Search Results - "Ramakrishnan, Saravanan"

Defining super-enhancer landscape in triple-negative breast cancer by multiomic profiling by Huang, Hao, Hu, Jianyang, Maryam, Alishba, Huang, Qinghua, Zhang, Yuchen, Ramakrishnan, Saravanan, Li, Jingyu, Ma, Haiying, Ma, Victor W. S., Cheuk, Wah, So, Grace Y. K., Wang, Wei, Cho, William C. S., Zhang, Liang, Chan, Kui Ming, Wang, Xin, Chin, Y. Rebecca

“…Breast cancer is a heterogeneous disease, affecting over 3.5 million women worldwide, yet the functional role of cis-regulatory elements including…”
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Immunogenicity and protective efficacy of an inactivated Newcastle disease virus vaccine encapsulated in poly-(lactic-co-glycolic acid) nanoparticles by Ananda Kumar, B.S., Panickan, Sivasankar, Bindu, Suresh, Kumar, Vimal, Ramakrishnan, Saravanan, Saxena, Sonal, Shrivastava, Sameer, Dandapat, Satyabrata

“…An immunization experiment was conducted in specific pathogen-free chickens with the inactivated Newcastle disease virus (NDV) vaccine encapsulated in the…”
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TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis by Hu, Jianyang, Lai, Yuni, Huang, Hao, Ramakrishnan, Saravanan, Pan, Yilin, Ma, Victor W. S., Cheuk, Wah, So, Grace Y. K., He, Qingling, Geoffrey Lau, C., Zhang, Liang, Cho, William C. S., Chan, Kui Ming, Wang, Xin, Rebecca Chin, Y.

“…Background Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. By performing multiomic profiling, we recently…”
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Counteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription by Ramakrishnan, Saravanan, Pokhrel, Srijana, Palani, Sowmiya, Pflueger, Christian, Parnell, Timothy J., Cairns, Bradley R., Bhaskara, Srividya, Chandrasekharan, Mahesh B.

“…Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic roles in transcription and chromatin dynamics remain…”
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Combination of TLR2 and TLR3 agonists derepress infectious bursal disease virus vaccine-induced immunosuppression in the chicken by Bashir, Khalid, Kappala, Deepthi, Singh, Yogendra, Dar, Javeed Ahmad, Mariappan, Asok Kumar, Kumar, Ajay, Krishnaswamy, Narayanan, Dey, Sohini, Chellappa, Madhan Mohan, Goswami, Tapas Kumar, Gupta, Vivek Kumar, Ramakrishnan, Saravanan

“…Live intermediate plus infectious bursal disease virus (IBDV) vaccines (hot vaccines) are used for protection against the virulent IBDV strains in young…”
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Newcastle Disease Virus Vectored Chicken Infectious Anaemia Vaccine Induces Robust Immune Response in Chickens by Chellappa, Madhan Mohan, Dey, Sohini, Pathak, Dinesh Chandra, Singh, Asmita, Ramamurthy, Narayan, Ramakrishnan, Saravanan, Mariappan, Asok Kumar, Dhama, Kuldeep, Vakharia, Vikram N

“…Newcastle disease virus (NDV) strain R2B, with an altered fusion protein cleavage site, was used as a viral vector to deliver the immunogenic genes VP2 and VP1…”
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Evaluation of a Lipopolysaccharide and Resiquimod Combination as an Adjuvant with Inactivated Newcastle Disease Virus Vaccine in Chickens by Sharma, Bal Krishan, Ramakrishnan, Saravanan, Kaliappan, Abinaya, Singh, Mithilesh, Kumar, Ajay, Dandapat, Satyabrata, Dey, Sohini, Chellappa, Madhan Mohan

“…Various toll-like receptor (TLR) agonists have shown potential as adjuvants with different vaccines in both human and livestock species, including chickens…”
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Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens by Saikia, Deep Prakash, Yadav, Kalpana, Pathak, Dinesh C, Ramamurthy, Narayan, D'Silva, Ajai Lawrence, Marriappan, Asok Kumar, Ramakrishnan, Saravanan, Vakharia, Vikram N, Chellappa, Madhan Mohan, Dey, Sohini

“…Newcastle disease (ND) and avian reovirus (ARV) infections are a serious threat to the poultry industry, which causes heavy economic losses. The mesogenic NDV…”
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Administration of TLR7 agonist, resiquimod, in different types of chicken induces a mixed Th1 and Th2 response in the peripheral blood mononuclear cells by Annamalai, Arunsaravanakumar, Ramakrishnan, Saravanan, Sachan, Swati, Sharma, Bal Krishan, Anand Kumar, B.S., Kumar, Vimal, Badasara, Surendra Kumar, Kumar, Ajay, Saravanan, B.C., Krishnaswamy, Narayanan

“…•We demonstrated resiquimod (R848) induced immune response in three chicken breeds.•Expression of IFN-γ, IL-1β and TLR7 was high in Kadaknath birds.•Expression…”
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Newcastle Disease Virus Vectored Bivalent Vaccine against Virulent Infectious Bursal Disease and Newcastle Disease of Chickens by Dey, Sohini, Chellappa, Madhan Mohan, Pathak, Dinesh C, Gaikwad, Satish, Yadav, Kalpana, Ramakrishnan, Saravanan, Vakharia, Vikram N

“…Newcastle disease virus (NDV) strain F is a lentogenic vaccine strain used for primary vaccination in day-old chickens against Newcastle disease (ND) in India…”
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Polymorphism in the leucine-rich repeats of TLR7 in different breeds of chicken and in silico analysis of its effect on TLR7 structure and function by Kaliappan, Abinaya, Ramakrishnan, Saravanan, Thomas, Prasad, Verma, Surya Kant, Panwar, Khushboo, Singh, Mithilesh, Dey, Sohini, Mohan Chellappa, Madhan

“…•We compared the SNPs associated with the ligand binding site of chTLR7 in three indigenous and one exotic chicken breeds.•Four synonymous SNPs (P123P, I171I,…”
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Structure–Activity Relationships toward the Identification of a High-Potency Selective Human Toll-like Receptor‑7 Agonist by Kaushik, Deepender, Kaur, Arshpreet, Patil, Madhuri T., Sihag, Binita, Piplani, Sakshi, Sakala, Isaac, Honda-Okubo, Yoshikazu, Ramakrishnan, Saravanan, Petrovsky, Nikolai, Salunke, Deepak B.

“…Toll-like receptor (TLR)-7 agonists are immunostimulatory vaccine adjuvants. A systematic structure–activity relationship (SAR) study of TLR7-active…”
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The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer by Kang, Tze Zhen Evangeline, Zhu, Lina, Yang, Du, Ding, Dongbo, Zhu, Xiaoxuan, Wan, Yi Ching Esther, Liu, Jiaxian, Ramakrishnan, Saravanan, Chan, Landon Long, Chan, Siu Yuen, Wang, Xin, Gan, Haiyun, Han, Junhong, Ishibashi, Toyotaka, Li, Qing, Chan, Kui Ming

“…The recent discovery of the cancer-associated E76K mutation in histone H2B (H2BE76-to-K) in several types of cancers revealed a new class of oncohistone…”
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Resiquimod enhances mucosal and systemic immunity against avian infectious bronchitis virus vaccine in the chicken by Matoo, Javaid Jeelani, Bashir, Khalid, Kumar, Ajay, Krishnaswamy, Narayanan, Dey, Sohini, Chellappa, Madhan Mohan, Ramakrishnan, Saravanan

“…Adjuvant enhancing mucosal immune response is preferred in controlling many pathogens at the portal of entry. Earlier, we reported that a toll-like-receptor 7…”
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Dietary selenium levels modulates antioxidant, cytokine and immune response and selenoproteins mRNA expression in rats under heat stress condition by Aderao, Ganesh Narayanrao, Jadhav, Sunil Ekanath, Pattanaik, Ashok Kumar, Gupta, Sanjay Kumar, Ramakrishnan, Saravanan, Lokesha, E., Chaudhary, Pramod, Vaswani, Shalini, Singh, Asmita, Panigrahi, Manjit, Dutta, Narayan, Singh, Gyanendra

“…Higher environmental temperature is a major abiotic stress factor for animals and human beings. The selenium (Se) is an important trace mineral having diverse…”
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FOSL1 is a key regulator of a super-enhancer driving TCOF1 expression in triple-negative breast cancer by He, Qingling, Hu, Jianyang, Huang, Hao, Wu, Tan, Li, Wenxiu, Ramakrishnan, Saravanan, Pan, Yilin, Chan, Kui Ming, Zhang, Liang, Yang, Mengsu, Wang, Xin, Chin, Y. Rebecca

“…Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with an unmet clinical need, but its epigenetic regulation remains largely…”
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Active immunization with Brucella abortus S19 phage lysate elicits serum IgG that protects guinea pigs against virulent B. abortus and protects mice by passive immunization by Jain, Lata, Rawat, Mayank, Ramakrishnan, Saravanan, Kumar, Bablu

“…Brucellosis is an economically important zoonosis of worldwide significance. Earlier (Jain et al., 2015) we reported methodology for generation of phage lysate…”
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Histone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns by Bai, Jinyue, Jiang, Peiyong, Ji, Lu, Lam, W K Jacky, Zhou, Qing, Ma, Mary-Jane L, Ding, Spencer C, Ramakrishnan, Saravanan, Wan, Chun Wai, Yang, Tongxin Claire, Yukawa, Masashi, Chan, Rebecca W Y, Qiao, Rong, Yu, Stephanie C Y, Choy, L Y Lois, Shi, Yuwei, Wang, Zilong, Tam, Tommy H C, Law, Man Fai, Wong, Raymond S M, Wong, John, Chan, Stephen Lam, Wong, Grace L H, Wong, Vincent W S, Chan, K C Allen, Lo, Y M Dennis

“…The analysis of tissues of origin of cell-free DNA (cfDNA) is of research and diagnostic interest. Many studies focused on bisulfite treatment or…”
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First description of natural concomitant infection of avian nephritis virus and infectious bronchitis virus reveals exacerbated inflammatory response and renal damage in broiler chicks by Munuswamy, Palanivelu, Ramakrishnan, Saravanan, Latheef, Shyma K., Kappala, Deepthi, Mariappan, Asok Kumar, Kaore, Megha, Anbazhagan, Karthikeyan, Puvvala, Bhavani, Singh, Karam Pal, Dhama, Kuldeep

“…We describe the first report on spontaneous Avian Nephritis Virus (ANV) and Infectious Bronchitis Virus (IBV) concurrent infection in broiler chicks. On…”
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Synergy of lipopolysaccharide and resiquimod on type I interferon, pro-inflammatory cytokine, Th1 and Th2 response in chicken peripheral blood mononuclear cells by Ramakrishnan, Saravanan, Annamalai, Arunsaravanakumar, Sachan, Swati, Kumar, Anand, Sharma, Bal Krishan, Govindaraj, Elaiyaraja, Chellappa, Madhan Mohan, Dey, Sohini, Krishnaswamy, Narayanan

“…•Lipopolysaccharide and resiquimod induced a synergistic response in chicken PBMCs.•LPS and R-848 synergistically up-regulated Th1 (IFN-γ) and Th2 (IL-4)…”
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