Clinical and EEG features of acute intrathecal baclofen overdose

[...]we estimated that the patient received 55mg baclofen intrathecally. The hypothesis is that blocking the presynaptic release of neurotransmitters would lead to a suppression of inhibition, through an effect on inhibitory interneurons, resulting in cellular polarization responsible for seizures [...

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Bibliographic Details
Published in:	Clinical neurology and neurosurgery Vol. 114; no. 1; pp. 84 - 86
Main Authors:	Sauneuf, Bertrand, Totouom, Hervé Kamga, Savary, Benoit, Varin, Laurent, Dupeyrat, Julien, Ramakers, Sophie, Hanouz, Jean-Luc
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01-01-2012 Elsevier Elsevier Limited
Subjects:	Acute respiratory failure Baclofen Baclofen - administration & dosage Baclofen - adverse effects Baclofen - cerebrospinal fluid Biological and medical sciences Drug Overdose Drug therapy Electroencephalography Electroencephalography - drug effects Ependymoma - surgery Equipment Failure GABA Agonists - administration & dosage GABA Agonists - adverse effects GABA Agonists - cerebrospinal fluid Glasgow Coma Scale Humans Implantable pump Infusion Pumps, Implantable Injections, Spinal Intensive care Intrathecal overdose Male Medical sciences Middle Aged Muscle Relaxants, Central - administration & dosage Muscle Relaxants, Central - adverse effects Muscle Relaxants, Central - cerebrospinal fluid Neurology Neurosurgery Quadriplegia - etiology Respiratory Distress Syndrome, Adult - etiology Spinal Neoplasms - surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Acute respiratory failure Intrathecal overdose Implantable pump Baclofen Nervous system diseases Surgery Overdosing Electroencephalography Acute respiratory insufficiency Intrathecal
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Summary:	[...]we estimated that the patient received 55mg baclofen intrathecally. The hypothesis is that blocking the presynaptic release of neurotransmitters would lead to a suppression of inhibition, through an effect on inhibitory interneurons, resulting in cellular polarization responsible for seizures [10]. [...]while baclofen may have antiepileptic properties at low doses, high doses lead to a net excitatory effect.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0303-8467 1872-6968
DOI:	10.1016/j.clineuro.2011.07.028