Search Results - "Ramakers, Bart P."

Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia by Pillay, Janesh, Ramakers, Bart P., Kamp, Vera M., Loi, Adele Lo Tam, Lam, Siu W., Hietbrink, Falco, Leenen, Luke P., Tool, Anton T., Pickkers, Peter, Koenderman, Leo

“…Systemic inflammation results in release of refractory neutrophils which can cause susceptibility to infections and activates differentiated neutrophils, which…”
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Inflammation-Induced Increases in Plasma Endocan Levels are Associated With Endothelial Dysfunction in Humans in vivo by Cox, Laura AE, van Eijk, Lucas T, Ramakers, Bart PC, Dorresteijn, Mirrin J, Gerretsen, Jelle, Kox, Matthijs, Pickkers, Peter

“…ABSTRACTAlthough endothelial dysfunction is central to the pathogenesis of sepsis, no specific and clinically applicable marker for endothelial dysfunction is…”
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Caffeine Prevents Protection in Two Human Models of Ischemic Preconditioning by Riksen, Niels P., Zhou, Zhigang, Oyen, Wim J.G., Jaspers, Rogier, Ramakers, Bart P., Brouwer, Rene M.H.J., Boerman, Otto C., Steinmetz, Neil, Smits, Paul, Rongen, Gerard A.

“…Caffeine Prevents Protection in 2 Human Models of Ischemic Preconditioning Niels P. Riksen, Zhigang Zhou, Wim J. G. Oyen, Rogier Jaspers, Bart P. Ramakers,…”
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Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia by Kox, Matthijs, de Kleijn, Stan, Pompe, Jan C, Ramakers, Bart P, Netea, Mihai G, van der Hoeven, Johannes G, Hoedemaekers, Cornelia W, Pickkers, Peter

“…OBJECTIVES:Endotoxin (lipopolysaccharide) tolerance is characterized by a transient refractory state to a subsequent lipopolysaccharide challenge. Following…”
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Continuous Administration of Enteral Lipid- and Protein-Rich Nutrition Limits Inflammation in a Human Endotoxemia Model by Lubbers, Tim, Kox, Matthijs, de Haan, Jacco-Juri, Greve, Jan Willem, Pompe, Jan C, Ramakers, Bart P, Pickkers, Peter, Buurman, Wim A

“…OBJECTIVE:An overzealous inflammatory response is an important cause of morbidity and mortality in surgical, trauma, and critically ill patients. Enteral…”
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Zoonotic Chlamydia caviae Presenting as Community-Acquired Pneumonia by Ramakers, Bart P, Heijne, Marloes, Lie, Natascha, Le, Thuy-Nga, van Vliet, Monique, Claessen, Vivian P.J, Tolsma, Paulien J.P, De Rosa, Mauro, Roest, Hendrik I.J, Vanrompay, Daisy, Heddema, Edou R, Schneeberger, Peter, Hermans, Mirjam H.A

“…The gram-negative intracellular bacteria C. caviae was identified as the likely cause of severe community-acquired pneumonia in three patients. Guinea pigs…”
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Modulation of innate immunity by adenosine receptor stimulation by Ramakers, Bart P, Riksen, Niels P, van der Hoeven, Johannes G, Smits, Paul, Pickkers, Peter

“…In the past decades, increased concentrations of the signaling molecule adenosine have been shown to play an important role in the prevention of tissue damage…”
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How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo by Ramakers, Bart P, Wever, Kimberley E, Kox, Matthijs, van den Broek, Petra H, Mbuyi, Faustin, Rongen, Gerard, Masereeuw, Rosalinde, van der Hoeven, Johannes G, Smits, Paul, Riksen, Niels P, Pickkers, Peter

“…OBJECTIVE:Adenosine modulates inflammation and prevents associated organ injury by activation of its receptors. During sepsis, the extracellular adenosine…”
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Endotoxemia-induced inflammation and the effect on the human brain by van den Boogaard, Mark, Ramakers, Bart P, van Alfen, Nens, van der Werf, Sieberen P, Fick, Wilhelmina F, Hoedemaekers, Cornelia W, Verbeek, Marcel M, Schoonhoven, Lisette, van der Hoeven, Johannes G, Pickkers, Peter

“…Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness…”
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Interplay between the acute inflammatory response and heart rate variability in healthy human volunteers by Kox, Matthijs, Ramakers, Bart P, Pompe, Jan C, van der Hoeven, Johannes G, Hoedemaekers, Cornelia W, Pickkers, Peter

“…The autonomic nervous system and the inflammatory response are intimately linked. Heart rate variability (HRV) analysis is a widely used method to assess…”
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Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock by Ferwerda, Bart, Alonso, Santos, Banahan, Kathy, McCall, Matthew B.B, Giamarellos-Bourboulis, Evangelos J, Ramakers, Bart P, Mouktaroudi, Maria, Fain, Pamela R, Izagirre, Neskuts, Syafruddin, Din, Cristea, Tudor, Mockenhaupt, Frank P, Troye-Blomberg, Marita, Kumpf, Oliver, Maiga, Boubacar, Dolo, Amagana, Doumbo, Ogobara, Sundaresan, Santhosh, Bedu-Addo, George, van Crevel, Reinout, Hamann, Lutz, Oh, Djin-Ye, Schumann, Ralf R, Joosten, Leo A.B, de la Rúa, Concepcion, Sauerwein, Robert, Drenth, Joost P.H, Kullberg, Bart-Jan, van der Ven, André J.A.M, Hill, Adrian V, Pickkers, Peter, van der Meer, Jos W.M, O'Neill, Luke A.J, Netea, Mihai G

“…Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic…”
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Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury by Ramakers, Bart P, Riksen, Niels P, van den Broek, Petra, Franke, Barbara, Peters, Wilbert H M, van der Hoeven, Johannes G, Smits, Paul, Pickkers, Peter

“…Preclinical studies have shown that the endogenous nucleoside adenosine prevents excessive tissue injury during systemic inflammation. We aimed to study…”
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Dipyridamole augments the antiinflammatory response during human endotoxemia by Ramakers, Bart P, Riksen, Niels P, Stal, Thijmen H, Heemskerk, Suzanne, van den Broek, Petra, Peters, Wilbert H M, van der Hoeven, Johannes G, Smits, Paul, Pickkers, Peter

“…In animal models of systemic inflammation, the endogenous nucleoside adenosine controls inflammation and prevents organ injury. Dipyridamole blocks the…”
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Adenosine-mediated attenuation of the innate immune response for only those who need it? The tailored potential of pentoxifylline by Ramakers, Bart P, Pickkers, Peter

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Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients by Ramakers, Bart P, Giamarellos-Bourboulis, Evangelos J, Tasioudis, Chronis, Coenen, Marieke J.H, Kox, Matthijs, Vermeulen, Sita H, Groothuismink, Johanne M, van der Hoeven, Johannes G, Routsi, Christina, Savva, Athina, Prekates, Athanassios, Diamantea, Filia, Sinapidis, Dimitrios, Smits, Paul, Toutouzas, Konstantinos, Riksen, Niels P, Pickkers, Peter

“…INTRODUCTION:Adenosine exerts anti-inflammatory and tissue-protective effects during systemic inflammation. While the tissue-protective effects might limit…”
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Deficient Candida-Specific T-Helper 17 Response During Sepsis by van de Veerdonk, Frank L., Mouktaroudi, Maria, Ramakers, Bart P., Pistiki, Aikaterini, Pickkers, Peter, van der Meer, Jos W. M., Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J.

“…Patients with sepsis in the intensive care unit (ICU) are prone to develop Candida infections. Here, we investigated Candida-induced T-helper 17…”
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Inflammation-induced hepatotoxicity in humans by Ramakers, Bart P, de Goeij, Moniek, van der Hoeven, Johannes G, Peters, Wilbert H M, Pickkers, Peter

“…Because severe sepsis is frequently complicated by multiple organ failure, it is of importance to monitor organ function. Unfortunately, conventional liver…”
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Oral therapy with dipyridamole limits ischemia-reperfusion injury in humans by Riksen, Niels P., Oyen, Wim J. G., Ramakers, Bart P., Broek, Petra H. H., Engbersen, Richard, Boerman, Otto C., Smits, Paul, Rongen, Gerard A.

“…Background Adenosine receptor stimulation induces several effects that could limit ischemia‐reperfusion injury. We hypothesize that treatment with the…”
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Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans by RONGEN, Gerard A, OYEN, Wim J. G, RAMAKERS, Bart P, RIKSEN, Niels P, BOERMAN, Otto C, STEINMETZ, Neil, SMITS, Paul

“…Nonlethal ischemia and reperfusion reduce ischemia-reperfusion-induced cell death, a phenomenon called ischemic preconditioning. In animal models, this potent…”
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Body mass index is not associated with cytokine induction during experimental human endotoxemia by van Eijk, Lucas T, van der Pluijm, Rob W, Ramakers, Bart Pc, Dorresteijn, Mirrin J, van der Hoeven, Johannes G, Kox, Matthijs, Pickkers, Peter

“…A higher body mass index (BMI) appears to be associated with lower mortality in critically ill patients, possibly explained by an altered innate immune…”
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