Lead and trace element levels in placenta, maternal and cord blood: A cross-sectional pilot study

Aim To determine lead (Pb) and trace element (Fe, Zn, Cu, Mg) levels in placenta, maternal and cord blood; further, to assess the interactions between Pb and trace elements, if any. Methods A cluster of ‘at term pregnant women’ from rural and urban areas (n = 30 each, total n = 60) as well as their...

Full description

Saved in:

Bibliographic Details
Published in:	The journal of obstetrics and gynaecology research Vol. 40; no. 12; pp. 2184 - 2190
Main Authors:	Reddy, Yathapu Srinivasa, Y, Aparna, Ramalaksmi, B. A., Kumar, B. Dinesh
Format:	Journal Article
Language:	English
Published:	Australia Blackwell Publishing Ltd 01-12-2014
Subjects:	Adolescent Adult Copper - analysis Copper - blood Copper - deficiency Cross-Sectional Studies Deficiency Diseases - blood Deficiency Diseases - epidemiology Deficiency Diseases - metabolism Female Fetal Blood - chemistry Humans India - epidemiology Iron - analysis Iron - blood Iron - deficiency Lead - analysis Lead - blood Lead - toxicity lead levels Lead Poisoning - blood Lead Poisoning - epidemiology Lead Poisoning - metabolism Magnesium - analysis Magnesium - blood Magnesium Deficiency - blood Magnesium Deficiency - epidemiology Magnesium Deficiency - metabolism Maternal Nutritional Physiological Phenomena neonate Pilot Projects Placenta - chemistry placental Pb levels post-partum women Pregnancy Pregnancy Complications - blood Pregnancy Complications - epidemiology Pregnancy Complications - metabolism Prevalence Risk Rural Health serum trace elements Urban Health Young Adult Zinc - analysis Zinc - blood Zinc - deficiency India lead levels neonate post-partum women placental Pb levels serum trace elements
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Aim To determine lead (Pb) and trace element (Fe, Zn, Cu, Mg) levels in placenta, maternal and cord blood; further, to assess the interactions between Pb and trace elements, if any. Methods A cluster of ‘at term pregnant women’ from rural and urban areas (n = 30 each, total n = 60) as well as their neonates after delivery were recruited. Maternal blood, heel prick neonatal blood, placenta and cord blood were collected at the time of parturition. Pb and trace element levels in blood/serum, placenta were determined on graphite furnace atomic absorption (AAS) and flame AAS respectively. Due to sample constraints, only Pb levels were determined in heel prick blood samples of neonates. Results There were no major abnormal signs and symptoms, however, 38% had pale conjunctiva and 13% had pigmented tongue. The blood lead levels (BLL) were significantly (P < 0.05) higher in urban post‐partum women compared to their rural counterparts. Higher BLL did not correlate with either pregnancy outcome or neonatal anthropometry. Maternal serum trace element levels were deficient in both rural and urban women. Significant (P < 0.01) positive correlation between maternal and neonatal BLL as well as significant (P < 0.05) inverse correlation between cord BLL and placental Pb levels were observed. Maternal and cord BLL correlated inversely (P < 0.05) with maternal and cord serum Fe levels, respectively. Conclusion Urban post‐partum women and their neonates were at higher risk with elevated BLL. Estimate of cord blood Pb may not be the true index of neonatal BLL. These observations must be confirmed in a larger cohort because prenatal/neonatal screening avoids the risks associated with rest of life.
Bibliography:	Indian Council of Medical Research (ICMR) ark:/67375/WNG-CR7KMZS7-C ArticleID:JOG12469 istex:9A7FA5AEA2218980DEA3C20ACEA01DB9A95D0986 Senior Research Fellowship ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1341-8076 1447-0756
DOI:	10.1111/jog.12469