Search Results - "Ramakers, Ger"

Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits by Ramakers, Ger J.A., Wolfer, David, Rosenberger, Georg, Kuchenbecker, Kerstin, Kreienkamp, Hans-Jürgen, Prange-Kiel, Janine, Rune, Gabriele, Richter, Karin, Langnaese, Kristina, Masneuf, Sophie, Bösl, Michael R., Fischer, Klaus-Dieter, Krugers, Harm J., Lipp, Hans-Peter, van Galen, Elly, Kutsche, Kerstin

“…Mutations in the ARHGEF6 gene, encoding the guanine nucleotide exchange factor αPIX/Cool-2 for the Rho GTPases Rac1 and Cdc42, cause X-linked intellectual…”
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Improved Long-Term Potentiation and Memory in Young Tau-P301L Transgenic Mice before Onset of Hyperphosphorylation and Tauopathy by Boekhoorn, Karin, Terwel, Dick, Biemans, Barbara, Borghgraef, Peter, Wiegert, Olof, Ramakers, Ger J. A, de Vos, Koos, Krugers, Harm, Tomiyama, Takami, Mori, Hiroshi, Joels, Marian, van Leuven, Fred, Lucassen, Paul J

“…The microtubule binding protein tau is implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) with Parkinsonism caused by diverse…”
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NETMORPH: A Framework for the Stochastic Generation of Large Scale Neuronal Networks With Realistic Neuron Morphologies by Koene, Randal A., Tijms, Betty, van Hees, Peter, Postma, Frank, de Ridder, Alexander, Ramakers, Ger J. A., van Pelt, Jaap, van Ooyen, Arjen

“…We present a simulation framework, called NETMORPH, for the developmental generation of 3D large-scale neuronal networks with realistic neuron morphologies. In…”
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Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice by Sennvik, Kristina, Boekhoorn, Karin, Lasrado, Reena, Terwel, Dick, Verhaeghe, Steven, Korr, Hubert, Schmitz, Christoph, Tomiyama, Takami, Mori, Hiroshi, Krugers, Harm, Joels, Marian, Ramakers, Ger J.A, Lucassen, Paul J, Van Leuven, Fred

“…Differential isoform expression and phosphorylation of protein tau are believed to regulate the assembly and stabilization of microtubuli in fetal and adult…”
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Rho proteins, mental retardation and the cellular basis of cognition by Ramakers, Ger J.A.

“…For several decades, it has been known that mental retardation (MR) is associated with abnormalities in dendrites and dendritic spines. The recent cloning of…”
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Dynamics and plasticity in developing neuronal networks in vitro by van Pelt, Jaap, Vajda, Ildiko, Wolters, Pieter S, Corner, Michael A, Ramakers, Ger J A

“…When dissociated cortical tissue is brought into culture, neurons readily grow out by forming axonal and dendritic arborizations and synaptic connections…”
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Loss of X-Linked Mental Retardation Gene Oligophrenin1 in Mice Impairs Spatial Memory and Leads to Ventricular Enlargement and Dendritic Spine Immaturity by Khelfaoui, Malik, Denis, Cecile, van Galen, Elly, de Bock, Frederic, Schmitt, Alain, Houbron, Christophe, Morice, Elise, Giros, Bruno, Ramakers, Ger, Fagni, Laurent, Chelly, Jamel, Nosten-Bertrand, Marika, Billuart, Pierre

“…Loss of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar hypoplasia and, in some cases, with lateral…”
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Long-term characterization of firing dynamics of spontaneous bursts in cultured neural networks by van Pelt, J., Wolters, P.S., Corner, M.A., Rutten, W.L.C., Ramakers, G.J.A.

“…Extracellular action potentials were recorded from developing dissociated rat neocortical networks continuously for up to 49 days in vitro using planar…”
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Rho proteins, mental retardation and the neurobiological basis of intelligence by van Galen, Elly J M, Ramakers, Ger J A

“…For several decades it has been known that mental retardation is associated with abnormalities in dendrites and dendritic spines. The recent cloning of eight…”
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Neuronal network formation in human cerebral cortex by Ramakers, Ger J A

“…Knowledge of the development of structural and functional connectivity in the human brain is of great fundamental and practical importance, but is largely…”
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Relationships between Visual-Motor and Cognitive Abilities in Intellectual Disabilities by Blasi, Francesco D. Di, Elia, Flaviana, Buono, Serafino, Ramakers, Ger J. A., Nuovo, Santo F. Di

“…The neurobiological hypothesis supports the relevance of studying visual-perceptual and visual-motor skills in relation to cognitive abilities in intellectual…”
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Regulation of Astrocyte Morphology by RhoA and Lysophosphatidic Acid by Ramakers, Ger J.A., Moolenaar, Wouter H.

“…Astrocytes in the CNS undergo morphological changes and start to proliferate after breakdown of the blood–brain barrier. In culture, proliferating astrocytes…”
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Influence of dendritic morphology on axonal competition by van Ooyen, Arjen, Willshaw, David J, Ramakers, Ger J.A

“…The development of nerve connections involves competition among axons for survival promoting factors, or neurotrophins, which are released by the axons’ target…”
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Maternal Care and Hippocampal Plasticity: Evidence for Experience-Dependent Structural Plasticity, Altered Synaptic Functioning, and Differential Responsiveness to Glucocorticoids and Stress by Champagne, Danielle L, Bagot, Rosemary C, van Hasselt, Felisa, Ramakers, Ger, Meaney, Michael J, de Kloet, E. Ronald, Joels, Marian, Krugers, Harm

“…Maternal licking and grooming (LG) in infancy influences stress responsiveness and cognitive performance in the offspring. We examined the effects of variation…”
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Competition for tubulin between growing neurites during development by van Ooyen, Arjen, P. Graham, Bruce, J.A. Ramakers, Ger

“…At its tip—called growth cone—a neurite is elongated by the assembly of tubulin into microtubules. We present a model of elongation (extended from Van Veen and…”
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Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome by Balemans, Monique C M, Kasri, Nael Nadif, Kopanitsa, Maksym V, Afinowi, Nurudeen O, Ramakers, Ger, Peters, Theo A, Beynon, Andy J, Janssen, Sanne M, van Summeren, Rik C J, Eeftens, Jorine M, Eikelenboom, Nathalie, Benevento, Marco, Tachibana, Makoto, Shinkai, Yoichi, Kleefstra, Tjitske, van Bokhoven, Hans, Van der Zee, Catharina E E M

“…Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that catalyzes mono- and dimethylation of histone H3 lysine 9, thereby…”
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Dual compartment neurofluidic system for electrophysiological measurements in physically isolated neuronal cell cultures by Kanagasabapathi, T.T., Ke Wang, Mellace, M., Ramakers, G.J.A., Decre, M.M.J.

“…This work investigates an approach to record electrophysiological measurements of neuronal cell cultures in a dual compartment neurofluidic system. The two…”
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Spontaneous bioelectric activity as both dependent and independent variable in cortical maturation. Chronic tetrodotoxin versus picrotoxin effects on spike-train patterns in developing rat neocortex neurons during long-term culture by Corner, M A, Ramakers, G J

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Dysregulation of Rho GTPases in the [alpha]Pix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits by Ramakers, Ger JA, Wolfer, David, Rosenberger, Georg, Kuchenbecker, Kerstin, Kreienkamp, Hans-Juergen, Prange-Kiel, Janine, Rune, Gabriele, Richter, Karin, Langnaese, Kristina, Masneuf, Sophie, Bosl, Michael R, Fischer, Klaus-Dieter, Krugers, Harm J, Lipp, Hans-Peter, van Galen, Elly, Kutsche, Kerstin

“…Mutations in the ARHGEF6 gene, encoding the guanine nucleotide exchange factor alpha PIX/Cool-2 for the Rho GTPases Rac1 and Cdc42, cause X-linked intellectual…”
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A shape analysis framework for neuromorphometry by Costa, Luciano da Fontoura, Manoel, Edson Tadeu Monteiro, Faucereau, Fabien, Chelly, Jamel, van Pelt, Jaap, Ramakers, Ger

“…This paper addresses in an integrated and systematic fashion the relatively overlooked but increasingly important issue of measuring and characterizing the…”
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