Search Results - "Ramakrishnan, Ashwin"

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia by Cole, Alicia, Wang, Zezhou, Coyaud, Etienne, Voisin, Veronique, Gronda, Marcela, Jitkova, Yulia, Mattson, Rachel, Hurren, Rose, Babovic, Sonja, Maclean, Neil, Restall, Ian, Wang, Xiaoming, Jeyaraju, Danny V., Sukhai, Mahadeo A., Prabha, Swayam, Bashir, Shaheena, Ramakrishnan, Ashwin, Leung, Elisa, Qia, Yi Hua, Zhang, Nianxian, Combes, Kevin R., Ketela, Troy, Lin, Fengshu, Houry, Walid A., Aman, Ahmed, Al-awar, Rima, Zheng, Wei, Wienholds, Erno, Xu, Chang Jiang, Dick, John, Wang, Jean C.Y., Moffat, Jason, Minden, Mark D., Eaves, Connie J., Bader, Gary D., Hao, Zhenyue, Kornblau, Steven M., Raught, Brian, Schimmer, Aaron D.

“…From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of…”
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tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish by Ignatius, Myron S, Hayes, Madeline N, Moore, Finola E, Tang, Qin, Garcia, Sara P, Blackburn, Patrick R, Baxi, Kunal, Wang, Long, Jin, Alexander, Ramakrishnan, Ashwin, Reeder, Sophia, Chen, Yidong, Nielsen, Gunnlaugur Petur, Chen, Eleanor Y, Hasserjian, Robert P, Tirode, Franck, Ekker, Stephen C, Langenau, David M

“…The tumor-suppressor gene is mutated in >50% of human tumors and Li-Fraumeni patients with germ line inactivation are predisposed to developing cancer. Here,…”
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Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma by Tenente, Inês M, Hayes, Madeline N, Ignatius, Myron S, McCarthy, Karin, Yohe, Marielle, Sindiri, Sivasish, Gryder, Berkley, Oliveira, Mariana L, Ramakrishnan, Ashwin, Tang, Qin, Chen, Eleanor Y, Petur Nielsen, G, Khan, Javed, Langenau, David M

“…Rhabdomyosarcoma (RMS) is a pediatric malignacy of muscle with myogenic regulatory transcription factors MYOD and MYF5 being expressed in this disease…”
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Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc-null SCID zebrafish by Moore, John C, Tang, Qin, Yordán, Nora Torres, Moore, Finola E, Garcia, Elaine G, Lobbardi, Riadh, Ramakrishnan, Ashwin, Marvin, Dieuwke L, Anselmo, Anthony, Sadreyev, Ruslan I, Langenau, David M

“…Cell transplantation into immunodeficient mice has revolutionized our understanding of regeneration, stem cell self-renewal, and cancer; yet models for direct…”
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Identification and characterization of second-generation EZH2 inhibitors with extended residence times and improved biological activity by Stuckey, Jacob I., Cantone, Nico R., Côté, Alexandre, Arora, Shilpi, Vivat, Valerie, Ramakrishnan, Ashwin, Mertz, Jennifer A., Khanna, Avinash, Brenneman, Jehrod, Gehling, Victor S., Moine, Ludivine, Sims, Robert J., Audia, James E., Trojer, Patrick, Levell, Julian R., Cummings, Richard T.

“…The histone methyltransferase EZH2 has been the target of numerous small-molecule inhibitor discovery efforts over the last 10+ years. Emerging clinical data…”
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Design, Synthesis, and Pharmacological Evaluation of Second Generation EZH2 Inhibitors with Long Residence Time by Khanna, Avinash, Côté, Alexandre, Arora, Shilpi, Moine, Ludivine, Gehling, Victor S., Brenneman, Jehrod, Cantone, Nico, Stuckey, Jacob I., Apte, Shruti, Ramakrishnan, Ashwin, Bruderek, Kamil, Bradley, William D., Audia, James E., Cummings, Richard T., Sims, Robert J., Trojer, Patrick, Levell, Julian R.

“…Histone methyltransferase EZH2, which is the catalytic subunit of the PRC2 complex, catalyzes the methylation of histone H3K27—a transcriptionally repressive…”
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Magnetic Hammer Actuation for Tissue Penetration Using a Millirobot by Leclerc, Julien, Ramakrishnan, Ashwin, Tsekos, Nikolaos V., Becker, Aaron T.

“…Untethered magnetic navigation of millirobots within a human body using a magnetic resonance imaging (MRI) scanner is a promising technology for minimally…”
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Abstract A87: Targeting the mitochondrial quality control machinery in acute myeloid leukemia by Jeyaraju, Danny V., Voisin, Veronique, Ramakrishnan, Ashwin, Hurren, Rose, Maclean, Neil, Gronda, Marcela, Minden, Mark, Bader, Gary, Schimmer, Aaron D.

“…Recently, we demonstrated that a subset of AML cells and stem cells have metabolic vulnerabilities in the mitochondria and oxidative phosphorylation (OXPHOS)…”
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Abstract 4177: Dynamic visualization of cancer cell engraftment into immune compromised zebrafish by Moore, John C., Tang, Qin, Torres Yordan, Nora, Mulligan, Timothy, Moore, Finola E., Lobbardi, Riadh, Ramakrishnan, Ashwin, Anselmo, Anthony, Sadreyev, Ruslan, Berman, Jason, Liwski, Robert, Weinstein, Brant, Rawls, John, Langenau, David M.

“…Cell transplantation into immune compromised mice has transformed our understanding of cancer and is now the gold standard for assessing therapeutic responses…”
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Targeting the Mitochondrial Processing Peptidase as a therapeutic strategy for Acute Myeloid Leukemia by Ramakrishnan, Ashwin

“…Acute myeloid leukemia (AML) is a highly heterogeneous disease characterized by a wide variety of cytogenetic abnormalities. Treatment has been largely…”
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Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leuekmia by Cole, Alicia, Wang, Zezhou, Coyaud, Etienne, Voisin, Veronique, Gronda, Marcela, Jitkova, Yulia, Mattson, Rachel, Hurren, Rose, Babovic, Sonja, Maclean, Neil, Restall, Ian, Wang, Xiaoming, Jeyaraju, Danny V., Sukhai, Mahadeo A., Prabha, Swayam, Bashir, Shaheena, Ramakrishnan, Ashwin, Leung, Elisa, Qia, Yi Hua, Zhang, Nianxian, Combes, Kevin R., Ketela, Troy, Lin, Fengshu, Houry, Walid A., Aman, Ahmed, Al-awar, Rima, Zheng, Wei, Wienholds, Erno, Xu, Chang Jiang, Dick, John, Wang, Jean C.Y., Moffat, Jason, Minden, Mark D., Eaves, Connie J., Bader, Gary D., Hao, Zhenyue, Kornblau, Steven M., Raught, Brian, Schimmer, Aaron D.

“…From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of…”
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A novel implementation of sequential output based parallel processing - orthogonal wavelet division multiplexing for DAS on SDR platform by Mahapatra, C., Ramakrishnan, A., Stouraitis, T., Leung, V. C. M.

“…The distributed antenna system (DAS) concept promises to enhance the capacity and diversity of next-generation wireless communication networks, due to the…”
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