Search Results - "Ramakrishnan, Krithika"
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Optimising CNT-FET biosensor design through modelling of biomolecular electrostatic gating and its application to β-lactamase detection
Published in Nature communications (29-08-2024)“…Carbon nanotube field effect transistors (CNT-FET) hold great promise as next generation miniaturised biosensors. One bottleneck is modelling how proteins,…”
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Functional Characterization of Novel Sesquiterpene Synthases from Indian Sandalwood, Santalum album
Published in Scientific reports (15-05-2015)“…Indian Sandalwood, Santalum album L. is highly valued for its fragrant heartwood oil and is dominated by a blend of sesquiterpenes. Sesquiterpenes are formed…”
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Characterization of 10-Hydroxygeraniol Dehydrogenase from Catharanthus roseus Reveals Cascaded Enzymatic Activity in Iridoid Biosynthesis
Published in Scientific reports (05-02-2015)“…Catharanthus roseus [L.] is a major source of the monoterpene indole alkaloids (MIAs), which are of significant interest due to their therapeutic value. These…”
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Differential Bio‐Optoelectronic Gating of Semiconducting Carbon Nanotubes by Varying the Covalent Attachment Residue of a Green Fluorescent Protein
Published in Advanced functional materials (01-05-2022)“…Integrating photoactive proteins with synthetic nanomaterials holds great promise in developing optoelectronic devices whereby light, captured by a antenna…”
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Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2
Published in Biochemical journal (31-01-2023)“…Pseudokinases, so named because they lack one or more conserved canonical amino acids that define their catalytically active relatives, have evolved a variety…”
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Glycosylation increases active site rigidity leading to improved enzyme stability and turnover
Published in The FEBS journal (01-08-2023)“…Glycosylation is the most prevalent protein post‐translational modification, with a quarter of glycosylated proteins having enzymatic properties. Yet, the full…”
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Structural studies on 10‐hydroxygeraniol dehydrogenase: A novel linear substrate‐specific dehydrogenase from Catharanthus roseus
Published in Proteins, structure, function, and bioinformatics (01-09-2020)“…Conversion of 10‐hydroxygeraniol to 10‐oxogeranial is a crucial step in iridoid biosynthesis. This reaction is catalyzed by a zinc‐dependent alcohol…”
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New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
Published in Biochemical journal (14-08-2018)“…Protein tyrosine sulfation is a post-translational modification best known for regulating extracellular protein-protein interactions. Tyrosine sulfation is…”
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New tools for carbohydrate sulfation analysis: heparan sulfate 2- O -sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors
Published in Biochemical journal (14-08-2018)“…Sulfation of carbohydrate residues occurs on a variety of glycans destined for secretion, and this modification is essential for efficient matrix-based signal…”
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Transformation of (±)-lavandulol and (±)-tetrahydrolavandulol by a fungal strain Rhizopus oryzae
Published in Bioresource technology (01-07-2012)“…► Biotransformation of lavandulol and tetrahydrolavandulol studied using Rhizopus oryzae. ► Five metabolites isolated and characterized with lavandulol. ► Two…”
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xGen-VideoSyn-1: High-fidelity Text-to-Video Synthesis with Compressed Representations
Published 22-08-2024“…We present xGen-VideoSyn-1, a text-to-video (T2V) generation model capable of producing realistic scenes from textual descriptions. Building on recent…”
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