue substrates and proteinases localized to the surface of cancer cells are implicated in cancer invasion. In this report we…”
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Inhibition of adjuvant‐induced arthritis by systemic tissue inhibitor of metalloproteinases 4 gene delivery by Çeliker, Mahmut Y., Ramamurthy, Nungavaram, Xu, Jin‐Wen, Wang, Mingsheng, Jiang, Yangfu, Greenwald, Robert, Shi, Y. Eric

“…Objective An imbalance in the matrix metalloproteinase:tissue inhibitor of metalloproteinases (MMP:TIMP) ratio in favor of MMP appears to be an important…”
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Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine : A novel mechanism of anti-inflammatory activity by PRUZANSKI, W, STEFANSKI, E, VADAS, P, RAMAMURTHY, N. S

“…Sulfasalazine is widely used in rheumatoid arthritis and inflammatory bowel diseases. The mechanisms of its activity have not been elucidated. In leukocytes,…”
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In Vivo Crevicular Leukocyte Response to a Chemotactic Challenge: Inhibition by Experimental Diabetes by Golub, L M, Nicoll, G A, Iacono, V J, Ramamurthy, N S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Functional sites of chemically modified tetracyclines: inhibition of the oxidative activation of human neutrophil and chicken osteoclast pro-matrix metalloproteinases by Sorsa, T, Ramamurthy, N S, Vernillo, A T, Zhang, X, Konttinen, Y T, Rifkin, B R, Golub, L M

“…We studied the relative ability of 6 different chemically modified non-antimicrobial analogs of tetracycline (CMT) to inhibit human and chicken matrix…”
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Inhibition of extracellular release of proinflammatory secretory phospholipase A2 (sPLA2) by sulfasalazine by Pruzanski, Waldemar, Stefanski, Eva, Vadas, Peter, Ramamurthy, Nungavaram S.

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Inhibition of extracellular release of proinflammatory secretory phospholipase A 2 (sPLA 2) by sulfasalazine : A novel mechanism of anti-inflammatory activity by Pruzanski, Waldemar, Stefanski, Eva, Vadas, Peter, Ramamurthy, Nungavaram S.

“…Sulfasalazine is widely used in rheumatoid arthritis and inflammatory bowel diseases. The mechanisms of its activity have not been elucidated. In leukocytes,…”
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Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase by Ramamurthy, Nungavaram S., Vernillo, Anthony T., Greenwald, Robert A., Lee, H.‐M., Sorsa, Timo, Golub, Lorne M., Rifkin, Barry R.

“…Recent studies have demonstrated that tetracyclines (TCs) scavenge reactive oxygen species (ROS). Hypochlorous acid (HOCI), an ROS produced by neutrophils, has…”
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Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential by Suomalainen, K, Sorsa, T, Golub, L M, Ramamurthy, N, Lee, H M, Uitto, V J, Saari, H, Konttinen, Y T

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in exjreimental jreiodontal disease by Ramamurthy, Nungavaram S., Xu, Jing-wen, Bird, John, Baxter, Andrew, Bhogal, Ranjev, Wills, Ruth, Watson, Bob, Owen, David, Wolff, Mark, Greenwald, Robert A.

“…Jreiodontal disease is characterized by excessive host collagenase resulting in loss of gingival and jreiodontal ligament collagen and adjacent alveolar bone…”
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Tetracycline administration normalizes the structure and acid phosphatase activity of osteoclasts in streptozotocin-induced diabetic rats by Kaneko, H, Sasaki, T, Ramamurthy, N S, Golub, L M

“…Diabetes induces osteopenia, which is characterized by a deficiency of osteoid and decreased activity of osteoblasts. We recently found that tetracyclines…”
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Tetracycline administration increases collagen synthesis in osteoblasts of streptozotocin-induced diabetic rats : a quantitative autoradiographic study by SASAKI, T, RAMAMURTHY, N. S, GOLUB, L. M

“…Streptozotocin-induced, insulin-deficient diabetic rats were administrated either minocycline (MC) or a chemically modified non-antimicrobial tetracycline…”
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Diversity of melanoma plasma membrane proteinases: inhibition of collagenolytic and cytolytic activities by minocycline by Zucker, S, Lysik, R M, Ramamurthy, N S, Golub, L M, Wieman, J M, Wilkie, D P

“…The tissue-destructive proteinases of B16-BL6 melanoma cells from C57BL/6 mice and subcellular fractions were examined. Cancer cell organelles were isolated…”
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Tetracycline administration restores osteoblast structure and function during experimental diabetes by Sasaki, T, Kaneko, H, Ramamurthy, N S, Golub, L M

“…Osteopenia is a recognized complication of diabetes mellitus in humans and experimental animals. We recently found that tetracyclines prevent osteopenia in the…”
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Effects of ovariectomy on bone morphology in maxillae of mature rats by Ishihara, Akira, Sasaki, Takahisa, Debari, Kazuhiro, Furuya, Ryoichi, Kawawa, Tadaharu, Ramamurthy, Nungavaram S., Golub, Lome M.

“…Postmenopausal oestrogen deficiency results in bone loss (osteoporosis) in humans and experimental animals. The loss of trabecular bone in the ovariectomized…”
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