Search Results - "Ramamoorthy, Ayyalusamy"

Beyond NMR spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights by Ramamoorthy, Ayyalusamy

“…There is a considerable current interest in understanding the function of antimicrobial peptides for the development of potent novel antibiotic compounds with…”
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Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy: Advances in Methodology and Applications by Nishiyama, Yusuke, Hou, Guangjin, Agarwal, Vipin, Su, Yongchao, Ramamoorthy, Ayyalusamy

“…Solid-state NMR spectroscopy is one of the most commonly used techniques to study the atomic-resolution structure and dynamics of various chemical, biological,…”
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Studies on anticancer activities of antimicrobial peptides by Hoskin, David W., Ramamoorthy, Ayyalusamy

“…In spite of great advances in cancer therapy, there is considerable current interest in developing anticancer agents with a new mode of action because of the…”
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Proton-Based Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy by Zhang, Rongchun, Mroue, Kamal H, Ramamoorthy, Ayyalusamy

“…Protons are vastly abundant in a wide range of exciting macromolecules and thus can be a powerful probe to investigate the structure and dynamics at atomic…”
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Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective by Brender, Jeffrey R, Salamekh, Samer, Ramamoorthy, Ayyalusamy

“…The aggregation of proteins is tightly controlled in living systems, and misfolded proteins are normally removed before aggregation of the misfolded protein…”
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Detergent-free extraction, reconstitution and characterization of membrane-anchored cytochrome-b5 in native lipids by Krishnarjuna, Bankala, Ravula, Thirupathi, Ramamoorthy, Ayyalusamy

“…Despite their denaturing properties, detergents are used to purify and study membrane proteins. Herein, we demonstrated a polymer-based detergent-free…”
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Bioinspired, Size‐Tunable Self‐Assembly of Polymer–Lipid Bilayer Nanodiscs by Ravula, Thirupathi, Ramadugu, Sudheer Kumar, Di Mauro, Giacomo, Ramamoorthy, Ayyalusamy

“…Polymer‐based nanodiscs are valuable tools in biomedical research that can offer a detergent‐free solubilization of membrane proteins maintaining their native…”
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Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes by Milardi, Danilo, Gazit, Ehud, Radford, Sheena E, Xu, Yong, Gallardo, Rodrigo U, Caflisch, Amedeo, Westermark, Gunilla T, Westermark, Per, Rosa, Carmelo La, Ramamoorthy, Ayyalusamy

“…The possible link between hIAPP accumulation and β-cell death in diabetic patients has inspired numerous studies focusing on amyloid structures and aggregation…”
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Biophysical processes underlying cross-seeding in amyloid aggregation and implications in amyloid pathology by Ivanova, Magdalena I., Lin, Yuxi, Lee, Young-Ho, Zheng, Jie, Ramamoorthy, Ayyalusamy

“…Abnormal aggregation of proteins into filamentous aggregates commonly associates with many diseases, such as Alzheimer’s disease, Parkinson’s disease and…”
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Structure, membrane orientation, mechanism, and function of pexiganan — A highly potent antimicrobial peptide designed from magainin by Gottler, Lindsey M., Ramamoorthy, Ayyalusamy

“…The growing problem of bacterial resistance to conventional antibiotic compounds and the need for new antibiotics have stimulated interest in the development…”
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Detergent-Free Isolation of Membrane Proteins and Strategies to Study Them in a Near-Native Membrane Environment by Krishnarjuna, Bankala, Ramamoorthy, Ayyalusamy

“…Atomic-resolution structural studies of membrane-associated proteins and peptides in a membrane environment are important to fully understand their biological…”
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A partially folded structure of amyloid-beta(1–40) in an aqueous environment by Vivekanandan, Subramanian, Brender, Jeffrey R., Lee, Shirley Y., Ramamoorthy, Ayyalusamy

“…[Display omitted] ► Amyloid-beta (1–40) is partially folded at 15°C, pH 7.3 in 50mM NaCl. ► Amyloid-beta (1–40) forms a 310 helix from H13 to D23. ► N- and…”
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Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis by Nguyen, Phuong H, Ramamoorthy, Ayyalusamy, Sahoo, Bikash R, Zheng, Jie, Faller, Peter, Straub, John E, Dominguez, Laura, Shea, Joan-Emma, Dokholyan, Nikolay V, De Simone, Alfonso, Ma, Buyong, Nussinov, Ruth, Najafi, Saeed, Ngo, Son Tung, Loquet, Antoine, Chiricotto, Mara, Ganguly, Pritam, McCarty, James, Li, Mai Suan, Hall, Carol, Wang, Yiming, Miller, Yifat, Melchionna, Simone, Habenstein, Birgit, Timr, Stepan, Chen, Jiaxing, Hnath, Brianna, Strodel, Birgit, Kayed, Rakez, Lesné, Sylvain, Wei, Guanghong, Sterpone, Fabio, Doig, Andrew J, Derreumaux, Philippe

“…Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues…”
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Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy by Naito, Akira, Matsumori, Nobuaki, Ramamoorthy, Ayyalusamy

“…A variety of biomolecules acting on the cell membrane folds into a biologically active structure in the membrane environment. It is, therefore, important to…”
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Formation of pH‐Resistant Monodispersed Polymer–Lipid Nanodiscs by Ravula, Thirupathi, Hardin, Nathaniel Z., Ramadugu, Sudheer Kumar, Cox, Sarah J., Ramamoorthy, Ayyalusamy

“…Polymer lipid nanodiscs are an invaluable system for structural and functional studies of membrane proteins in their near‐native environment. Despite the…”
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Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival by Kamarajan, Pachiyappan, Hayami, Takayuki, Matte, Bibiana, Liu, Yang, Danciu, Theodora, Ramamoorthy, Ayyalusamy, Worden, Francis, Kapila, Sunil, Kapila, Yvonne

“…The use of small antimicrobial peptides or bacteriocins, like nisin, to treat cancer is a new approach that holds great promise. Nisin exemplifies this new…”
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The Magic of Bicelles Lights Up Membrane Protein Structure by Dürr, Ulrich H. N, Gildenberg, Melissa, Ramamoorthy, Ayyalusamy

“…Durr et al examine lipid bicelles with regard to membrane protein structure…”
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Spontaneous Lipid Nanodisc Fomation by Amphiphilic Polymethacrylate Copolymers by Yasuhara, Kazuma, Arakida, Jin, Ravula, Thirupathi, Ramadugu, Sudheer Kumar, Sahoo, Bikash, Kikuchi, Jun-ichi, Ramamoorthy, Ayyalusamy

“…There is a growing interest in the use of lipid bilayer nanodiscs for various biochemical and biomedical applications. Among the different types of nanodiscs,…”
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Structure and membrane orientation of IAPP in its natively amidated form at physiological pH in a membrane environment by Nanga, Ravi Prakash Reddy, Brender, Jeffrey R., Vivekanandan, Subramanian, Ramamoorthy, Ayyalusamy

“…Human islet amyloid polypeptide is a hormone coexpressed with insulin by pancreatic beta-cells. For reasons not clearly understood, hIAPP aggregates in type II…”
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Saponins Form Nonionic Lipid Nanodiscs for Protein Structural Studies by Nuclear Magnetic Resonance Spectroscopy by McCalpin, Samuel D, Ravula, Thirupathi, Ramamoorthy, Ayyalusamy

“…Structural studies of membrane proteins in native-like environments require the development of diverse membrane mimetics. Currently there is a need for…”
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